芪丹颗粒剂治疗肺间质纤维化105例临床研究

目的:观察芪丹颗粒剂对肺间质纤维化患者的临床疗效.方法:选择105例肺间质纤维化患者作为治疗组,给予芪丹颗粒剂,对照组60例,给予强的松0.5mg/kg,两组疗程均为3～6个月,每1～3个月随诊1次.观察两组患者治疗后的症状、体征、肺部高分辨率CT(HRCT)及肺功能变化.结果:治疗6个月后,治疗组症状、体征改善率优于对照组(P＜0.05或P＜0.01);治疗组治疗3个月和6个月后,肺HRCT和肺功能改善率优于对照组(P＜0.05或P＜0.01).结论:芪丹颗粒剂可以不同程度地改善肺间质纤维化患者症状和体征,使患者肺功能停止恶化,且用药期间未见任何副作用,耐受性良好.     

波依定与洛汀新治疗不同中医证型高血压疗效比较

目的:观察波依定与洛汀新对不同中医证型高血压的疗效是否具有中草药的某些特征,能否按中医辨证选择抗高血压药.方法:按照WHO的标准明确高血压诊断与分级,根据<中药新药临床研究指导原则>分为4型.216例患者随机分为两组,分别给予波依定与洛汀新治疗,疗程4周.分析对总体血压和不同证型血压的影响,以及对不同症状的疗效有无差异.结果:两种药物降低患者总体血压的幅度基本相同;但分层研究,对4种中医证型患者的血压的降低程度明显不同,洛汀新对肝火亢盛型血压降低幅度更明显,波依定对痰湿壅盛型比其它三型降压更好;对阴虚阳亢型和阴阳两虚型两组之间差异无显著性.对各种证型症状的改善作用也显示同样的结果.结论:抗高血压药对不同中医证型高血压的疗效不同,表明西药也同样具有中草药的某些特性,可以根据中医辨证选择抗高血压药.     

HPLC法测定紫茉莉根中葫芦巴碱的含量

目的测定紫茉莉根中葫芦巴碱的含量.方法采用 HPLC法,色谱柱:Inertsil NH2Columns(250× 4.6 mm,5 μ m,迪马公司);流动相:乙腈-水(80:20);流速:0.8 mL· min-1;检测波长:265 nm;柱温:30 ℃.结果葫芦巴碱在 0.1872～ 0.9360 μ g之间与峰面积呈良好线性关系,r=0.9996;葫芦巴碱的平均回收率为 99.6 %,RSD=1.76%(n=6).结论该方法分离效果好,简便、准确,可用于紫茉莉根的初步质量控制.     

根据三焦理论探讨头和躯干部位俞穴的规律

人体的经穴有365个,其中特定穴120个.历代针灸医书中论述特定穴者占绝大多数,而这些特定穴大多分布在四肢部,躯干部的特定穴只有俞募穴等较少的穴位.从历史沿革上来看,经络首先明确的是四肢部的走行,头与躯干的经脉走行历代均有出入,因而头与躯干部的经穴历代记载也有所不同.且古代医家对头与躯干的许多经穴有很多禁忌,也限制了人们对头与躯干部穴位的充分认识.     

田螺治疗肝硬化腹水40例

自1996年以来，我们用田螺治疗部分肝硬化腹水病人，疗效确切，现报告如下。     

指压攒竹穴治疗呃逆

笔者自2000年以来运用指压攒竹穴治疗呃逆17例．经临床观察疗效满意。现介绍如下。     

慢性阻塞性肺疾病的护理

慢性阻塞性肺疾病（简称慢阻肺，COPD）是一种以不完全可逆的气流受阻为特征的肺部慢性疾病，气流受阻不完全可逆，呈进行性发展，与肺部对有害气体或有害颗粒的异常炎症反应有关。现将护理方法简述如下。     

中医药院校公共事业管理专业人才培养方案及课程体系科学化研究

为优化专业培养方案,使课程设置更加符合培养目标,采用文献分析、专家访谈、召开毕业生座谈会等方法,对中医药院校公共事业管理专业人才培养的总体思路、基本原则、培养目标和课程体系的科学化进行了研究,制定出医药经营管理、医疗保险、医院管理3个专业方向的本科学分制改革培养计划,并针对教学实践中存在的主要问题提出了相应的建议,为中医药院校公共事业管理专业的建设与发展提供参考.     

RAS mutation is associated with hyperdiploidy and parental characteristics in pediatric acute lymphoblastic leukemia.

We explored the relationship of RAS gene mutations with epidemiologic and cytogenetic factors in a case series of children with leukemia. Diagnostic bone marrow samples from 191 incident leukemia cases from the Northern California Childhood Leukemia Study were typed for NRAS and KRAS codon 12 and 13 mutations. A total of 38 cases (20%) harbored RAS mutations. Among the 142 B-cell acute lymphoblastic leukemia (ALL) cases, RAS mutations were more common among Hispanic children (P=0.11) or children born to mothers <30 years (P=0.007). Those with hyperdiploidy at diagnosis (>50 chromosomes) had the highest rates of RAS mutation (P=0.02). A multivariable model confirmed the significant associations between RAS mutation and both maternal age and hyperdiploidy. Interestingly, smoking of the father in the 3 months prior to pregnancy was reported less frequently among hyperdiploid leukemia patients than among those without hyperdiploidy (P=0.02). The data suggest that RAS and high hyperdiploidy may be cooperative genetic events to produce the leukemia subtype; and furthermore, that maternal age and paternal preconception smoking or other factors associated with these parameters are critical in the etiology of subtypes of childhood leukemia.     

Green tea extract modulates actin remodeling via Rho activity in an in vitro multistep carcinogenic model.

Alteration of actin polymerization and loss of actin filaments is a marker of cellular dedifferentiation and early malignant transformation. To study this phenomenon, an in vitro human urothelial model consisting of two cell lines, HUC-PC and MC-T11, were incorporated into the study design. These two cell lines have different malignant transformation potential. The effect of green tea extract (GTE), a potential anticancer agent, on actin remodeling was investigated. Upon exposure to the carcinogen 4-aminobiphenyl (4-ABP), the untransformed HUC-PC undergoes malignant transformation whereas the transformed MC-T11 progresses from noninvasive to invasive tumor. GTE induces actin polymerization in MC-T11 cells in a dose-responsive manner, but this effect is less obvious in the untransformed, more differentiated HUC-PC cells, which natively have higher actin polymerization status. In contrast, GTE antagonizes carcinogen 4-ABP induced actin depolymerization and stress fiber disruption in HUC-PC cells. In MC-T11 cells, GTE inhibits 4-ABP induced motility by increasing cell adhesion and focal adhesion complex formation. The effect of GTE on actin remodeling seems to be mediated by the stimulation of small GTP-binding protein Rho activity, because C3 exoenzyme, a specific inhibitor for Rho, blocks GTE-mediated Rho activation and stress fiber formation in MC-T11 cells. This study shows that GTE exerts an effect on cytoskeletal actin remodeling and provides further support for the use of GTE as a chemopreventive agent.