胃下垂病因病机的探讨

笔者通过对胃下垂的病因病机的分析,认为胃下垂的产生主要为胃的通降功能失常,本着六腑以通为顺,胃宜降,降则和的原则,提出了以“通腑降浊、调理气机”之法治疗胃下垂,为临床开辟了新的思路。     

改良固定反式TBA联合前牵矫治AngleIII类前牙反对TMJ影响的比较性研究

目的:应用改良固定反式双阻板矫治器(Twin-blockappliance,TBA)联合前牵治疗15例AngleIII类轻、中度骨性前牙反,进行颞颌关节方面研究,以期从颞颌关节适应性改建来探讨其作用机制。方法:测量分析治疗前后颞下颌关节中位断层片变化情况,并与前牵引组及反式TBA组进行比较。结果:未发现一例患者出现TMD症状。联合组治疗前后线性百分比分别为24.67%和11.62%,N/M值治疗前后分别为1.82和1.07,A值及P值变化均较明显,关节前间隙增大,后间隙减小。联合组及反式TBA组髁突发生明显后下移位,前牵引组变化较小。结论:适当持续性矫治力不会对颞颌关节产生不利影响。联合组全天作用引起颞颌关节适应性改建,前牙反锁结的快速解除并结合将前伸的髁突、下颌诱导后退,有利于恢复和建立后牙正常的ICP,真正实现牙位、肌位、关节位的协调一致,此对于矫治前牙反牙合、防止复发具有重要意义。     

动脉瘤性蛛网膜下腔出血术后慢性脑积水形成原因分析

目的探讨动脉瘤性蛛网膜下腔出血术后产生慢性脑积水的原因,以提高患者术后身体恢复质量。方法选取我院2014-2015年收治的蛛网膜下腔出血40例患者为研究对象。按照Hunt-Hess进行分级,其中Ⅱ级6例,Ⅲ级16例,Ⅳ级15例,Ⅴ级3例。结果慢性脑积水30例患者中,Hunt-HessⅢ级13例,Ⅳ级14例,Ⅴ级3例均出现慢性脑积水症状。可见,较高的Hunt-Hess级别是产生慢性脑积水的高危因素。其中60岁以上患者均SAH术后产生慢性脑积水现象,并伴不同程度的高血压症状。结论产生慢性脑积水的高危因素主要集中于SAH发病后的Hunt-Hess级别、脑室积水、年龄较高或具有高血压史、出血次数1次等。     

Differential immunological phenotypes are exhibited after scald and flame burns

A dysfunctional immune system is known to be part of the pathophysiology after burn trauma. However, reports that support this have used a variety of methods, with numerous variables, to induce thermal injury. We hypothesized that, all other parameters being equal, an injury infliction by a scald would yield different immunological responses than one inflicted by a flame. Here, we demonstrated that both burn methods produced a full-thickness burn, yet there was more of an increase in subdermal temperature, hematocrit, mortality, and serum IL-6 concentrations associated with the scald burn. On postinjury day 1, the scald-burned mice showed diminished lymphocyte numbers, interferon gamma production, and lymphocyte T-bet expression as compared with sham- and flame-burned mice. On postburn day 8, spleens from both sets of thermally injured animals showed an increase in proinflammatory myeloid cells as compared with sham-burned mice. Furthermore, the T-cell numbers, T-bet expression, and phenotype were changed such that interferon gamma production was higher in scald-burned mice than in sham- and flame-burned mice. Altogether, the data show that differential immunological phenotypes were observed depending on the thermal injury method used.     

Ischemia-reperfusion injury is attenuated in VAP-1-deficient mice and by VAP-1 inhibitors

Neutrophils mediate the damage caused by ischemia-reperfusion both at the site of primary injury and in remote organs. Vascular adhesion protein-1 (VAP-1) is an ectoenzyme expressed on endothelial cells and it has been shown to regulate leukocyte extravasation. Here we show for the first time using VAP-1-deficient mice that VAP-1 plays a significant role in the intestinal damage and acute lung injury after ischemia-reperfusion. Separate inhibition of VAP-1 by small molecule enzyme inhibitors and a function-blocking monoclonal antibody in WT mice revealed that the catalytic activity of VAP-1 is responsible for its pro-inflammatory action. The use of transgenic humanized VAP-1 mice also showed that the enzyme inhibitors alleviate both the ischemia-reperfusion injury in the gut and neutrophil accumulation in the lungs. These data thus indicate that VAP-1 regulates the inflammatory response in ischemia-reperfusion injury and suggest that blockade of VAP-1 may have therapeutic value.     

Early Diagnosis of Chemotherapy-induced Cardiomyopathy: a Prospective Tissue Doppler Imaging Study

The aim of our study was to compare the applicability of the conventional echocardiography and a novel method, tissue Doppler imaging (TDI) in detection of late or subclinical cardiotoxicity following anthracycline chemotherapy in long-term follow up. Forty women (31 to 65 years) were enrolled, who had not received anthracyclines previously and had normal cardiac function. The control group consisted of 20 healthy persons of similar age range. In addition to standard echocardiographic measurements, each patient underwent specific measurements (E-septum separation, pulmonary venous flow) as well. Furthermore, the myocardial velocity of numerous segments of the mitral anulus obtained with pulsed wave TDI was also detected over a two-year-long period. Systolic left ventricular function did not change significantly either in the study or in the control group. After one year, diastolic left ventricular function was impaired in 39 patients (97.5%), and 29 (72.5%) of these showed clear changes by means of the traditional E/A ratio and TDI. However, in ten patients (25%) the diastolic dysfunction could only be detected with TDI. At the end of the study diastolic dysfunction was detected in each patient, but in 13 patients (32.5%) the relaxation disorder could be revealed only with TDI. Detectable myocardial damage occurred in the study group as a result of anthracycline therapy. Our results confirmed our assumptions that TDI is a more precise and useful examination method than the traditional ones (E/A ratio or deceleration time) to demonstrate isolated diastolic dysfunction. TDI may become a regularly and more widely used noninvasive method to detect subclinical cardiotoxicity emerging after chemotherapy.     

神经内镜辅助去骨瓣血肿清除术治疗高血压脑出血患者的效果

目的：观察神经内镜辅助去骨瓣血肿清除术治疗高血压脑出血患者的效果。方法：选取2020年6月至2022年6月该院收治的100例高血压脑出血患者进行前瞻性研究,按随机数字表法将其分为对照组与研究组各50例。对照组采用小骨窗开颅术治疗,研究组采用神经内镜辅助去骨瓣血肿清除术治疗。比较两组手术相关指标水平、手术前后神经损伤指标[神经元特异性烯醇化酶（NSE）、胶质纤维酸性蛋白（GFAP）、中枢神经特异性蛋白（S100β）]水平、神经功能缺损程度[美国国立卫生研究院卒中量表（NIHSS）]评分、临床疗效和并发症发生率。结果：研究组手术时间、住院时间均短于对照组,术中出血量少于对照组,血肿清除率高于对照组,差异有统计学意义（P<0.05）;术后1周,两组NSE、GFAP、S100β水平均低于术前,且研究组均低于对照组,差异有统计学意义（P<0.05）;术后1个月,两组NIHSS评分均低于术前,且研究组低于对照组,差异有统计学意义（P<0.05）;研究组治疗总有效率为78.00%(39/50),高于对照组的54.00%(27/50),差异有统计学意义（P<0.05）;两组并发...     

银屑病皮损免疫病理表型特征及其体外维持

目的 研究银屑病皮损骨型表型及其体外维持。方法 检测代表银屑病病理特征的蛋白分子了,并观察培养后这些分子的变化。结果 银屑病皮损中角蛋白１６,１７,转谷酰酶,Ｉ,ＩＣＡＭ－１,ＨＬＡ－ＤＲ,β１整合素及ＯＫＭ－５增强表达,培养４８ｈ后和培养前基本相同。结论上述蛋白分子了的共同表达构成了银屑病皮损的免疫表型,这种表型在跨膜皮肤器官模型中４８ｈ培养可得到良好的维持。