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991.
内皮祖细胞是一群具有游走特性,能进一步增殖分化成为成熟内皮细胞的幼稚内皮细胞.内皮祖细胞参与了出生后缺血组织的血管发生和血管损伤后的修复.内皮祖细胞的发现为血管组织工程种子细胞增添了一个新来源.本文重点介绍成体内皮祖细胞的来源、鉴定、生物学特性、功能以及在血管组织工程中的应用. 相似文献
992.
首发精神分裂症患者精神药物使用调查 总被引:1,自引:0,他引:1
目的 了解首发精神分裂症患者精神药物使用情况。方法 采用回顾性调查研究方法对我院2001年1-6月住院的206例首发精神分裂症患者精神药物使用情况进行调查。结果 单一用药到出院者114例,因用药后疗效不好致换药者24例,合并用药者68例;单一用药频度排列前4位的是氯氮平,氯丙嗪、舒比利,维思通;联用抗胆碱药物者63例。结论 非典型抗精神病药物氯氮平仍是一线抗精神病药物,我院对首发精神分裂症患者精神药物使用基本合理,但应减少联合用药。 相似文献
993.
William Zhao Hsi-en Ho Supinda Bunyavanich 《Annals of allergy, asthma & immunology》2019,122(3):276-282
Objective
To review observational human, murine, and interventional trial studies that have examined the gut microbiome in food allergy, and to provide perspective on future investigations in this field.Data Sources
A review of the published literature was performed with PubMed, and clinical studies catalogued at ClinicalTrials.gov were also reviewed.Study Selections
The most recent relevant studies, seminal works, and topical clinical trials were selected.Results
Gut dysbiosis likely precedes the development of food allergy, and the timing of such dysbiosis is critical. Gut microbiota associated with individual food allergies may be distinct. Murine models support the importance of gut microbiota in shaping immune maturation and tolerance. Gut microbiota may affect food allergy susceptibility by modulating type 2 immunity, influencing immune development and tolerance, regulating basophil populations, and promoting intestinal barrier function. Ongoing and future interventional trials of probiotics, prebiotics, synbiotics, and fecal microbiota transfer will help translate our understanding of the gut microbiome in food allergy to clinical practice. Future work in this area will include deepening of current research foci, as well as expansion of efforts to include the virome, mycobiome, and interactions between the microbiome, host, and environment. Robust and consistent study designs, multidimensional profiling, and systems biology approaches will enable this future work.Conclusion
By advancing research on the microbiome in food allergy, we can further our understanding of food allergy and derive new approaches for its prevention and therapy. 相似文献994.
995.
构建7q32区域鼻咽癌和正常鼻咽上皮细胞部分基因的表达图谱 总被引:7,自引:2,他引:7
目的构建7q32区域鼻咽癌细胞和组织及原代培养人正常鼻咽上皮细胞的部分基因表达图谱。方法通过差异RT-PCR和Northern杂交的方法检测定位于7q32区域的20个EST在鼻咽癌细胞和鼻咽癌组织及原代培养人正常鼻咽上皮细胞mRNA的表达水平。结果8个EST在鼻咽癌细胞HNE1和原代培养人正常鼻咽上皮细胞中表达量较一致,7个EST在两种细胞中均无表达,3个EST(W72688、H19830、AA130630)在鼻咽癌细胞株中表达上调,而2个EST(AA070437、H90882)在原代培养人鼻咽上皮细胞中表达上调。在13例鼻咽癌活检组织中30.7%(4/13)的AA070437表达下调,77%(10/13)的W72688和77%(10/13)的H19830表达上升。结论构建了7q32区域鼻咽癌细胞和组织及原代培养人正常鼻咽上皮细胞部分基因表达图谱,并初步认为A070437的表达下调和W72688、H19830的过表达与鼻咽癌的发生有关。 相似文献
996.
益尔力口服液主治强力疲劳、气血虚损引起的肢体疲倦、精神不振、举动乏力。用葸酮法研究表明,其对肝糖原合成有明显促进作用,可作为扶正固本指标之一。 相似文献
997.
对17例慢性牙周炎患者牙龈组织基膜进行电镜观察发现,随着病情加重基膜出现增生,断裂,分离及多层化等不同程度的改变,与基膜关系密切的微原纤维亦称耐酸纤维,同时严重受损并形成颗粒样物,沉集在基膜附近,在基膜断裂之穴口中可见有胶原纤维嵌入。这样既破坏了基膜的防御屏障,也阻碍了牙周其它正常组织的修复,从而进一步加深了牙周病的发展。 相似文献
998.
Mice with the scid mutation have a defect in the V(D)J recombinase. In order to
determine whether the SCID product is normally present in mature B cells that do not
have the recombinase activity, scid pre-B cells were fused with myeloma cells. It was
found that in the hybrid cells, a rearrangement test gene was correctly joined
immediately after fusion. The same test gene was aberrantly rearranged in the scid pre-B
cells. Stable hybrids between the scid pre-B and the myeloma cells had lost the
expression of RAG-1 and RAG-2 genes, supporting the previous finding of an inhibitor
of rearrangement in myeloma cells that acts shortly after fusion. Thus, mature B cells
apparently contain the SCID product, the wild type SCID function is not competitively
interfered with by products present in scid pre-B cells, and the SCID product seems not
to be a target for the recombinase inhibitor. 相似文献
999.
目的:研究信号蛋白ILK在IL-1β诱导的肾小管上皮细胞-肌成纤维细胞转分化(TEMT)中的表达变化以及大黄素是否是通过抑制ILK的表达而影响IL-1β诱导的肾小管上皮细胞-肌成纤维细胞转分化.方法:以体外培养的正常大鼠肾小管上皮细胞株(NRK52E)为研究对象,分为空白对照组、大黄素对照组、IL-1β诱导组、IL-1β加大黄素组.在倒置相差显微镜下观察细胞形态变化;免疫双标法检测a-平滑肌肌动蛋白(a-SMA)和E-钙黏连素(E-cadherin)的表达;免疫单染检测ILK的表达;ELISA法测定培养细胞分泌的纤维连接蛋白(FN)含量.结果:IL-1β诱导细胞转变为明显类似成纤维细胞形态,增加a-SMA的表达[(65.5±1.7)vs(140.4±3.0),P<0.05],减少E-cadherin的表达[(82.5±1.0)vs(36.0±2.8),P<0.05),促进ILK的表达[(36.1±3.1)vs(82.4±1.2),P<0.05],促进FN的合成[(54.6±3.1)mg/Lvs(124.8±3.2)mg/L,P<0.05],加入大黄素后上述变化受到明显抑制.结论:在IL-1β诱导的TEMT中ILK的表达是明显上调的,大黄素可能通过下调ILK的表达而抑制IL-1β诱导的TEMT. 相似文献
1000.
Yen Yi Chou Te Yu Lin Jung Chung Lin Ning Chi Wang Ming Yieh Peng Feng Yee Chang 《Journal of microbiology, immunology, and infection》2008,41(2):124-129
BACKGROUND AND PURPOSE: Vancomycin-resistant enterococci (VRE) have emerged as important nosocomial pathogens. This study was conducted to clarify the clinical features and outcome of patients with vancomycin-resistant enterococcal bacteremia. METHODS: Patients with vancomycin-resistant enterococcal bacteremia treated at a medical center in northern Taiwan between November 1998 and July 2006 were reviewed. Clinical and bacteriological characteristics of Enterococcus faecium and Enterococcus faecalis were compared. RESULTS: Twelve patients (6 males and 6 females) were included for analyses. The mean age was 69.3 years (range, 40 to 86 years), and 8 cases (66.7%) were older than 65 years. All patients had underlying disease. Two patients received total hip replacement before development of VRE bacteremia. Twelve patients had prior exposure to broad-spectrum antimicrobial therapy. Ten patients had prior intensive care unit stay and prior mechanical ventilation before VRE bacteremia. All of the patients (n = 12) had an intravascular catheter in place. Bacteremia was caused by E. faecalis in 4 patients and by E. faecium in eight. The portals of entry included urinary tract (8.3%), skin, soft tissue and bone (41.7%) and unknown sources (50.0%). E. faecium showed a higher rate of resistance to ampicillin and teicoplanin than E. faecalis (87.5% vs 0.0%, p=0.01). The 60-day mortality rate was higher in patients with E. faecium bacteremia than E. faecalis bacteremia (62.5% vs 0.0%), although statistical significance was not obtained (p=0.08). CONCLUSIONS: VRE bacteremia may have an impact on the mortality and morbidity of hospitalized patients. Patients with bacteremia caused by vancomycin-resistant E. faecium had a grave prognosis, especially immunosuppressed patients. The prudent use of antibiotics and strict enforcement of infection control may prevent further emergence and spread of VRE. 相似文献