Crevicular temperature rises stimulated by plaque formation

In nineteen subjects, temperatures were recorded thermo-electrically in the vestibular and proximal crevices of fifty-nine teeth. It was found that the formation of a new plaque was followed by a rise in crevicular temperature. In addition, it was found that the normal as well as the abnormal crevicular temperatures were higher in the mandible than in the maxillae.     

Genetic Studies in Varicocele Infertility: I: Pedigree, Nuclear Sex and Seminal Nucleic Acids

The hereditary predisposition of varicocele men to develop infertility was investigated in a controlled study involving 30 infertile varicocele patients. Analysis of the pedigree charts, determination of sex chromatin constitution, and biochemical measurement of seminal nucleic acid (DNA/RNA) were undertaken. Sibs and Kins of infertile varicocele patients showed various developmental anomalies particularly of the genito-crural area. cocele formation while the gonads develop in the normal line. Such condition may be represented in fertile men with clinically detectable varicocele. In addition, the postulated defective gene in VI patients may interfere as well with the normal development of the mesenchyme-derived interstitial cells of Leydig. Defective testicular steroid hormone biosynthesis thus obtained may explain the reported decrease in androgen level in peripheral blood, sexual impotentia and accessory genital gland dysfunction (Raboch and Starka - 1971; Comhaire and Vermeulen - 1975). Moreover, being androgen dependent (Lacy - 1973), spermatogenesis may display abnormal patterns due to lowered intratesticular androgen concentration (Rodriguez-Rigau et al. - 1978). The outcome and severity of spermatogenic derangement may depend partially on the severity of disordered androgen biosynthesis. The present work showed significant decrease in sperm count, motility, normal forms and nucleic acid content (DNA and RNA) of the seminal fluid in VI patients. The decrease in the amount of DNA per millilitre of seminal fluid in VI patients may be explained by the decrease in sperm population (oligozoospermia). The decrease in the amount of RNA per millilitre of seminal fluid in VI patients may be due to the total decrease in cellular content of the seminal fluid.(ABSTRACT TRUNCATED AT 250 WORDS)     

Mismatch repair and treatment resistance in ovarian cancer

Background  

The treatment of ovarian cancer is hindered by intrinsic or acquired resistance to platinum-based chemotherapy. The aim of this study is to determine the frequency of mismatch repair (MMR) inactivation in ovarian cancer and its association with resistance to platinum-based chemotherapy.     

Population pharmacokinetics of digoxin in Egyptian pediatric patients: impact of one data point utilization

A population pharmacokinetic (PK) study was designed to estimate the PK parameters of digoxin among a selected group of Egyptian pediatric patients (n = 30) with mean age +/- SD and body weight +/- SD of 8.88 +/- 3.01 years and 23.9 +/- 5.8 kg, respectively. All patients had heart failure and were maintained on digoxin given orally. Nonlinear mixed effect modeling software version 5 (NONMEM Project Group, San Francisco, CA) and one-compartment modeling were used for fitting the data. A one-trough steady-state plasma concentration level of digoxin was used in the analysis. The population mean estimates for clearance (CL/f) and volume of distribution (V/f), in which f represents oral bioavailability, were 8.61 L/h and 450 L, respectively. Because of the limited number of samples per patient, regression analysis could not detect a correlation between patient covariates and estimated PK parameters. The analysis did not converge to obtain good parameter estimates. At least two samples per patient should be used to improve the PK estimation and allow better analysis of the relation between the potential covariates and estimated PK parameters.     

Assessment of bone quality using buccal and palatal autogenous cortical shells harvested from two different mandibular donor sites for maxillary alveolar ridge augmentation: a histomorphometric randomized clinical trial

Oral and Maxillofacial Surgery - This study aims to compare the quality of free autogenous bone grafts harvested from two different mandibular donor sites, used as onlay shells to augment...     

The secretion of plasminogen activators by human myeloid leukemic cells in vitro

Peripheral blood cell preparation from 23 normal subjects and 72 patients with acute and 32 patients with chronic myeloid leukemia were cultured in vitro and released plasminogen activators were analyzed. The quantity of plasminogen activator secreted by leukemic cells varied widely and could not be correlated with the clinical severity of the disease. Immunochemical and electrophoretic techniques have been used to show that normal peripheral blood granulocytes released exclusively urokinase-like plasminogen activator, whereas leukemic cells secreted either urokinase or a tissue activator-like enzyme. The molecular species of enzyme released by acute myeloid leukemic cells may serve as a diagnostic marker of relevance to the management of this disease, since patients with acute myeloid leukemia whose cells released only tissue plasminogen activator did not respond to combination chemotherapy. Tissue plasminogen activators released by leukemic cells may display an unusual electrophoretic pattern that resembles that shown by urokinase. Immunochemical procedures are therefore essential for the correct identification of these enzymes.