第二届中国肿瘤介入与微创治疗大会将在上海召开

第二届中国肿瘤介入与微创治疗大会暨上海第三届肝癌综合介入诊疗国际会议(2011 CCIO)将于2011年4月15～17日在上海召开。本次会议由中华医学会放射学分会介入学组主办;复旦大学附属中山医院、上海市影像医学研究所、北京大学第一医院、中国医学科学院肿瘤医院及天津肿瘤医院承办;《当代医学-中国介入放射学》杂志协办。     

超声造影定量分析技术在早期鉴别兔VX2肝肿瘤消融后残癌与炎症带中的应用价值

目的 探讨超声造影定量分析技术在早期鉴别兔VX2肝肿瘤激光消融后癌残留与灶周炎症带中的价值.方法 取新西兰大白兔16只,在兔肝种植VX2瘤后制作肿瘤部分消融模型.在消融后1、3、7、14天对肿块区进行超声造影检查,超声检查仪器为东芝Aplioi900超声诊断仪,造影剂为SonoVue.参照最终病理结果,回放定帧图像,分...     

经腔镜前列腺癌根治术的手术护理

目的:探讨经腹腔镜前列腺癌根治术(LPR)的手术护理方法,使外科手术的术中护理紧跟医疗新技术的发展.方法:回顾性分析我院2013年4月至2015年4月28例采用经腹腔镜下腹膜外前列腺癌根治术的临床资料及护理经验.结果:28例实施腹腔镜下前列腺癌根治手术患者在手术期给予全面细致的护理均顺利完成,无一例因护理配合不佳而增加手术风险,医患均满意.手术平均时间2.5-5小时,术中平均出血量700ml,与经腹腔前列腺癌根治手术出血量相比少了200ml左右.所有患者均于术后7-14天拔出尿管,自主排尿正常.     

131I-美妥昔单抗联合动脉内化疗栓塞治疗原发性肝癌的内照射吸收剂量估算

Objective Metuximab is a specific monoclonal antibody F(ab')fragment targeted to the hepatocellular carcinoma(HCC)associated antigen of HAb18G/CD147.131I labeled metuximab has shown to be effective response on HCC in phase Ⅰ/Ⅱtrails.To evaluate the feasibility of 131I-metuximab combined with transarterial chemoembolization(TACE)is the treatment of HCC,the anthors estimated the radiation absorbed dose to organs.Methods 131I-metuximab(27.75 MBq/kg)and the mixture of anticancer drug and Lipiodol with interval 20 min later were administered to 21 patients with HCC via a transfemoral catheter.The pharmacokinetie and desimetric data were collected by means of venous blood samples.urine collections,and 4 or 5 γ-scintigraphies (SPECT) over7 d.The total amount of activity in percent of iniected activity (%ID)of main organ and the total body were calculated by regions of interest(ROI).The cumulated activities were determined from integration of the time-%ID curves using the SPSS 12.0 software.Absorbed doses to organ and red marrow were estimated according to the medical internal radiation dose (MIRD) formalism and blood-based marrow estimation with a red marrow-to-blood activity concentration ratio.The tumorto-no tumor ratio was calculated as well.Results A mean administered aetivity was 1.89 GBq per session (range 1.47-2.23 GBq).SPECT scans showed the significant accumulation of the radioconjugate in liver tumor and faint uptake in other organs until 14 d.Organ absorbed dose(n=12):the total absorbed dose to liver,spleen,thyroid,lungs,kidney and total-body was(3.19±1.01),(3.65±2.41),(3.61±2.40),(0.97±0.23),(0.96±0.35)and(0.57±1.55)Gy,with(0.55±0.09)Gy to the red marrow(n=7),respectively.From 2.88±1.11 to 1.64±0.39 were observed in tumor-to-liver ratio at 3 h to 168 h.Conclusion Internal absorbed dose estimation based on MIRD formalism is not only to establish reliable dose-response relationships for target tissue and dose-toxicity relationships for normal tissue but also to improve treatment planning in individual patient.     

As4S4 Induced Apoptosis in HeLa Cells and Its Molecular Mechanism

Objective To investigate the As4S4 induced growth inhibition and apoptosis in HeLa cells and its possible relationship with cyclooxygenase-2 (COX-2). Methods HeLa cells were treated with various concentrations (7.5, 15, 30, 60 mg/L) of As4S4 at different times (12, 24, 36, 48, 60 h). Cell growth was measured by MTT. Apoptosis was detected by double staining flow cytometry (FCM). Levels of PGE2 were measured by radioimmunoassay. The expression of COX-2 protein was examined by Western blot analysis. Results After treated with different concentrations of As4S4, the growth of HeLa cells was suppressed significantly in a dose-and time-dependent manner. The IC50 of 24 h was 30 mg/L (P＜0.01). As4S4 induced apoptosis with apoptosis rates at 8.13%-62.36% by flow cytometry (FCM) in a dose-dependent manners. The release of PGE2 was reduced in HeLa cells with the values being (70.56±2.03), (48.58±2.28), (29.25±1.57) and (18.02±1.04) respectively, significantly different compared with control group (3.15±0.01) (P＜0.01). As4S4 also inhibited the activity and expression of COX-2 in a dose dependent manner and down-regulated the expression of COX-2 protein greatly. Conclusion As4S4 could inhibit the proliferation and increase apoptosis in human HeLa cells. These effects may depend on the inhibition of the expression of COX-2 and PGE2 by As4S4.     

快速康复外科理念在结直肠癌围手术期中应用疗效的Meta分析

目的通过Meta分析系统评价快速康复外科理念(Enhanced Recovery After Surgery, ERAS)在结直肠癌围手术期中的应用疗效。方法检索多个国内外文献数据库中涉及ERAS理念在结直肠癌围手术期中应用效果的随机对照试验,检索时间为从建库至2020年10月。由2名研究共同完成文献筛选、数据提取和质量评价,利用Rev Man 5.3软件进行分析。结果纳入24篇随机对照试验,共3045例患者,其中ERAS组1526例,传统组1519例。与常规护理组相比,快速康复外科组的患者术后的并发症发生率、术后首次排气时间、术后首次排便时间、首次下床活动时间、术后住院时间以及住院费用均降低明显,差异均有统计学意义(均P<0.05)。结论 ERAS在一定程度上能加速结直肠癌患者术后肠功能的恢复、缩短患者术后住院的时间、降低患者术后并发症的发生率;同时能减轻患者的经济负担,建议在临床中进一步推广和应用。     

国产水溶性树酯包埋在肾活检切片的应用

肾脏疾病特别是肾小球疾病的病理诊断,要求高质量的病理切片和多种染色方法,并需与免疫病理技术和超微病理技术相配合,方能作出准确的诊断.将肾穿刺活检的同一肾组织,应用多种病理技术进行研究和观察.是肾脏病理领域内探讨的课题。作者在骨髓活检塑料包埋切片的启发下,在肾活检病理诊断中,应用了国产水溶性树酯包埋剂,进行了光镜、免疫组化的观察,大大优于既往的石蜡包埋方法,可以提高肾活检病理诊断的准确率。     

甲状腺乳头状瘤细胞核形态及DNA含量的意义(摘要)

甲状腺乳头状瘤细胞核形态及ＤＮＡ含量的意义（摘要）刘嵘卢于源张桂芬孙智才魏国红（北京军区第２５４医院病理科，天津３００１４２）应用ＤＮＡ图像分析仪检测了５１例甲状腺乳头状癌、乳头状腺瘤及乳头状增生细胞核ＤＮＡ含量和形态学参数。其结果显示，乳头状癌组与...     

芍药甘草汤结合运动训练治疗脑卒中后肌痉挛临床研究

目的:观察芍药甘草汤结合运动训练治疗脑卒中后肌痉挛的临床疗效。方法:选择2009年3月—2011年3月本院脑卒中后肌痉挛患者80例,随机分为对照组和治疗组各40例,对照组进行运动治疗,治疗组采用运动治疗配合芍药甘草汤药物治疗。比较两组患者治疗前后肢体活动能力、生活自理能力及肢体张力改善情况。结果:治疗组肢体功能较对照组显著提高(P0.05);治疗组侧屈肌IEMG和RMS值较对照组明显降低(P0.05)。结论:芍药甘草汤能够改善脑卒中后肌痉挛情况,降低肌张力。