Diagnosis and taxonomy of periodical psychosis

The concept and taxonomy of periodic psychosis still remains in controversy for the past 100 years. In China, it was first reported by Ji, and thereafter various rinds of terminology and views were given by different authors. In the presentation, clinical investigation and follow up were carried out in 62 cases. In many of these cases, the so-called "periodic psychosis" or "phasophrenia" was early clinical features of schizophrenia or manic-depression. In those cases with apparent symptoms and signs of diencephalic function, differential diagnosis should be carried out from organic brain syndrome. In a small number of cases, their clinical manifestations, conforming to previous diagnostic criteria, might be an uncommon syndrome. It was concluded by the authors that until now periodic could be considered only as a clinical syndrome rather than a disease entity.     

Monitoring effects of α-human atrial natriuretic polypeptide (α-hANP) on left ventricular function in patients with essential hypertension with a cardiac probe

The effects of -hANP on left ventricular function were studied with a cardiac probe in ten patients with essential hypertension. Our data showed that intravenous administration of -hANP significantly elevated left ventricular function. At 5 min, the elevation of EF, RCO, ER, RSV, PFR were 13.23% (P<0.02), 12.7 (P<0.02), 0.618 (P<0.02), 0.133 (P<0.05), 0.283 (P<0.01), respectively. At 10 min, the increase of EF, ER, were 11.07% (P<0.02) and 0.233 (P<0.01), respectively. Atriopeptin significantly reduced systolic and diastolic blood pressure from 2 min to 20 min (P<0.001–0.05).Supported by IAEA Grant No. 4062/RI/RB     

器官培养在研究人食管上皮癌变中的应用

将组织块置于明胶海绵上,摇摆器官培养,4～6周后成人食管粘膜仍保持良好的结构形态,具有活跃生长的上皮细胞和良好的腺体结构;将组织块贴壁,静置外植块—细胞培养,成人食管粘膜和胎儿食管组织块可存活2～3个月,提供大量生长旺盛的上皮细胞。成人食管癌旁粘膜培养利于观察细胞癌前改变,可能较易于诱发癌变;胎儿食管具有正常背景,利于研究细胞癌变的全过程.二者配合可组成研究人食管上皮癌变的完整体外实验系统。     

ALPHA-FETOPROTEIN VARIANTS AND THEIR CLINICAL SIGNIFICANCE

The molecular heterogeneity of serum alpha-fe- toprotein (AFP) in 36 patients was studied by lectin affinity-radioimmunoelectrophoresis. Two variants of AFP, concanavalin-A (Con-A) reactive and the Con-A nonreactive, were obtained. AFP in all 13 patients with hepatoma consisted of the two va- riants, but the Con-A reactive variant was the ma jor one. In 8 patients with benign liver disorder, however, only the Con-A reactive variant of AFP was detected. Over 50"70 0f AFP in 5 patients with yolk sac tumor was Con-A nonreactive. Thus, there were three different patterns of AFP variants. The clinical implications are discussed.     

2018年四川省成人糖尿病流行现状及其影响因素分析

目的 了解四川省成人常住居民糖尿病患病情况及其影响因素,为有效预防糖尿病,降低发病风险提供科学的依据。方法 2018年采用多阶段分层整群随机抽样的方法,抽取四川省18岁及以上常住居民进行身体测量、问卷调查、实验室检测。采用SAS 9.4分析四川省成人糖尿病流行情况和患病影响因素。结果 2018年四川省成人糖尿病患病率12.94%,其中男性患病率为13.09%,女性患病率为12.79%,差异无统计学意义(χ²=3.964,P=0.460); 年龄增长(与18～44岁组相比,75岁及以上OR=6.070,95%CI:3.792～9.716)、职业(与农业生产人员相比,离退休人员OR=1.781,95%CI:1.277～2.484)、锻炼频率(与每周0次相比,每周1～3次OR=0.439,95%CI:0.281～0.686)、血脂异常(OR=2.069,95%CI:1.693～2.528)、中心性肥胖(OR=1.938,95%CI:1.619～2.320)、高血压(OR=2.031,95%CI:1.583～2.606)、糖尿病家族史(OR=2.825,95%CI:1.658～4.813)是糖尿病患病的影响因素。结论 四川省糖尿病患病率处于较高水平,每周锻炼1～3次是预防糖尿病的保护因素,年龄增加、离退休人员、血脂异常、中心性肥胖、高血压、糖尿病家族史是糖尿病患病的危险因素,应进一步开展针对性的预防干预措施。     

基于数据包络分析的重庆市卫生资源配置效率研究

目的 分析2015—2020年重庆市各区县卫生资源配置效率,为重庆市提升资源配置效率提供参考。方法 采用数据包络分析的BCC模型和Malmquist指数对2015—2020年重庆市各区县卫生资源配置效率进行分析。结果 在2020年,重庆市卫生资源配置的综合效率不高,38个区县中有7个区县处于DEA有效状态,8个区县处于DEA弱有效状态;2015—2020年,重庆市全要素生产率指数均值为0.945,3个区县的全要素生产率指数大于1。结论 重庆市各区县卫生资源配置效率有待提高,重点在于提升技术进步水平;重庆市四大区域内部和四大区域之间卫生资源配置效率差异较大,需整合医疗卫生资源,重视医学科技创新和成果转化,达到提升卫生资源配置效率的目标。     

联合检测NSE、S100B、hs-CRP及NIHSS评分对急性脑梗死患者病情严重程度的评估价值

目的探讨联合检测神经元特异性烯醇化酶(NSE)、 S100B、超敏C-反应蛋白(hs-CRP)及美国国立卫生研究院卒中量表(NIHSS)评分对急性脑梗死患者病情严重程度的评估价值。方法选取我院2019年1月至2020年3月收治的急性脑梗死患者80例,依据改良Rankin量表(mRS)评分将其分为重度组(mRS评分≥3分,n=36)及轻度组(mRS评分<3分,n=44);另选取同期在我院行健康体检的40例患者作为健康组。比较三组的NSE、 S100B、 hs-CRP及NIHSS评分。结果重度组的NSE、 S100B、 hs-CRP、 NIHSS评分均高于轻度组及健康组(P <0.05);Pearson分析显示,NSE、 S100B、 hs-CRP及NIHSS评分与急性脑梗死病情严重程度呈正相关(r>0, P <0.05)。结论 NSE、 S100B、 hs-CRP及NIHSS评分与急性脑梗死患者病情严重程度呈正相关,联合检测具有客观性。     

Regional Differences in the Prevalence of Anaemia and Associated Risk Factors among Infants Aged 0–23 Months in China: China Nutrition and Health Surveillance

Infantile anaemia has been a severe public health problem in China for decades. However, it is unclear whether there are regional differences in the prevalence of anaemia. In this study, we used data from the China Nutrition and Health Surveillance (CNHS) to assess the prevalence of anaemia and the risk factors associated with its prevalence in different regions. We included 9596 infants aged 0–23 months from the CNHS 2013 database. An infant was diagnosed with anaemia if he/she had a haemoglobin concentration of <110 g/L. We used multivariate logistic regression to investigate the potential risk factors associated with the development of anaemia. We found that anaemia was present in 2126 (22.15%) of the infants assessed. Approximately 95% of these cases were classified as mild anaemia. Based on the guidelines laid out by the World Health Organization, 5.5% and 43.6% of the surveillance sites were categorized as having severe and moderate epidemic levels of anaemia, respectively. The prevalence of infantile anaemia in Eastern, Central and Western China was 16.67%, 22.25% and 27.44%, respectively. Premature birth, low birth weight, breastfeeding and residence in Western China were significantly associated with higher odds of developing anaemia. Female sex and having mothers with high levels of education and maternal birth age >25 years were associated with lower odds of developing anaemia. In conclusion, we observed significant regional disparities in the prevalence of infantile anaemia in China. Western China had the highest prevalence of infantile anaemia, and rural regions showed a higher prevalence of anaemia than urban regions.     

Matcha Green Tea Alleviates Non-Alcoholic Fatty Liver Disease in High-Fat Diet-Induced Obese Mice by Regulating Lipid Metabolism and Inflammatory Responses

Lately, matcha green tea has gained popularity as a beverage and food additive. It has proved to be effective in preventing obesity and related metabolic syndromes. However, the underlying mechanisms of its control effects against non-alcoholic fatty liver disease (NAFLD) are complicated and remain elusive. In the present study, we performed an in vivo experiment using male C57BL/6 mice fed with a high-fat diet and simultaneously treated with matcha for six weeks. Serum biochemical parameters, histological changes, lipid accumulation, inflammatory cytokines, and relevant indicators were examined. Dietary supplementation of matcha effectively prevented excessive accumulation of visceral and hepatic lipid, elevated blood glucose, dyslipidemia, abnormal liver function, and steatosis hepatitis. RNA sequencing analyses of differentially expressed genes in liver samples indicated that matcha treatment decreased the activity of lipid droplet-associated proteins and increased the activity of cytochrome P450 enzymes, suggesting improved metabolic capacity and liver function. The current study provided evidence for new dietary strategies based on matcha supplementation to ameliorate lipotoxicity-induced obesity and NALFD.     

国产重组人促卵泡激素在辅助生殖技术控制性超促排卵的临床应用

目的评价国产重组人促卵泡激素(recombinant human follicle-stimulating hormone,rhFSH)用于辅助生殖技术(assisted reproductive technology,ART)控制性超促排卵(controlled ovarian hyperstimulation,COH)的有效性及安全性。方法本试验采用多中心、随机、双盲、阳性平行对照、非劣效研究方法,于2017年7月至2019年6月间选取6家生殖医学中心纳入卵巢储备正常的不孕女性进行ART的COH治疗。受试者随机分为试验组(国产rhFSH,n=134)和对照组(进口rhFSH,n=133),研究过程中因各种因素排除受试者共8例,试验组7例,对照组1例,最终依照研究方案完成试验的受试者试验组127例,对照组132例。比较两组受试者COH周期中获得的卵母细胞总数、rhFSH用药情况、卵母细胞受精率、优质胚胎数、临床妊娠率、活产率、新生儿情况及不良反应发生率等指标。结果试验组和对照组在COH周期中获得的卵母细胞总数分别为(13.0±5.8)枚和(12.9±5.7)枚,差异无统计学意义(P>0.05);在82例卵胞质内单精子显微注射(intracytoplasmic sperm injection,ICSI)受试者中,试验组(39例)获得MII卵母细胞数[(9.9±3.9)枚]显著高于对照组(43例)[(7.5±3.0)枚,P=0.003];卵母细胞受精率试验组[63.82%(1048/1642)]显著高于对照组[56.19%(958/1705),P<0.001]。rhFSH用药时间和总量、优质胚胎数、临床妊娠率、早产率、活产率、新生儿异常发生率、新生儿体质量、Apgar评分等两组间差异无统计学意义(P均>0.05);治疗期间卵巢过度刺激综合征(ovarian hyperstimulation syndrome,OHSS)和其他不良反应发生率差异无统计学意义(P均>0.05),且均为进口rhFSH已知的不良反应。结论在卵巢储备正常的不孕女性中使用相同卵巢刺激治疗方案,国产rhFSH有效性及安全性与进口rhFSH相当。