益脑冲剂对实验性脑缺血损伤的保护作用

大脑中动脉凝闭所致局灶性脑缺血大鼠出现明显的神经症状、脑组织损伤、脑超微结构明显改变，缺血区脑组织水含量及Ｎａ＋含量明显增加。益脑冲剂对上述指标有明显改善效果。     

心率的Poincare散点图与分维的比较

我们利用动物实验的方法，研究了冠状动脉结扎前后心脏两种非线性方法—Poincare散点图和心率分雏的表现。发现这两种非线性方法对冠脉结扎都有明显反应；对呼吸运动方式的敏感性，Poincare散点图比心率变异性(HRV)好，但分维比Poincare散点图更好。说明单用一种非线性方法不能完全揭示心脏状态。     

咪唑安定在心脏电复律中的应用

心脏电复律是严重心律失常患者常用的安全有效治疗措施。但是操作过程中，患者常会有明显的不适感，如皮肤灼痛、肌肉痉挛、疼痛等，甚至极度恐惧而难以合作。适当给予镇静药物可使患者的耐受性提高，配合良好，并产生遗忘作用，即处于一种无焦虑状态。因此我们采用小剂量咪唑安定作为心脏电复律的术前用药，取得了良好效果，现报告如下。     

在义务兵征兵体检中应用PHI和16PF的研究

目的　探讨 PHI和 1 6PF量表在义务征兵体验中的应用。方法　用 PHI和 1 6PF量表评定参加征兵体检并初检合格的应征青年 5 44人 ,分析应用 PHI和 1 6PF量表的可靠性 ,以量表 T分作评判依据 ,比较以国内常模及组内常模进行选拔的效果。结果　PHI与 1 6PF的相关性较好 ,但在项目上具有一定的重叠 ;以国内常模筛选 PHI的检出率相当低 ,而1 6PF则检出率过高 ,筛选有效率均低 ;应用组内的均数、标准差来计算 T分 ,以此 T分进行筛选效果较好。结论　PHI与1 6PF量表可以应用于征兵体检中 ,用组内常模进行选拔效果更好 ,正式推出尚需修订     

填精补血化瘀方对局灶性脑缺血脑保护作用的研究

观察了填精补血化瘀方对光化学诱导局灶性脑缺血大鼠的脑保护作用。结果表明，该方可明显抑制脑缺血后脑水肿的发生发展，改善血管通透性，提高琥珀酸脱氢酶（ＳＤＨ）活性，减轻脑组织损害，其效果优于尼莫地平。     

异亚丙基莽草酸对大脑中动脉栓塞大鼠脑组织自由基代谢的影响

目的　研究异亚丙基莽草酸 (ISA)对大脑中动脉栓塞模型 (MCAT)大鼠脑组织自由基代谢的影响。方法　采用三氯化铁致大脑中动脉栓塞模型 ,观察ISA对脑组织总超氧化物歧化酶 (T SOD)、Cu Zn SOD、谷胱甘肽过氧化物酶(GSH px)活力及丙二醛 (MDA)含量的影响。 结果　ISA2 0 0 ,10 0mg·kg-1可提高模型大鼠脑组织T SOD活力 ;ISA2 0 0 ,10 0 ,5 0mg·kg-1均可明显增加模型大鼠脑组织Cu Zn SOD和GSH px活力 ;ISA 2 0 0 ,10 0 ,5 0mg·kg-1对模型大鼠脑组织MDA升高有明显的抑制作用。结论　ISA可能通过减轻脑组织自由基损伤保护脑组织缺血性损伤     

精神分裂症病人一般自我效能感与应对方式相关性研究

目的探讨精神分裂症病人一般自我效能感与应对方式的关系，为精神分裂症病人心理健康教育提供依据。方法采用一般自我效能感量表（GSES）和简易应对方式问卷（SCSQ）对81例精神分裂症病人进行测评。结果本组对象中，不同性别、年龄、病程的精神分裂症病人的一般自我效能感、积极应对、消极应对的差异无统计学意义；本组精神分裂症病人一般自我效能感显著低于常模（P〈0．001）；其消极应对显著低于常模（P〈0．05），比常模较少采用消极应对方式；积极应对与常模比较，差异无统计学意义（P〉0．05）；一般自我效能感与积极应对、消极应对存在一定的正相关关系（P〈0．05）。结论精神分裂症病人的一般自我效能感与积极应对、消极应对存在一定的正相关关系，提高病人自我效能，将有助于其采取积极有效的应对方式。     

急性肾功能衰竭的非透析疗法

近年来 ,我科经过不断研究探索 ,摸索出一组对急性肾衰 (ＡＲＦ)行之有效的综合治疗药物 ,并成功地治愈了部分ＡＲＦ病人。一、对象与方法1.研究对象　肌酐 >45 0 μｍｏｌ/Ｌ ,尿量≤ 40 0ｍｌ/ｄ ,Ｂ超检查示双侧肾脏弥漫性增大的 5 9例ＡＲＦ病人 ,根据病因按随机号分为两组 ,心血通组 (河北医科大学生物医学工程生产 ,内含心房肽(ＡＮＰ) >16 0 0ｐｇ/ｍｌ,降钙素基因相关肽 (ＣＧＲＰ) 4 86ｐｇ/ｍｌ,以及三磷酸腺苷、腺苷和多种氨基酸及其代谢中间产物 )和常规治疗组。2　治疗方法及观察指标　常规治疗经补足血容量、应用多巴胺、速尿…     

急性脑出血患者血液中微粒促凝活性的变化

Objective To study the procoagulant activity of microparticles (MP) in patients with acute in-tracerebral hemorrhage (ICH) and to evaluate the correlation between procoagulant activity of MPs and disease out-come. Method From August 2006 through August 2008, 83 consecutive patients with history of hypertension ad-mitted for spontaneous basal ganglia hemorrhage including 54 male and 29 female, aged (60.9±9.7) years ranged from 41 to 79 years, were enrolled into this study. The control group was consisted of 30 age- and sex-matched (P= 0.429; P = 0.415) patients admitted for mild soft tissue injury. Patients with history of head trauma or previ-ous stroke, under the antiplatelet or anticoagulant medication, severe infection, or presence of previous cerebrovas-cttlar disease were excluded. Venous blood sample was kaken within the first 24 hours after disease onset. The MPs procoaulant potential was measured with a prothrombinase assay, and the levels of IL-6,TNF-α, D-dimer (DD)and thrombin-antithrombin Ⅲ complex (TAT) in plasma were measured with enzyme-linked immunosorbent assay. The multivariate analysis was made with forward stepwise logistic regression to determined the predictors of one. month mortality. The plasma levels of MPs were compared between ICH group and control group, between patients with intraventricular hemorrhage (IVH) and those without IVH,and between survivors and non-survivors with the Mann-Whitney U-test. The Spearman' s rank correlation coefficient was used to analyze the correlations between the plasma levels of MPs and ICH volume, Glasgow coma scale (GCS), and plasma levels of IL-6, TNF-α, DD and TAT. A receiver operating characteristic curve (ROC curve) identified the plasma MPs cutoff levels that predicted one-month mortality of patients. Under ROC curve, z statistic analysis was used to compare the area under curves (AUCs) between plasma IMPs and Glasgow coma scale, ICH volumes, and plasma levels of IL-6, TNF-α, DD and TAT for one-month mortality. Results Thirty-six patients (43.4%) died of ICH in a month. The multivariate analyses sorted out the GCS (odds ratio = 0.558, 95%CI:0.367-0.850, P = 0.007), Hematoma volume (odds ratio= 1.061, 95%C1:1.012- 1.113, P = 0.015) and IVH (odds ratio= 5.537, 95%CI:1.035-29.629, P = 0.045) as the independent pcedictors for one-week mortality. The MPs procoagulant activity in the ICH group (6.72±3.26 U/mL) was significantly higher than that in control group (1.84±0.82) U/mL (P = 0.000). The IMPs procoagulant activity in the non-survival group (8.51±3.45) U/mL was significantly higher than that in the survival group (5.35±2.33) U/mL (P = 0.000). The MPs procoagulant activity in the IVH group (7.66±3.39) U/mL was significantly higher than that in the non-lVH group (5.36±2.53) U/mL (P = 0.001). The MPs procoagulant activity was highly associated with GCS scores (r = -0.690, P = 0.000), ICH volumes (r =0.590, P = 0.000), and plasma IL-6 (r = 0.465, P = 0.015), TNF-α (r = 0.464, P = 0.016), DD(r= 0.567, P = 0.001) and TAT(r = 0.469, P = 0.014) in ICH. The ROC curve identified cutoff levels of MPs procoagulant activity to be 7.47 U/mL that predicted one-month mortality of patients with high sensitivity (77.8%) and specificity values (76.6%). Areas under curves (AUCs) of MPs procoagulant activity (AUC =0.825±0.048) were significantly larger than those of plasma IL-6 (AUC = 0.685±0.060, P = 0.042), TNF-α(AUC = 0.681±0.060, P =0.036) and TAT (AUC = 0.644±0.062, P =0.008).The AUCs ofMPs procoag-ulant activity were larger than those of plasma DD (AUC = 0.743±0.056), but this difference was not statistical significance (p = 0.226). Conclusions The procoagulant activity of MPs may contribute to the pathophysiology of ICH. The propcoagulant activity of MPs after spontaneous onset of ICH seems to correlate with clinical outcome in these patients. Its procoagulant activity can be used as an useful clinical marker for evaluating the prognosis of ICH.     

脑栓康对D-半乳糖诱导小鼠脑功能衰退的保护作用

目的：探讨脑栓康(NSK)对D-半乳糖诱导小鼠脑功能衰退的保护作用。方法：ICR小鼠随机分为空白对照组、模型对照组、银杏叶提取物(天保宁片)40mg／kg组、NSK25mg／kg组、NSK50mg／kg组、NSK100mg／kg组。小鼠每日颈背部皮下注射D-半乳糖120mg／kg，采用水迷宫试验，测试小鼠的学习记忆能力，并通过测定模型小鼠的学习记忆能力和脑组织超氧化物歧化酶(SOD)，谷胱甘肽过氧化物酶(GSH-Px)活力、丙二醛(MDA)和脂褐素含量，观察NSK对模型小鼠脑功能衰退的保护作用。结果：NSK25，50，100mg／kg可不同程度地改善模型小鼠的学习能力[3组小鼠平均到达B点时间为(43&;#177;18)，(54&;#177;29)，(59&;#177;61)s；而模型对照组到达B点时间为(63&;#177;26)s,t=2．525～2．731，P&;lt;0．05]和记忆能力[NSK25mg／kg组和模型对照组小鼠平均到达B点时间为(25&;#177;26)，(50&;#177;35)8，t=2．254，P&;lt;0．05]。3个剂量均可以增强模型小鼠脑组织SOD，GSH-Px活力，降低MDA和脂褐紊含量(t=-2．675～2．712，P&;lt;0．05，t=-8．806～15．989，P&;lt;0．01)。结论：抑制脑组织脂质过氧化反应，提高脑组织的抗氧化能力，可能是NSK改善行为学异常，防治老年期痴呆的作用机制之一。