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排序方式: 共有6013条查询结果,搜索用时 15 毫秒
21.
Lorena Villalba-Heredia Cristina Comeras-Chueca Alejandro Gonzlez-Agüero Daniel Domingo-del-Val Pilar Calmarza Germn Vicente-Rodríguez Jos A. Casajús ngel Matute-Llorente 《Nutrients》2021,13(5)
Childhood obesity has become a major global health problem. Vitamin D deficiency and poor cardiorespiratory fitness are highly prevalent in children with overweight or obesity, but little is known about their relationships. In this study, we aimed to analyze the relationship between serum 25-hydroxyvitamin D (25(OH)D) and cardiorespiratory fitness parameters in prepubertal obese and overweight children. A cross-sectional design with a sample of 57 prepubertal children, aged 9–11 years, with overweight or obesity was used. The fasting concentration of 25(OH)D was analyzed with a chemiluminescent microparticle immunoassay. Fat and lean body masses were determined by using DXA. Maximal oxygen uptake (VO2max) was measured with the maximal treadmill test. A total of 68.4% of the sample had sufficient levels of 25(OH)D. As expected, their cardiorespiratory fitness was poor compared with that of normal-weight children, but 60% of the group exceeded the median obesity-specific reference values. No differences were found between the sexes for relative VO2max or 25(OH)D levels. Moreover, no correlations were found between 25(OH)D and body composition or cardiorespiratory parameters for sex or vitamin D groups. Vitamin D status seems not to be directly related to body composition or cardiorespiratory fitness in prepubertal overweight or obese children. 相似文献
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Brenes Monge Alexander Fernández Elorriaga María Poblano Verástegui Ofelia Valdez Santiago Rosario Martínez Nolasco Manuel A. Yáñez Álvarez Iraís Saturno Hernández Pedro J. 《Maternal and child health journal》2021,25(4):565-573
Maternal and Child Health Journal - To identify and describe the frequency and characteristics of disrespect and abuse practices towards women during facility-based delivery in four hospitals in... 相似文献
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Cobb Cory L. Salas-Wright Christopher P. John Rachel Schwartz Seth J. Vaughn Michael Martínez Charles R. Awad Germine Pinedo Miguel Cano Miguel Ángel 《Prevention science》2021,22(3):397-407
Prevention Science - We examined national trends and mental health correlates of discrimination among Latinos in the USA. We used data from two nationally representative surveys based on the... 相似文献
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Zrubka Zsombor Vékás Péter Németh Péter Dobos Ágota Hajdu Ottó Kovács Levente Gulácsi László Hibbard Judith Péntek Márta 《The European journal of health economics》2022,23(8):1341-1355
The European Journal of Health Economics - Patient activation comprises the skills, knowledge and motivation necessary for patients’ effective contribution to their care. We adapted and... 相似文献
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Aránzazu Caballero-Marcos Magdalena Salcedo Roberto Alonso-Fernández Manuel Rodríguez-Perálvarez María Olmedo Javier Graus Morales Valentín Cuervas-Mons Alba Cachero Carmelo Loinaz-Segurola Mercedes Iñarrairaegui Lluís Castells Sonia Pascual Carmen Vinaixa-Aunés Rocío González-Grande Alejandra Otero Santiago Tomé Javier Tejedor-Tejada José María Álamo-Martínez Luisa González-Diéguez Flor Nogueras-Lopez Gerardo Blanco-Fernández Gema Muñoz-Bartolo Francisco Javier Bustamante Emilio Fábrega Mario Romero-Cristóbal Rosa Martin-Mateos Julia Del Rio-Izquierdo Ana Arias-Milla Laura Calatayud Alberto A. Marcacuzco-Quinto Víctor Fernández-Alonso Concepción Gómez-Gavara Jordi Colmenero Patricia Muñoz José A. Pons the Spanish Society of Liver Transplantation 《American journal of transplantation》2021,21(8):2876-2884
The protective capacity and duration of humoral immunity after SARS-CoV-2 infection are not yet understood in solid organ transplant recipients. A prospective multicenter study was performed to evaluate the persistence of anti-nucleocapsid IgG antibodies in liver transplant recipients 6 months after coronavirus disease 2019 (COVID-19) resolution. A total of 71 liver transplant recipients were matched with 71 immunocompetent controls by a propensity score including variables with a well-known prognostic impact in COVID-19. Paired case–control serological data were also available in 62 liver transplant patients and 62 controls at month 3 after COVID-19. Liver transplant recipients showed a lower incidence of anti-nucleocapsid IgG antibodies at 3 months (77.4% vs. 100%, p < .001) and at 6 months (63.4% vs. 90.1%, p < .001). Lower levels of antibodies were also observed in liver transplant patients at 3 (p = .001) and 6 months (p < .001) after COVID-19. In transplant patients, female gender (OR = 13.49, 95% CI: 2.17–83.8), a longer interval since transplantation (OR = 1.19, 95% CI: 1.03–1.36), and therapy with renin–angiotensin–aldosterone system inhibitors (OR = 7.11, 95% CI: 1.47–34.50) were independently associated with persistence of antibodies beyond 6 months after COVID-19. Therefore, as compared with immunocompetent patients, liver transplant recipients show a lower prevalence of anti-SARS-CoV-2 antibodies and more pronounced antibody levels decline. 相似文献
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P53 overexpression as an indicator of overall survival and response to treatment in osteosarcomas 总被引:5,自引:0,他引:5
Pápai Z Féja CN Hanna EN Sztán M Oláh E Szendrôi M 《Pathology oncology research : POR》1997,3(1):15-19
The p53 gene located at chromosome 17pl3 is found to be altered (allelic loss or other mutation) in multiple human cancers,
including osteosarcomas. The mutated gene produces a protein with a prolonged half-life thus rendering it detectable by conventional
immunohistochemistry. We examined the correlation between p53 expression and clinical prognosis as well as response to therapy.
Twentyone patients with previously untreated and histologically verified highly malignant osteosarcoma were used for this
study. Biopsy material taken both prior to the start of COSS 91 protocol and at the time of surgery (ten weeks later) was
examined for alterations in p53 protein expression and drug resistance. Two patients who had strong (+++) p53 protein expression
and three others who became positive during the chemotherapy had significantly worse prognosis (all of them died within one
year) than those who showed no p53 expression both at biopsy and after chemotherapy (all 11 patients are alive, average follow-up
time: 3.5 years). All patients who showed any kind of positive p53 protein expression on initial biopsy were non-respon-ders
to chemotherapy. In contrast, 69% (9 out of 13) of those who exhibited no p53 expression on initial biopsy were responders
or intermediate responders to chemotherapy. We concluded that p53 expression may be a useful prognostic factor in osteosarcomas.
The direct correlation between p53 positive expression and resistance to therapy can help in identifying patients who are
in need of a more vigorous or different chemotherapeutical protocol. 相似文献