第5例——发烧、咳嗽、进行性消瘦

病历摘要患者男性,49岁,工人,因发烧、咳嗽、进行性消瘦一月余,于1978年7月人院。在一个月前出现咳嗽、发热(37.5～39°),伴有胸痛,咯少量白泡沫痰,夜间不能平卧,纳减,体重下降约10公斤。曾抗感染治疗无效。查痰抗酸杆菌(一)。接触水泥粉尘     

血液系统恶性肿瘤p16基因甲基化研究

多种肿瘤抑制因子１基因（ＭＴＳ１／ｐ１６）是１９９４年Ｋａｍｂ等［１］克隆出的一种新的抑癌基因，其失活以纯合子缺失及甲基化为主，而点突变则极少见。为进一步探讨血液系统恶性肿瘤ｐ１６基因失活的发生率及其与疾病的发生、发展、预后的关系，我们对１９９５～１...     

维生素D3对血管新生抑制作用的研究

骨病是多发性骨髓瘤(MM)的重要临床表现之一，1．25(OH)2D3(VD3)在治疗骨病的同时，还具有抗血管新生的作用。本实验目的是研究VD3，对血管内皮生长因子(VEGF)诱导的人骨髓来源内皮细胞系HBME-1的增殖、迁移、微血管形成的抑制作用，以便了解应用VD3治疗MM新的作用机制。     

A study of immunoglobulin heavy chain gene rearrangement in plasmacyte proliferative disease

ＡｓｔｕｄｙｏｆｉｍｍｕｎｏｇｌｏｂｕｌｉｎｈｅａｖｙｃｈａｉｎｇｅｎｅｒｅａｒｒａｎｇｅｍｅｎｔｉｎｐｌａｓｍａｃｙｔｅｐｒｏｌｉｆｅｒａｔｉｖｅｄｉｓｅａｓｅＣｈｅｎＷｅｎｍｉｎｇ陈文明，ＺｈｕＪｉａｚｈｉ朱嘉芷，ＺｈａｎｇＰｅｎｇ张鹏，ＳｕｎＷ...     

多发性骨髓瘤血管新生的体外研究

探讨多发性骨髓瘤细胞系培养上清液对人骨髓来源内皮细胞系(HBMEC)的增殖、迁移及血管新生的作用。用含2％胎牛血清(FBS)的RPMI 1640培养液培养骨髓瘤细胞系获得上清液,将此培养液培养HBMEC,研究其时HBMEC的增殖及迁移的影响,并将此液放入含有携带HBMEC微珠的三维纤维蛋白中,研究其对血管新生的影响。结果表明,与含2％FBS的RPMI 1640培养液比较,骨髓瘤细胞系培养液对HBMEC的增殖有明显促进作用(P<0.001),并促进HBMEC的迁移,诱导毛细血管管腔的形成(长度及宽度)(P<0.001)。结论:骨髓瘤细胞系可能通过分泌某些细胞因子促进HBMEC增殖、迁移及血管新生。     

CONTROL OF ANGIOGENESIS BY INHIBITOR OF PHOSPHOLIPASE A2

Objective To investigate the potential effects of angiogenic process by secretory phospholipase A2 (sPLA2) inhibitor-HyPE (linking N-derivatized phosphatidyl-ethanolamine to hyaluronie acid) on human bone marrow endothelial cell line (HBME-1). Methods In order to examine the suppressing effects of HyPE on HBME-1 proliferation, migration, and capillary-like tube formation, HBME-1 were activated by angiogenic factor, specifically by basic fibroblast growth factor (b-FGF), vascular endothelial growth factor (VEGF), and oncostatin M (OSM) (at a final concentration of 25, 20, and 2.5ng/mL, respectively), then HBME-1 proliferation, migration, and tube formation were studied in the absence or presence of HyPE. HBME-1 tube formation was specially analyzed in fibrin gel. Results HyPE effectively inhibited HBME-1 proliferation and migration as a dose-dependent manner,whatever HBME-1 were grown in the control culture medium or stimulated with b-FGF, VEGF, or OSM. In fibrin, the formations of HBME-1 derived tube-like structures were enhanced by all angiogenic factors, but these were strongly suppressed by HyPE. Conclusions The results support the involvement of sPLA2 in angiogenesis. It is proposed that sPLA2 inhibitor introduces a novel approach in the control of cancer development.     

世界卫生组织关于血液系统恶性疾病分类的意见

1997年11月世界卫生组织(WHO)召集了临床顾问委员会(CAC)及指导委员会的专家在弗吉尼亚召开了一次会议,着重讨论了国际淋巴瘤研究组(ILSG)在1994年提出的"修改的欧-美淋巴瘤分类(REAL)"[1],并按照该分类方法的原理(将形态学、免疫表型、细胞遗传学及临床表现相结合)对髓系恶性瘤进行了分类[2].现对分类结果作一报道.