八珍益母胶囊辅助治疗子宫腺肌病临床研究

目的：观察八珍益母胶囊辅助治疗子宫腺肌病的临床疗效。方法：选择80例气滞血瘀型子宫腺肌病患者,按随机数字表法分为对照组与观察组各40例。对照组采用孕三烯酮、双氯芬酸钠治疗,观察组在对照组的基础上联合八珍益母胶囊辅助治疗。比较2组治疗前后子宫体积、痛经评分、中医证候积分、疼痛指标[血清前列腺素E₂(PGE₂)、5-羟色胺(5-HT)]水平及临床疗效。结果：观察组总有效率为90.00%,显著高于对照组72.50%,2组比较,差异有统计学意义(P<0.05)。治疗前,2组小腹胀痛、块下痛减、经行不畅、烦躁易怒、胸闷不舒、乳房胀痛、经血色紫有块、经血量少等证候评分及总分比较,差异均无统计学意义(P>0.05);治疗后,2组上述各项证候评分及总分均较治疗前显著降低(P<0.05),且观察组各项评分及总分均低于对照组(P<0.05)。治疗前,2组子宫体积、痛经评分比较,差异无统计学意义(P>0.05);治疗后,2组子宫体积、痛经评分均较治疗前显著降低(P<0.05),且观察组上述2项指标均低于对照组(P<0.05...     

ASO Visual Abstract: Development and Validation of Web-Based Nomograms for Predicting Cause-Specific Mortality in Surgically Resected Nonmetastatic Invasive Breast Cancer: A Population-Based Study

Annals of Surgical Oncology -     

Endogenous estrogen status, but not genistein supplementation, modulates 7,12-dimethylbenz[a]anthracene-induced mutation in the liver cII gene of transgenic big blue rats

A growing number of studies suggest that isoflavones found in soybeans have estrogenic activity and may safely alleviate the symptoms of menopause. One of these isoflavones, genistein, is commonly used by postmenopausal women as an alternative to hormone replacement therapy. Although sex hormones have been implicated as an important risk factor for the development of hepatocellular carcinoma, there are limited data on the potential effects of the estrogens, including phytoestrogens, on chemical mutagenesis in liver. Because of the association between mutation induction and the carcinogenesis process, we investigated whether endogenous estrogen and supplemental genistein affect 7,12-dimethylbenz[a]anthracene (DMBA)-induced mutagenesis in rat liver. Intact and ovariectomized female Big Blue rats were treated with 80 mg DMBA/kg body weight. Some of the rats also received a supplement of 1,000 ppm genistein. Sixteen weeks after the carcinogen treatment, the rats were sacrificed, their livers were removed, and mutant frequencies (MFs) and types of mutations were determined in the liver cII gene. DMBA significantly increased the MFs in liver for both the intact and ovariectomized rats. While there was no significant difference in MF between the ovariectomized and intact control animals, the mutation induction by DMBA in the ovariectomized groups was significantly higher than that in the intact groups. Dietary genistein did not alter these responses. Molecular analysis of the mutants showed that DMBA induced chemical-specific types of mutations in the liver cII gene. These results suggest that endogenous ovarian hormones have an inhibitory effect on liver mutagenesis by DMBA, whereas dietary genistein does not modulate spontaneous or DMBA-induced mutagenesis in either intact or ovariectomized rats.     

喉癌下咽癌TGFβ1、p16表达的意义

目的 :通过对喉癌、下咽癌组织中转化生长因子 β1(TGFβ1)及 p16蛋白的定位、半定量研究 ,探讨其在喉癌、下咽癌组织中的表达与意义。方法 :采用SABC免疫组化法研究TGFβ1与 p16蛋白的表达 ,并对表达结果进行统计分析。结果 :TGFβ1位于胞浆 /胞膜 ,p16蛋白位于胞浆 /胞核。TGFβ1强表达率为61% ,p16蛋白强表达率为 66%。高分化与中、低分化肿瘤的TGFβ1表达均有统计学差异 (P <0 .0 5) ;高分化与低分化肿瘤的 p16蛋白表达具统计学差异 (P <0 .0 5)。TGFβ1和 p16蛋白之间存在正相关系 (P <0 .0 5)。TGFβ1和 p16蛋白的表达与患者年龄、性别、肿瘤生长部位、病程、临床分期无明显相关。 结论 :TGFβ1与 p16蛋白在喉癌、下咽癌中存在缺失表达 ,在高分化肿瘤中有更高的表达 ,在细胞周期中具有共同的作用。     

视网膜母细胞瘤中Fas和bcl-2的表达及意义

目的　探讨Fas及bcl 2在视网膜母细胞瘤的表达及意义。方法　用免疫组织化学SP方法检测了 45例视网膜母细胞瘤及 12例正常视网膜组织中Fas及bcl 2蛋白的表达 ,并进行比较。结果　Fas在视网膜母细胞瘤组织及正常视网膜组织的表达分别为 0 .2 5 5± 0 .441,0 .0 83± 0 .2 89,两者比较差异无显著性 (P =0 .114 8) ,均呈低表达 ;bcl 2在视网膜母细胞瘤中的表达为2 .70 2± 1.0 82 ,与正常视网膜组织中 0 .16 7± 0 .389相比差异具非常显著性 (P <0 .0 0 0 1)。结论　Fas在视网膜母细胞瘤及正常视网膜中均呈低表达 ;而bcl 2在视网膜母细胞瘤中呈明显高表达 ,其可明显抑制凋亡的发生 ,与肿瘤的发展关系密切。     

CT scanning and arthroscopic evaluation of patellofemoral malalignment

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染色体变异与男性不育

目的 探讨染色体异常与男性不育的关系。方法 对565例男性不育患者进行染色体分析。结果 发现染色体异常69例,异常率为12.21%。其中性染色体异常48例,占异常核型 69.75%;性反转综合征1例,占异常核型1.45%;常染色体异常20例,占异常核型28.98%。结论 染色体异常是造成男性不育的重要遗传因素。提示对精液检查异常者或男性性征发育不良者进行染色体检查,将有助于不育病因的诊断。     

多动行为偏异儿童血5-羟色胺测定及其意义

目的　探讨心理卫生偏异 (简称行为异常 )多动行为偏异儿童 (简称多动 )与正常儿童血 5 -羟色胺 (5 -HT)含量差别。方法　用Achenbach儿童行为量表筛查并根据因子分分类对 30例行为异常儿童进行血 5 -HT含量测定 ,与 30例正常儿童对照组比较。结果　行为异常组血 5 -HT含量与正常组比较 ,无显著差异。而多动组与正常组比较 ,有显著差异 (P <0 .0 5 )。内向型因子组与正常组比较 ,有显著差异 (P <0 .0 5 )。结论　多动行为偏异儿童血 5 -HT含量明显降低 ,心理卫生偏异内向型组血 5 -HT含量明显升高。     

乳癌保留乳房手术的探讨

①目的 探讨乳癌保留乳房手术的可行性。②方法 将９０例Ⅰ,Ⅱ期乳癌病人随机分为两组,保留乳房手术组４２例,采用乳腺区段切除加腋窝淋巴结清扫术;改良根治术组４８例,采用乳腺全切加腋窝淋巴结清扫术,术后两组均行放疗、化疗和内分泌治疗。比较两组治疗效果及并发症发生情况。③结果 乳癌保留乳房手术组３年生存率为９５．２％,５年生存率为９１．７％,发生并发症４例,改良根治术组３年生存率为９５．８％,５年生存率     

透析液简易集中供液装置的设计

本文介绍了利用循环冲击的配液原理设计的一套集中配制、输送透析液一体机。它能提高透析配液效率,提高配液质量,减少透析液在配制、存储、运输过程中细菌污染的机会和消耗的大量人力。同时,这套装置还可做消毒机对供水系统进行清洗、消毒,消除致热原、内毒素的污染。