软骨块内固定术结合持续被动活动治疗新鲜髌骨软骨骨折

目的 探讨新鲜髌骨软骨骨折的治疗方法。方法 对新鲜髌骨软骨骨折１１例,施行骨折的游离软骨块复位内固定,术后应用持续被动活动装置活动膝关节５周。结果 经平均２８个月的随访,１１例中,术后膝关节功能优９例,良１例,优良率９０．９％。结论新鲜髌骨软骨骨折采用游离软骨块复位内固定和ＣＰＭ治疗是可行的,疗效满意。     

Pharmacotechnical and analytical preformulation studies for cannabidiol orodispersible tablets

Obtaining orodispersible tablets (ODT) containing substances from the second Biopharmaceutical Class has raised concerns as the dissolution test is challenging. This study aimed to select suitable excipients for developing orodispersible tablets containing cannabidiol (CBD) by direct compression method. No similar studies were found in the literature. Excipients from different classes were characterized using the SeDeM-ODT tool: fillers – lactose (LCT) and microcrystalline cellulose (CelMC), sweeteners – sorbitol (SRB) and mannitol (MNT), disintegrants – sodium starch glycolate (SSG), sodium croscarmellose (CCS), soy polysaccharides (Emcosoy® – EMCS) and two co-processed excipients (Prosolv®-ODT G2 – PODTG2 and Prosolv® EasyTab sp – PETsp). Drug compatibility with excipients in binary mixtures (1:1) was verified by Differential Scanning Calorimetry (DSC) and Fourier Transform-Infrared (FTIR) spectroscopy. Using the SeDeM-ODT expert system, the fillers and the co-processed excipients showed good properties regarding compressibility and disintegration behavior. Also, the DSC and FTIR results showed that small or no interactions between the CBD and the excipients took place.     

Diagnosis of femoral pseudoaneurysm using 2-dimensional and Doppler echography

Femoral artery pseudoaneurysm was found by combined 2D, pulsed and continuous wave Doppler echography in 10 out of 16 patients with hematoma formation following cardiac catheterization. The typical features included an echofree area communicating with the femoral artery through a narrow neck. There was a low velocity systolic flow in the pseudoaneurysm and a high velocity systolic and reverse diastolic flow in the neck.     

杭州市2009-2011年儿童急性下呼吸道感染病原菌分布及耐药性分析

急性下呼吸道感染是儿童常见病和多发病,一般以细菌感染多见,但病原菌分布特点随着年代而不断变迁.为调查儿童下呼吸道感染病原菌的种类及耐药情况,我们对2009年11月-2011年10月收治杭州市第一人民医院儿科的急性下呼吸道感染患儿进行痰培养,对其病原菌分布及耐药情况进行统计分析.     

丹参病毒病病原鉴定研究

目的 鉴定我国中草药丹参病毒病的病原及其种类。方法 从自然感染引起花叶、矮化、褪绿和斑驳的丹参植株上分离病毒病原，进行生物学接种、电镜观察、双抗体夹心酶联免疫吸附测定、逆转录聚合酶链式反应及基因克隆和序列分析。结果 通过指示植物症状、电镜下病毒粒体形状和血清学反应发现病毒分离物与黄瓜花叶病毒有较近的亲缘关系，初步将该病毒分离物鉴定为黄瓜花叶病毒。通过逆转录聚合酶链式反应及基因克隆和序列分析，证明该病毒分离物为一个黄瓜花叶病毒新株系。结论 感染丹参的病毒病原为黄瓜花叶病毒，这是首次在我国中草药丹参上发现黄瓜花叶病毒。     

Diltiazem provides higher internal mammary artery flow than nitroglycerin during coronary artery bypass grafting surgery.

OBJECTIVES: Perioperative internal mammary artery (IMA) vasospasm in patients undergoing coronary artery bypass grafting (CABG) surgery may lead to morbidity and mortality. Surgical stimulus is one of the common causes of IMA vasospasm. Preventive measures, beside treatment should be taken into consideration to obtain vasospasm free IMA. The effect of a pharmacologic agent on IMA flow when it is administered before harvesting the artery has not been documented. We designed a prospective randomized clinical study to compare the IMA free blood flows in patients receiving either diltiazem or nitroglycerin, starting infusion of study drugs before a surgical stimulus was applied to the IMA region and continuing throughout the isolation period. METHODS: Sixty patients undergoing elective CABG surgery with the left IMA received diltiazem (n=30, 0.05-0.1 mg/kg per hour) or nitroglycerin (n=30, 0.25-2.5 microg/kg per minute) in a randomized manner. Infusions of study drugs were started before applying a surgical stimulus to the IMA region and continued throughout the harvesting period. The first free flow was measured after IMA was cut above its bifurcation and the second after its distal segment was resected. Heart rate, temperature, mean arterial and central venous pressures were recorded. Data were analyzed with Student's t-test and Fischer's exact test. RESULTS: Preoperative and hemodynamic data were similar between the groups. The means of first and second IMA flows in patients treated with diltiazem (53.8+/-30.1 and 72.3+/-35.4 ml/min) were significantly higher than in those treated with nitroglycerin (25.7+/-16.2 and 48.9+/-23.8 ml/min; P=0.000, 0.004, respectively). IMA flows significantly increased after distal segment resection both in diltiazem (34%) and nitroglycerin groups (90%; P= 0.000, 0.000, respectively). CONCLUSIONS: Diltiazem infusion which started prior to harvesting provided higher IMA blood flow compared to nitroglycerin infusion. Considering the percentage of increases in flows after resection of distal segment, the most prone part to vasospasm, we assume that a certain amount of spasm occurred in IMA in spite of infusion of study drugs, such that less with diltiazem and more with nitroglycerin. Diltiazem plays more important role than nitroglycerin in the prevention of vasospasm.     

中医整体护理中风急性期30例效果与证型的研究

目的 :研究对中风急性期患者实施中医整体护理后效果与证型因素的关系 ,探讨在中医整体观念指导下对中风急性期病人实施辨证施护后各种证型的康复效果。方法 :用中医整体护理程序对 (观察组 )中风急性期 30例进行辨证施护 ,另 (对照组 )实施功能制护理 30例。结果 :中经络者护理质量效果明显优于中脏腑者 ,中医整体护理的效果也明显优于功能制护理     

Adsorptive stripping voltammetric methods for determination of aripiprazole

Anodic behavior of aripiprazole (ARP) was studied using electrochemical methods. Charge transfer, diffusion and surface coverage coefficients of adsorbed molecules and the number of electrons transferred in electrode mechanisms were calculated for quasi-reversible and adsorption-controlled electrochemical oxidation of ARP at 1.15 V versus Ag/AgCl at pH 4.0 in Britton–Robinson buffer (BR) on glassy carbon electrode. Voltammetric methods for direct determination of ARP in pharmaceutical dosage forms and biological samples were developed. Linearity range is found as from 11.4 μM (5.11 mg/L) to 157 μM (70.41 mg/L) without stripping mode and it is found as from 0.221 μM (0.10 mg/L) to 13.6 μM (6.10 mg/L) with stripping mode. Limit of detection (LOD) was found to be 0.11 μM (0.05 mg/L) in stripping voltammetry. Methods were successfully applied to assay the drug in tablets, human serum and human urine with good recoveries between 95.0% and 104.6% with relative standard deviation less than 10%.     

The role of Integra dermal regeneration matrix in skin replacement on the upper extremity

Authors report the application of Integra dermal regeneration matrix in 10 patients in 12 indications (ages 25-74 years, 6 female and 4 male patients). The smallest reconstructed area was 6 cm2, the largest was 500 cm2. Skin coverage was needed on the lower arm in two patients, on the lower arm and the hand in two patients and on the hand in six patients. Skin grafting onto the neodermis was made on days 19-25. The take rate of Integra was equal or higher than 97%, and the take rate of the skin graft was equal or higher than 90%. Integra dermal regeneration template proved to be suitable for the management of complex wounds on the hands and upper extremities.     

冯氏脊柱定点旋转复位法调整胸椎治疗肩周炎临床观察

肩关节周围炎(简称肩周炎)是临床的常见病,好发于中老年人.常因外感风寒、潮湿、外力受伤等因素,致使肩关节囊、肩袖、韧带、肌肉、肌腱发生慢性无菌性炎症,其主要症状为肩部疼痛和肩关节活动受限.2008年5月-2011年9月笔者通过PALM触诊仪测定肩周炎患者双侧肩关节三维位置的差异[l],采用北京空军总医院冯氏脊柱定点旋转复位法调整胸椎,促进患者双侧肩关节三维位置对称的改善,并结合肩关节旋转袖相关肌肉的手法松解,治疗肩周炎100例,取得满意疗效,现报道如下.