全文获取类型
收费全文 | 54386篇 |
免费 | 2599篇 |
国内免费 | 4463篇 |
专业分类
耳鼻咽喉 | 508篇 |
儿科学 | 718篇 |
妇产科学 | 1015篇 |
基础医学 | 8967篇 |
口腔科学 | 770篇 |
临床医学 | 3386篇 |
内科学 | 10355篇 |
皮肤病学 | 490篇 |
神经病学 | 3609篇 |
特种医学 | 1031篇 |
外国民族医学 | 8篇 |
外科学 | 5266篇 |
综合类 | 6350篇 |
现状与发展 | 74篇 |
一般理论 | 20篇 |
预防医学 | 2606篇 |
眼科学 | 2193篇 |
药学 | 6137篇 |
8篇 | |
中国医学 | 1356篇 |
肿瘤学 | 6581篇 |
出版年
2024年 | 133篇 |
2023年 | 552篇 |
2022年 | 392篇 |
2021年 | 295篇 |
2020年 | 220篇 |
2019年 | 183篇 |
2018年 | 183篇 |
2017年 | 93篇 |
2016年 | 155篇 |
2015年 | 261篇 |
2014年 | 633篇 |
2013年 | 292篇 |
2012年 | 9783篇 |
2011年 | 10757篇 |
2010年 | 1913篇 |
2009年 | 735篇 |
2008年 | 5598篇 |
2007年 | 5682篇 |
2006年 | 4990篇 |
2005年 | 4501篇 |
2004年 | 3594篇 |
2003年 | 2995篇 |
2002年 | 2417篇 |
2001年 | 1260篇 |
2000年 | 1716篇 |
1999年 | 916篇 |
1998年 | 415篇 |
1997年 | 113篇 |
1996年 | 66篇 |
1995年 | 78篇 |
1994年 | 44篇 |
1993年 | 29篇 |
1992年 | 13篇 |
1991年 | 16篇 |
1990年 | 12篇 |
1989年 | 48篇 |
1988年 | 47篇 |
1987年 | 65篇 |
1986年 | 21篇 |
1985年 | 44篇 |
1984年 | 48篇 |
1983年 | 45篇 |
1982年 | 21篇 |
1981年 | 24篇 |
1980年 | 25篇 |
1979年 | 18篇 |
1978年 | 1篇 |
1975年 | 3篇 |
1964年 | 2篇 |
1959年 | 1篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
11.
BACKGROUND: It is known that intravenous anesthetic etomidate fat emulsion has cerebral protection. Now many scholars focus on the research of its cerebral protection from molecular biology, but the mechanism of cerebral protection is still fully unclear.
OBJECTIVE: To observe the influence of etomidate fat emulsion on the [Ca2+]i in hippocampal neurons during the transient cerebral ischemia injury in rats.
DESIGN: Randomized controlled observation.
SETTING: Weifang Medical College.
MATERIALS: This study was carried out in the functional laboratory of Weifang Medical College between October 2005 and March 2006. Twenty-four male healthy Wistar rats, aged 3 to 4 months, were involved. Etomidate fat emulsion was provided by the limited company of En-hua Medical Bloc in Jiangsu Province (code of H20020511) and the other agents and materials were provided by Laboratory Center of Weifang Medical College.
METHODS: The 24 Wistar rats were randomized into 3 groups: sham-operation group, model group and etomidate preconditioning group, with 8 rats in each. Rat models of transient cerebral ischemia injury were made by the ligation of bilateral carotid arteries combined with descending blood pressure in the latter two groups. Before ischemia (ligation of bilateral common carotid artery), rats in the etomidate preconditioning group were intraperitoneally injected with 12 mg/kg etomidate fat emulsion and then persistently intraperitoneally injected with etomidate fat emulsion at 1.0 mg/kg per minute. Rats in the model group were not administrated. Rats in the sham-operation group were only performed bilateral common carotid artery isolation. When rats were modeled, their brain tissues were quickly taken out and detected.
MAIN OUTCOME MEASURES: Change of the fluorescence pixel value of the [Ca2+]i in each group by the laser scanning confocal microscope.
RESULTS: Twenty-four rats were involved in the final analysis. Fluorescence pixel value in the sham-operation group was in the low level. Fluorescence pixel value in the model group was significantly higher than that in the sham-operation group (P < 0.01). Fluorescence pixel value in the etomidate preconditioning group was significantly lower than that in the model group (P < 0.01).
CONCLUSION: The protection of etomidate fat emulsion to the transient cerebral ischemic injury in rats is associated with the inhibition to the increase of [Ca2+]i to some extent. 相似文献
12.
Zhang Ying-lin张应霖 Liao Da-mei廖大美 Wei Yong-gui魏永贵and Bai Guo-rong白国荣Luzhou Medical College Sichuan 《中华医学杂志(英文版)》1987,100(1):56-57
In 1980, 267 patients with related symp-
toms were examined by tomography in our hos-
pital. Among them the styloid process (SP) of
128 cases were 30 mm or more in length. Pha-
ryngeal palpation was performed in 98. The SPs
of 61 patients were palpable and tender. Diagno-
sis was based on the related symptoms, tomogra-
phy, positive pharyngeal palpation and SP tender-
ness. Tomography showed that the longest SP
was 75 mm, while the longest one with symptoms
was 65 mm. The medial angulations of the SPs
were from 100 t0 27° and the anterior angulations
from 300 t0 50°. 相似文献
13.
Xian ZH Zhang SH Cong WM Wu WQ Wu MC 《第二军医大学学报》2005,26(11):1320-1320
BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most prevalent fatal cancers in the world. Despite advances in early diagnosis and improvements in surgical techniques, the survival of patients with HCC even after resection is poor because of the high incidence of recurrences. Therefore, the identification of prognostic factors may be helpful in the development of new treatment protocols. AIMS: To investigate HER-2/neu status in HCC by immunohistochemistry (IHC) and fluorescence in situ hybridisation (FISH), and to explore the possibility of using trastuzumab in the treatment of HCC. METH ODS: Eight hundred and sixty eight surgical samples from patients with primary HCC were examined for their HER-2/neu status. IHC for HER-2/neu was performed with the HercepTest kit; FISH analysis was performed with the PathVysion HER-2 DNA probe kit. The correlations between HER-2/neu overexpression and clinicopathological characteristics were analysed statistically. RESULTS: HER-2/neu overexpression was detected in 21 (2.42%) of the 868 primary HCCs. Only one specimen showed HER-2/neu gene amplification by FISH. No significant associations were found between HER-2/neu overexpression and the clinicopathological parameters. CONCLUSIONS: There is a low frequency of HER-2/neu overexpression/amplification in HCC. There appears to be no role for HER-2/neu as a prognostic marker and no benefit of anti-HER-2/neu trastuzumab treatment in patients with HCC. 相似文献
14.
Sun Ren-yu孙仁宇 Yan Yi-zhao严仪昭 Zhang Hong张宏and Li Chang-cheng李长城Institute cf Basic Metiical Sciences Chinee Academy of Medical Sciences Beijing 《中华医学杂志(英文版)》1989,102(1):1-6
Acute pulmonary hypertension was caused by
inhalation of 5% 02 in rats. Pulmonary vascujar re-
sistance (PVR) increased, but heart rate (HR), cardiac
output (CO) and carotid arterial pressure (CAP) were
not obviously changed. After an intravenous admini-
stration of Radix Angelicae sinensis, the acute
pulmonary hypertension induced by inhalation of 5%
O2 could be attenuated, but this effect disappeared if
propranolol was given before Radix Angelicae sinensis.
In chronic experiments, the same results were
obtained, but the protective effect of Radix Angelicae
sinensis on heart function was not influenced by
propranolol. It is suggested that Radix Angelicae
sinensis rmght play a role by stimulating the
βz-receptor in the prevention of acute and chronic
hypoxic pulmonary hypertension. However, prevention
of hypertrophy of the right ventricle and enhancement
of heart function in chronic hypoxic rats might not be
attributed to the β1 receptor in the heart. 相似文献
15.
INTRODUCTION Neuroglobin (NGB) is a recently discovered member of the vertebrate globin family [1], predominantly expressed in various brain regions of human and vertebrate. The expression of NGB was increased in case of ischemia, which may play a role in… 相似文献
16.
Qingfeng Sheng Yurong Shi Qiang Li Jihui Hao Ruifang Niu Xiyin Wei Yi Yang Lin Zhang 《中国肿瘤临床(英文版)》2006,3(6):442-446
A poptosis, an evolutionarily conserved form of cell suicide, oc- curs in two physiological stages: commitment and execution.[1] It has been found that several Bcl-2 family proteins are located in the outer mitochondrial membrane, where they control relea… 相似文献
17.
全雄激素阻断是前列腺癌(PCa)治疗的重要手段。虽然已发现一些蛋白分子涉及雄激素的调节[1] ,但其分子机理尚不清楚。我们采用分子生物学方法检测人PCa全雄激素阻断前后Bcl 2和Bcl XL 蛋白的表达,探讨PCa发生发展的分子机理。材料与方法 4 2例局限性PCa患者。全雄激素阻断治疗采用抑那通或诺雷德皮下注射加口服Flutamide 3个月,然后患者接受PCa根治术。PCa标本分别经穿刺活检和根治术标本取得,10 %福尔马林固定后石蜡包埋,病理证实。Bcl 2和Bcl XL 蛋白单克隆抗体(1/ 2 0 0 )和试剂盒购于SantaCruzInc。显微镜下,细胞着色棕黄… 相似文献
18.
WANG MaoRong LE MeiZhao XU JiaZhang HE ChangLun 《World journal of gastroenterology : WJG》1997,(4)
Establishmentandapplicationofexperimentalmodelofhumanfetalhepatocytes:protectiveeffectsofsilybinandpolyporusumbelaluspolysac... 相似文献
19.
结核病的现代药物治疗 总被引:13,自引:0,他引:13
面对结核病在便于范围内卷土重来,最重要的应对策略是在提高病人治疗依从性的基础上推广有效的化疗方案。 相似文献
20.
Zhang Mei-ying张美英and Zhang Xiao-lou张晓楼Depart''ment of Ophthalmol ogy Tongren Hospital Beijing 《中华医学杂志(英文版)》1987,100(8):677-678
A perusal of the medical literature re-
vealod only one case of giant nonmetallic in
traocular foreign body, 15x11x7 mm, removed
in China However, no mention was made of
the operative result of the wounded eye in the
report. Usually after removal of intraocular
foriegn bodies, especially the giant ones, the
eyeball becomes inevitably atrophied, thus it
has to be enucleated soon after operation.
We removed a giant intraocular metallic
foreign body, measuring 18.1x9x1.5 mm and
weighing 0.24 g, from the left eye of a patient
at our clinic. Follow-up l year after operation
found that the eyeball of the affected eye was
good in appearance with preservation of partial
vision. 相似文献