排序方式: 共有50条查询结果,搜索用时 0 毫秒
31.
32.
目的探讨全胸腔镜肺叶切除术治疗对早期非小细胞肺癌患者术后康复及VAS评分的影响。方法选取我院2018年11月至2019年11月收治的早期非小细胞肺癌患者72例,随机分为两组各36例。观察组采用全胸腔镜肺叶切除术治疗,对照组采用常规开胸肺叶切除术治疗。比较两组的手术、康复指标,术后VAS评分以及并发症发生率。结果术后1~5 d,观察组的VAS评分均显著低于对照组(P<0.05)。观察组的引流时间、住院时间显著短于对照组,术中出血量显著少于对照组(P<0.05)。观察组的并发症发生率为5.56%,显著低于对照组的27.78%(P<0.05)。结论全胸腔镜肺叶切除术治疗早期非小细胞肺癌患者,可明显减轻患者疼痛,缩短住院时间,减少并发症,促进术后康复,具有较高的临床应用价值。 相似文献
33.
The transforming growth factor β1(TGF-β1) and CD8-positive T cells are two important immune factors that function at opposite directions. The purpose of this study was to verify the relationship between the two factors and their associations with long-term effects of adjuvant chemotherapy or endocrine therapy in breast cancer. Expression of TGF-β1 precursor and CD8 was immunohistochemically detected on surgically-obtained tumor samples of 130(stageⅠ–Ⅲ) invasive breast carcinomas from Chinese subjects, who were followed up for a mean time of 112 months. Interstitial CD8-positive cells and TGF-β1 precursor-positive cells adjacent to tumor nests were counted. Infiltration of CD8-positive lymphocytes into tumor nests and TGF-β1 precursor expression in tumor cells were observed and survival analysis was performed. Our results showed that density of interstitial CD8-positive lymphocytes was an independent adverse prognostic factor for distant disease-free survival(DDFS)(HR=8.416, 95% CI=1.636–43.292, P=0.011) in hormone receptor-positive patients who were on adjuvant endocrine therapy. For breast cancer patients who did not receive adjuvant chemotherapy, those without infiltration of CD8-positive cells into tumor nests had a shorter overall survival(OS) than their counterparts with CD8-positive cell infiltration into tumor nests(Log-Rank, P=0.003). But OS of patients without infiltration of CD8-positive cells into tumor nests was significantly prolonged by adjuvant chemotherapy(Log-Rank, P=0.013) and paralleled that of patients with CD8-positive cell infiltration. Although OS was shorter in the tumor cell TGF-β1 precursor(t-TGF-β1-pre)-positive patients than in the negative patients in patients without recieiving chemotherapy(P=0.053), OS of t-TGF-β1-pre-positive patients was significantly prolonged by adjuvant chemotherapy(P=0.035) and was longer than that of t-TGF-β1-pre-negative patients. Analysis showed that t-TGF-β1-pre was an independent positive prognostic factor for DDFS(HR=0.392 95% CI=0.157–0.978, P=0.045) in patients who received adjuvant chemotherapy. This study suggested that density of interstitial CD8-positive lymphocytes was of prognostic value in hormone receptor-positive patients who received adjuvant endocrine therapy. Our study verified that adverse immunologic signatures consisting of absence of CD8-positive cells in tumor nests or expression of TGF-β1 precursor in tumor cells in breast cancer were associated with worse prognosis and significantly improved long-term survival with adjuvant chemotherapy, respectively. 相似文献
34.
目的探讨S-100β和MBp在不同病情程度动脉瘤性蛛网膜下腔出血患者血清中的表达情况。方法颅内动脉瘤破裂所致的蛛网膜下腔出血患者40例,按Hunt-Hess分级分为3组,其中A组(HuntⅠ~Ⅱ级)18例,B组(HuntⅢ级)14例,C组(HuntⅣ—Ⅴ)8例。另外选取15例健康体检者作为对照组。所选患者均于入院第1天抽取空腹外周静脉血5ml,对照组抽血1次。离心取血清,采用ELISA法检测血清中S-100β和MBP的含量。结果A组患者血中MBP含量与对照组差异无显著性(P〉0.05或P〈0.01),S-100β含量与对照组差异有显著性(P〈0.05);B组、C组患者S-100β和MBP含量与对照组差异均有显著性(P〈0.05)。结论动脉瘤性蛛网膜下腔出血后血清S-100β和MBP含量可以监测颅内动脉瘤患者病情严重程度。预测预后情况。 相似文献
35.
目的:探讨序贯性肠内营养治疗(ENT)在重症急性胰腺炎(SAP)病人治疗中的应用及临床效果.方法:将41例确诊为SAP并保守治疗的病人随机分为两组.研究组(n=21)采用短肽型EN制剂过渡至整蛋白型EN制剂的序贯性ENT方案;对照组(n=20)直接采用整蛋白型EN制剂的ENT方案,喂养过程按照相关指南实施.比较两组病人达到目标能量时间、喂养并发症的发生率、同期营养指标情况以及平均入住ICU时间的差异.结果:两组病人在一定时间内均能达到目标热量.研究组病人达到目标能量的时间早于对照组(P<0.05);研究组病人喂养并发症的发生率明显低于对照组(P<0.05);研究组病人营养指标改善情况明显好于对照组(P<0.05);研究组平均入住ICU时间短于对照组,但差异无统计学意义(P>0.05). 结论:序贯性ENT在SAP病人治疗中耐受性更好,能更快地改善病人的营养状况. 相似文献
36.
目的:观察参麦、喘可治注射液对人类体外不同器官细胞增殖的影响,以期发现其潜在的毒性和靶器官.方法:应用人类多器官细胞共培养模型,观察参麦、喘可治注射液分别作用24、48、72 h后,对WI-38、HepG2、HEK293、SH-SY5Y和HCF细胞增殖的影响.结果:参麦和喘可治注射液分别处理24、48、72 h后,两种药物的高剂量均抑制所有细胞的增殖;在两种药物处理后的各时点各种细胞的相对增殖率均随剂量的降低而升高、并有较好的剂量-效应关系.处理48、72 h后,次低~高剂量的参麦注射液均抑制WI-38细胞增殖,中剂量2组~高剂量组中的该药则对HEK293细胞的增殖均有抑制作用,中剂量1组~高剂量组中的该药可抑制HepG2和SH-SY5Y这两种细胞的增殖.喘可治注射液处理72 h后,次低~高剂量均抑制WI-38细胞增殖.结论:多器官细胞共培养模型发现两种药物对人胚肺均可能具有潜在的毒性,参麦注射液可能还对人胚肾有潜在的毒性;较大剂量的参麦注射液可能具有肝脏和神经毒性. 相似文献
37.
38.
目的 通过生物信息学分析核糖核酸酶A家族成员2(RNASE2)基因与胶质瘤免疫浸润水平及临床预后的关系。方法 通过生物信息分析获取癌症基因组图谱(TCGA)及中国胶质瘤基因组图谱(CGGA)数据库中RNASE2基因在胶质瘤中的表达情况,并分析RNASE2基因与胶质瘤预后、免疫浸润的关系及相应的信号通路。结果 RNASE2基因在胶质瘤中的表达水平高于癌旁组织(P﹤0.05)。RNASE2基因表达水平在世界卫生组织(WHO)Ⅱ级、WHOⅢ级、WHOⅣ级胶质瘤中依次递增,且在复发胶质瘤中的表达水平明显高于原位胶质瘤,差异均有统计学意义(P﹤0.01)。RNASE2低表达的胶质瘤患者生存情况明显优于RNASE2高表达患者,差异有统计学意义(P﹤0.01)。RNASE2 mRNA表达水平与CD8+T细胞呈负相关,与调节性T细胞呈正相关(P﹤0.05)。富集分析显示,RNASE2与免疫、炎症调控的信号通路相关。结论 RNASE2基因在胶质瘤中表达上调,影响胶质瘤免疫浸润水平,导致免疫微环境失衡,进而造成不良预后。表明RNASE2的转录水平可作为预测胶质瘤预后和免疫浸润的生物标... 相似文献
39.
目的:探讨大肠癌中BORIS蛋白的表达与肿瘤病理特征的关系。方法:应用免疫组织化学方法研究(60)例大肠癌组织及其配对的(40)例切缘正常大肠组织BORIS的表达情况,比较BORIS在不同大肠组织中表达的差异及其与大肠癌病理因素之间的关系。结果:大肠癌组织中BORIS蛋白表达阳性率明显高于切缘正常大肠组织(P<0.05),BORIS蛋白表达阳性率与肿瘤大小、浸润深度、Dukes分期、淋巴结转移、分化程度有关(P<0.05);与患者年龄、性别、肿瘤发生部位无关(P>0.05)。结论:BORIS过量表达可能在大肠癌的发生、发展过程中起重要作用,可能用于大肠癌辅助诊断。 相似文献
40.