全文获取类型
收费全文 | 2142篇 |
免费 | 83篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 9篇 |
儿科学 | 20篇 |
妇产科学 | 9篇 |
基础医学 | 230篇 |
口腔科学 | 37篇 |
临床医学 | 176篇 |
内科学 | 599篇 |
皮肤病学 | 23篇 |
神经病学 | 172篇 |
特种医学 | 149篇 |
外科学 | 340篇 |
综合类 | 10篇 |
预防医学 | 60篇 |
眼科学 | 87篇 |
药学 | 166篇 |
中国医学 | 8篇 |
肿瘤学 | 135篇 |
出版年
2023年 | 8篇 |
2022年 | 28篇 |
2021年 | 43篇 |
2020年 | 34篇 |
2019年 | 28篇 |
2018年 | 37篇 |
2017年 | 21篇 |
2016年 | 38篇 |
2015年 | 38篇 |
2014年 | 42篇 |
2013年 | 54篇 |
2012年 | 91篇 |
2011年 | 117篇 |
2010年 | 65篇 |
2009年 | 50篇 |
2008年 | 99篇 |
2007年 | 111篇 |
2006年 | 123篇 |
2005年 | 122篇 |
2004年 | 112篇 |
2003年 | 84篇 |
2002年 | 90篇 |
2001年 | 97篇 |
2000年 | 70篇 |
1999年 | 45篇 |
1998年 | 12篇 |
1997年 | 15篇 |
1996年 | 21篇 |
1995年 | 14篇 |
1994年 | 8篇 |
1993年 | 13篇 |
1992年 | 42篇 |
1991年 | 44篇 |
1990年 | 46篇 |
1989年 | 42篇 |
1988年 | 41篇 |
1987年 | 29篇 |
1986年 | 38篇 |
1985年 | 32篇 |
1984年 | 25篇 |
1983年 | 19篇 |
1982年 | 8篇 |
1981年 | 10篇 |
1980年 | 8篇 |
1979年 | 14篇 |
1977年 | 14篇 |
1975年 | 10篇 |
1972年 | 8篇 |
1970年 | 8篇 |
1966年 | 10篇 |
排序方式: 共有2230条查询结果,搜索用时 23 毫秒
51.
Nishioka T Mitani H Uehata A Hikita H Nagai T Katsushika S Takase B Isojima K Ohsuzu F Kurita A Ohtomi S Siegel RJ 《American heart journal》2003,145(1):162-168
Background The utility of exercise echocardiography for evaluating remote ischemia due to noninfarct-related artery (n-IRA) lesions in patients with prior myocardial infarction has not been established.Methods Quantitative coronary angiography and treadmill exercise echocardiography were performed within 2 weeks in 115 patients with prior myocardial infarction (>6 weeks) and 224 patients without myocardial infarction. Coronary lumen diameter stenosis ≥50% (by angiography) and the lack of a hyperdynamic response on exercise echocardiography were considered significant. Myocardial infarction size was defined as the number of myocardial segments with severe hypokinesis, akinesis, or dyskinesis on echocardiography at rest.Results For detection of n-IRA lesions in patients with prior myocardial infarction, the sensitivity of exercise echocardiography was similar (78% vs 79%, P = not significant), however, the specificity was significantly lower (77% vs 91%, P < .01) than for detection of significant stenoses in patients without prior myocardial infarction. Angiographic percent-diameter stenosis, presence of collateral vessel, achieved exercise level, and presence of peri-infarct ischemia did not affect the specificity of exercise echocardiography. However, the specificity of exercise echocardiography was significantly lower (69% vs 84%, P < .05) in patients with echocardiographically large infarction (infarction size ≥2) than in patients with small infarction (infarction size <2).Conclusion In patients with prior myocardial infarction, exercise echocardiography showed low specificity for detection of noninfarct-related artery lesions, especially in patients with echocardiographically large myocardial infarction. These characteristics of treadmill exercise echocardiography should be considered when this technique is applied for patients with healed myocardial infarction. (Am Heart J 2003;145:162-8.) 相似文献
52.
BACKGROUND/AIMS: We investigated the relationship between percutaneous papillary balloon dilatation (PPBD) and hyperamylasemia after PPBD. METHODOLOGY: We studied the rate of pancreatitis and asymptomatic hyperamylasemia after PPBD for choledocholithiasis in 64 symptomatic patients. Pancreatitis was defined as epigastric pain combined with at least a 3-fold rise in serum amylase at 24 hours after PPBD. Asymptomatic hyperamylasemia was defined as a rise in serum amylase (normal range, 50 to 160 IU/L) without epigastric pain. RESULTS: The stones were successfully pushed out into the duodenum in all patients. Three patients developed post-PPBD pancreatitis, graded moderate in one and mild in two. Serum amylase values were elevated over the normal upper limit in 21 patients, 33%, over 3-fold in 10, 16% over 1000 IU/L in 6, 9%. Asymptomatic hyperamylasemia was observed in 18 patients. The amylase value after PPBD was elevated to more than 160 IU/L in 44% (17/39) of patients 80 years old or under vs. 16% (4/25) of patients older than 80 and in 23% (10/44) of patients with intrahepatic bile duct dilatation on admission vs. 55% (11/20) of patients without it, with a significant difference, respectively (p<0.05). The amylase value after PPBD was elevated to more than 1000 IU/L in 15% (6/39) of patients 80 years old or under vs. 0% (0/25) of patients older than 80 and in 29% (4/14) of patients with bile duct stones having a horizontal diameter of 8mm or smaller and 4% (2/50) of patients with stones larger than 8mm (p < 0.05 and p<0.01, respectively). CONCLUSIONS: We believe that postoperative continuous decompression of the bile duct by PPBD is reliable and that it contributed to the prevention of severe pancreatitis. We conclude that PPBD can be performed more safely in symptomatic patients older than 80 with choledocholithiasis with intrahepatic bile duct dilatation at the time of admission. 相似文献
53.
54.
Kawai T Nishikomori R Izawa K Murata Y Tanaka N Sakai H Saito M Yasumi T Takaoka Y Nakahata T Mizukami T Nunoi H Kiyohara Y Yoden A Murata T Sasaki S Ito E Akutagawa H Kawai T Imai C Okada S Kobayashi M Heike T 《Blood》2012,119(23):5458-5466
Somatic mosaicism has been described in several primary immunodeficiency diseases and causes modified phenotypes in affected patients. X-linked anhidrotic ectodermal dysplasia with immunodeficiency (XL-EDA-ID) is caused by hypomorphic mutations in the NF-κB essential modulator (NEMO) gene and manifests clinically in various ways. We have previously reported a case of XL-EDA-ID with somatic mosaicism caused by a duplication mutation of the NEMO gene, but the frequency of somatic mosaicism of NEMO and its clinical impact on XL-EDA-ID is not fully understood. In this study, somatic mosaicism of NEMO was evaluated in XL-EDA-ID patients in Japan. Cells expressing wild-type NEMO, most of which were derived from the T-cell lineage, were detected in 9 of 10 XL-EDA-ID patients. These data indicate that the frequency of somatic mosaicism of NEMO is high in XL-ED-ID patients and that the presence of somatic mosaicism of NEMO could have an impact on the diagnosis and treatment of XL-ED-ID patients. 相似文献
55.
56.
Hama M Uehara T Takase K Ihata A Ueda A Takeno M Shizukuishi K Tateishi U Ishigatsubo Y 《Rheumatology international》2012,32(5):1327-1333
To evaluate the responsiveness of power Doppler ultrasonography (PDUS) in comparison with conventional measures of disease
activity and structural damage in rheumatoid arthritis (RA) patients receiving tocilizumab (TCZ). Seven RA patients with active
arthritis were enrolled in the study and prospectively monitored for 12 months. They were treated with TCZ (8 mg/kg) every
4 weeks as monotherapy or in combination with disease-modifying antirheumatic drugs (DMARDs). Clinical, laboratory, and ultrasound
examinations were conducted at baseline, 1, 3, 6, 9, and 12 months. Power Doppler (PD) signals were graded from 0 to 3 in
24 joints, and total PD score was calculated as the sum of scores of individual joints. One-year radiographic progression
of the hands was estimated by using Genant-modified Sharp scoring. The averages of the clinical parameters rapidly improved,
and all patients achieved good response within 6 months based on standard 28-joint Disease Activity Score (DAS28). Although
the average total PD score declined in parallel with clinical improvement, radiography of the hands showed progression of
destruction in the joints where PD signals remained, even among clinical responders. ΔSharp score correlated with the time-integrated
value (TIV) of total PD scores (Δtotal Sharp score: r = 0.77, P = 0.04; Δerosion: r = 0.78, P = 0.04; Δjoint-space narrowing (JSN): r = 0.75, P = 0.05), but not with TIVs of clinical parameters including DAS28. PDUS can independently evaluate disease activity in RA
patients receiving TCZ and is superior to DAS28, especially in predicting joint destruction. 相似文献
57.
58.
59.
60.
Ito Y Fukushima M Kihara M Takamura Y Kobayashi K Miya A Miyauchi A 《Endocrine journal》2012,59(6):457-464
In papillary thyroid carcinoma (PTC), extrathyroid extension (Ex) and clinical lymph node metastasis (N) significantly affect the prognosis. We investigated the prognosis of patients with PTC 1 cm or less (1,220 patients), 1.1-2 cm (2,101 patients), 2.1-3 cm (1,249 patients), 3.1-4 cm (645 patients), and larger than 4 cm (563 patients). We classified N factor into three categories: N0, no clinical node metastasis: N1, clinical node metastasis smaller than 3 cm and without extranodal tumor extension requiring at least partial excision of adjacent organs for node dissection: and N2, clinical node metastasis 3 cm or larger or showing extranodal tumor extension. N2 markedly affected lymph node and distant recurrence-free survivals and cause-specific survival, regardless of the tumor size. N1 also adversely affected lymph node and distant recurrence-free survival but not cause-specific survival. Ex did not affect patients' prognosis with PTC 1 cm or less. It became a prognostic factor with PTC larger than 1 cm, and worsened lymph node and distant recurrence-free survival not only for N0 but also for N1 PTC larger than 3 cm and larger than 2 cm, respectively. However, its influence is limited for N2 PTC patients. Furthermore, Ex worsened the CSS with PTC larger than 2 cm in combination with N2. We have to note that the prognostic significance for lymph node and distant recurrence-free and cause-specific survival of Ex and N varies according to the tumor size in order to accurately predict the clinical outcomes and establish therapeutic strategies for PTC patients. 相似文献