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891.
Marijo Bilusic Yu-Ning Wong 《Asian journal of andrology》2014,16(3):372-377
Angiogenesis is a very complex physiological process, which involves multiple pathways that are dependent on the homeostatic balance between the growth factors (stimulators and inhibitors). This tightly controlled process is stimulated by angiogenic factors, which are present within the tumor and surrounding tumor-associated stromal cells. The dependence of tumor propagation, invasion and metastasis on angiogenesis makes the inhibitors of new blood vessel formation attractive drugs for treating the malignancies. Angiogenesis can be disrupted by several distinct mechanisms: by inhibiting endothelial cells, by interrupting the signaling pathways or by inhibiting other activators of angiogenesis. This strategy has shown therapeutic benefit in several types of solid tumors, leading to Food and Drug Administration (FDA) approval of anti-angiogenic agents in the treatment of kidney, non-small cell lung, colon and brain cancers. Although no angiogenesis inhibitors have been approved for patients with metastatic prostate cancer, therapies that target new blood vessel formation are still an emerging and Dromising area of prostate cancer research. 相似文献
892.
893.
Martin C.S. Wong Jing Liu Shenglai Zhou Shiwei Li Xuefen Su Harry H.X. Wang Roger Y.N. Chung Benjamin H.K. Yip Samuel Y.S. Wong Joseph T.F. Lau 《International journal of cardiology》2014
Multimorbidity, defined as the presence of two or more chronic conditions, leads to a substantial public health burden. This study evaluated its association with adherence with cardiovascular medications in a Chinese population. 相似文献
894.
A. Hsieh P.X. Ong L. Molyneaux M.J. McGill M. Constantino T. Wu J. Wong D.K. Yue S.M. Twigg 《Diabetes research and clinical practice》2014
An earlier age of diagnosis (r = −0.28, p < 0.0001) and longer duration of type 2 diabetes (r = 0.26, p < 0.0001) were each found to correlate with higher HbA1c level, on analysis of a diabetes centre database in people under regular shared care. When combined, these biological variables strongly associate with the current HbA1c level. 相似文献
895.
896.
Woo So-Yeun Wong Chin Piow Win Nwet Nwet Lae Khine Zar Wynn Woo Bokyoung Elsabbagh Sherif Adel Liu Qian Qian Ngwe Hla Morita Hiroyuki 《Journal of natural medicines》2019,73(4):805-813
Journal of Natural Medicines - Jatropha multifida is a medicinal plant that belongs to the Euphorbiaceae family. Our investigation revealed that the chloroform extract of J. multifida stems showed... 相似文献
897.
898.
Abraham R. Tzafriri Felix Mahfoud John H. Keating Peter M. Markham Anna Spognardi Gee Wong Kristine Fuimaono Michael Böhm Elazer R. Edelman 《Journal of the American College of Cardiology》2014
Background
Renal denervation is a new interventional approach to treat hypertension with variable results.Objectives
The purpose of this study was to correlate response to endovascular radiofrequency ablation of renal arteries with nerve and ganglia distributions. We examined how renal neural network anatomy affected treatment efficacy.Methods
A multielectrode radiofrequency catheter (15 W/60 s) treated 8 renal arteries (group 1). Arteries and kidneys were harvested 7 days post-treatment. Renal norepinephrine (NEPI) levels were correlated with ablation zone geometries and neural injury. Nerve and ganglion distributions and sizes were quantified at discrete distances from the aorta and were compared with 16 control arteries (group 2).Results
Nerve and ganglia distributions varied with distance from the aorta (p < 0.001). A total of 75% of nerves fell within a circumferential area of 9.3, 6.3, and 3.4 mm of the lumen and 0.3, 3.0, and 6.0 mm from the aorta. Efficacy (NEPI 37 ng/g) was observed in only 1 of 8 treated arteries where ablation involved all 4 quadrants, reached a depth of 9.1 mm, and affected 50% of nerves. In 7 treated arteries, NEPI levels remained at baseline values (620 to 991 ng/g), ≤20% of the nerves were affected, and the ablation areas were smaller (16.2 ± 10.9 mm2) and present in only 1 to 2 quadrants at maximal depths of 3.8 ± 2.7 mm.Conclusions
Renal denervation procedures that do not account for asymmetries in renal periarterial nerve and ganglia distribution may miss targets and fall below the critical threshold for effect. This phenomenon is most acute in the ostium but holds throughout the renal artery, which requires further definition. 相似文献899.
Audrey Yi Tyan Peng Ira Agrawal Wan Yun Ho Yi-Chun Yen Ashley J. Pinter Jerry Liu Qi Xuan Cheryl Phua Katrianne Bethia Koh Jer-Cherng Chang Emma Sanford Jodie Hon Kiu Man Peiyan Wong David H. Gutmann Greg Tucker-Kellogg Shuo-Chien Ling 《Proceedings of the National Academy of Sciences of the United States of America》2020,117(46):29101
900.
Ishikawa Shigeo Wong David T. W. Sugimoto Masahiro Gleber-Netto Frederico Omar Li Feng Tu Michael Zhang Yong Akin David Iino Mitsuyoshi 《Clinical oral investigations》2019,23(9):3557-3563
Clinical Oral Investigations - To identify salivary metabolite biomarkers to differentiate patients with oral squamous cell carcinoma and oral epithelial dysplasia (OSCC/OED) from those with... 相似文献