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991.
We examined MMR vaccine uptake among ethnic groups in Birmingham, UK between 1994 and 2000, a period incorporating adverse MMR vaccine publicity. From 1994 to 2000 overall uptake: (1) fell significantly from 91.1% in 1994 to 89.8% (chi(2) for trend p<0.001) in 2000, (2) in Asian children significantly increased (chi(2) for trend p<0.001), and (3) in White children significantly decreased (chi(2) for trend p<0.001). Differences between ethnic groups with the highest (Asian) and the lowest (Black Caribbean) uptake rates increased from 2.1% in 1994 (p=ns) to 6.8% in 2000 (p<0.001). This study suggests underlying ethnic inequalities in MMR vaccine uptake and differential response to adverse vaccine publicity. 相似文献
992.
Tapiainen T Prevots R Izurieta HS Abramson J Bilynsky R Bonhoeffer J Bonnet MC Center K Galama J Gillard P Griot M Hartmann K Heininger U Hudson M Koller A Khetsuriani N Khuri-Bulos N Marcy SM Matulionyte R Schöndorf I Sejvar J Steele R;Brighton Collaboration Aseptic Meningitis Working Group 《Vaccine》2007,25(31):5793-5802
993.
Kramarz PE de Vaufleury A Zygmunt PM Verdun C 《Environmental toxicology and chemistry / SETAC》2007,26(1):73-79
To determine the effect of nematode infection on the response of snails to selected toxins, we infected Helix aspersa with 0-, 0.25-, 1-, or 4-fold the recommended field dose of a commercial nematode application for agricultural use. In the first experiment, the snails also were exposed to cadmium via food and soil at concentrations of 0, 30, 60, 120, or 240 mg/kg in a full-factorial design. In the second experiment, snails were infected with nematodes and also fed either Bt (expressing Bacillus thuringiensis toxin) maize or non-Bt maize. The snails were weighed at the beginning and end (after four weeks) of the experiments, and mortality was checked daily. Neither exposure of snails to nematodes nor exposure of snails to cadmium or Bt toxin affected the survival rates of snails. The number of dead snails was highest for combinations of nematode treatments with cadmium concentrations of 120 and 240 mg/kg. In both experiments (Bt and cadmium), the growth rate decreased with increasing nematode dose. The Bt maize was not harmful to the snails in the absence of nematodes, but infected snails grew faster when fed non-Bt maize. The growth rate of snails exposed to cadmium decreased with exposure to increasing Cd concentrations and differed significantly between the no-nematode treatment and the treatments with nematode doses of one- and fourfold the recommended field dose. Snails treated with the highest dose of nematodes accumulated the highest cadmium concentrations. 相似文献
994.
995.
Mary Carmelle Philogene Sheng Zhou Bonnie E. Lonze Serena Bagnasco Sami Alasfar Robert A. Montgomery Edward Kraus Annette M. Jackson Mary S. Leffell Andrea A. Zachary 《Human immunology》2018,79(4):195-202
Retrospective studies of angiotensin II type 1 receptor antibodies (AT1R-Ab) and anti-endothelial cell antibodies (AECA) have linked these antibodies to allograft injury. Because rising healthcare costs dictate judicious use of laboratory testing, we sought to define characteristics of kidney transplant recipients who may benefit from screening for non-HLA antibodies. Kidney recipients transplanted between 2011 and 2016 at Johns Hopkins, were evaluated for AT1R-Ab and AECA. Pre-transplant antibody levels were compared to clinical and biopsy indications of graft dysfunction. Biopsies were graded using the Banff' 2009–2013 criteria. AT1R-Ab and AECA were detected using ELISA and endothelial cell crossmatches, respectively. AT1R-Ab levels were higher in patients who were positive for AECAs. Re-transplanted patients (p?<?0.0001), males (p?=?0.008) and those with FSGS (p?=?0.04) and younger (p?=?0.04) at time of transplantation were more likely to be positive for AT1R-Ab prior to transplantation. Recipients who were positive for AT1R-Ab prior to transplantation had increases in serum creatinine within 3?months post-transplantation (p?<?0.0001) and developed abnormal biopsies earlier than did AT1R-Ab negative patients (126?days versus 368?days respectively; p?=?0.02). Defining a clinical protocol to identify and preemptively treat patients at risk for acute rejection with detectable non-HLA antibodies is an important objective for the transplant community. 相似文献
996.
van der Zijden JP Wu O van der Toorn A Roeling TP Bleys RL Dijkhuizen RM 《NeuroImage》2007,34(4):1650-1657
Loss of function and subsequent spontaneous recovery after stroke have been associated with physiological and anatomical alterations in neuronal networks in the brain. However, the spatiotemporal pattern of such changes has been incompletely characterized. Manganese-enhanced MRI (MEMRI) provides a unique tool for in vivo investigation of neuronal connectivity. In this study, we measured manganese-induced changes in longitudinal relaxation rate, R(1), to assess the spatiotemporal pattern of manganese distribution after focal injection into the intact sensorimotor cortex in control rats (n=10), and in rats at 2 weeks after 90-min unilateral occlusion of the middle cerebral artery (n=10). MEMRI data were compared with results from conventional tract tracing with wheat-germ agglutinin horseradish peroxidase (WGA-HRP). Distinct areas of the sensorimotor pathway were clearly visualized with MEMRI. At 2 weeks after stroke, manganese-induced changes in R(1) were significantly delayed and diminished in the ipsilateral caudate putamen, thalamus and substantia nigra. Loss of connectivity between areas of the sensorimotor network was also identified from reduced WGA-HRP staining in these areas on post-mortem brain sections. This study demonstrates that MEMRI enables in vivo assessment of spatiotemporal alterations in neuronal connectivity after stroke, which may lead to improved insights in mechanisms underlying functional loss and recovery after stroke. 相似文献
997.
Population pharmacokinetics of subcutaneous C1‐inhibitor for prevention of attacks in patients with hereditary angioedema
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Dipti Pawaskar Michael A. Tortorici Bruce Zuraw Timothy Craig Marco Cicardi Hilary Longhurst H. Henry Li William R. Lumry Inmaculada Martinez‐Saguer Joshua Jacobs Jonathan A. Bernstein Marc A. Riedl Constance H. Katelaris Paul K. Keith Annette Feussner Jagdev Sidhu 《Clinical and experimental allergy》2018,48(10):1325-1332
998.
Vera Regitz-Zagrosek Christa Gohlke-Bärwolf Annette Geibel-Zehender Markus Haass Harald Kaemmerer Irmtraut Kruck Christoph Nienaber 《Clinical research in cardiology》2008,97(9):630-665
Ohne Zusammenfassung
Herausgegeben vom Vorstand der Deutschen Gesellschaft für Kardiologie – Herz- und Kreislaufforschung e.V. Bearbeitet im Auftrag
der Kommission für Klinische Kardiologie M. Borggrefe, M. B?hm, J. Brachmann, H.-R. Figulla, G. Hasenfu?, H.M. Hoffmeister,
A. Osterspey, K. Rybak, U. Sechtem, S. Silber 相似文献
999.
1000.