阴道平滑肌肉瘤1例报道并文献复习

目的探讨阴道平滑肌肉瘤的临床特点、诊治方法及预后。方法收集并分析大连大学附属中山医院2017年6月30日收治的1例经病理证实为阴道平滑肌肉瘤患者的临床资料,并回顾分析相关文献。结果该患者自二次手术后再次复发,经25次放疗后带瘤生存1年未发现肿瘤进展迹象。结论彻底手术切除肿瘤对于阴道平滑肌肉瘤患者的预后有重要意义,即使术后局部复发,若及时再次手术对患者预后延长生命具有积极影响,且术后及时辅以放疗可能使患者获益。     

口部运动时面部相关联标记点运动的三维定量分析

目的定量描述口部运动时,与其相关联的面部标记点运动,以探索评价面瘫、面肌联带运动的三维定量新方法。方法健康志愿者22人(45-60岁),利用"基于运动捕捉的面肌运动三维动态分析系统",采集"用力示齿"、"向右上拉口角"、"向左上拉口角"、"微笑"四个表情动作时,面部相关联标记点(眉弓点、上下眼睑点、内眦点、外眦点)的运动,以最大移动距离(Smax)和最大速率(Vmax)两个参数描述。结果 1.口周运动为主的表情动作中,面部其他部位标记点均有运动,且与位于口周的标记点在某一表情运动中其达到Smax或Vmax的时间分别是一致的。2."用力示齿"动作:Smax下眼睑点(左3.93mm,右4.15mm)>外眦点>上眼睑点>眉弓点>内眦点(左1.59mm,右1.53mm);Vmax眼睑点左上(42.643mm/s)>余眼睑标记点(31.58mm/s-37.62mm/s)>外眦点>眉弓点>内眦点(左11.71mm/s,右11.09mm/s)。3."微笑"动作:Smax及Vmax上眼睑点(左3.05mm,36.14mm/s;右2.53mm,28.90mm/s)>下眼睑点>外眦点>眉弓点>内眦点(左0.69mm,7.22mm/s;右0.77mm,7.80mm/s)。4."向右上拉口角"动作,Smax及Vmax外眦点及下眼睑点右侧明显大于左侧,内眦点右侧略大于左侧,上眼睑点、眉弓点左侧略大于右侧。5."向左上拉口角"Smax及Vmax外眦点、上眼睑点、下眼睑点左侧明显大于右侧,余标记点左侧略大于右侧。结论健康人进行口部运动时,会引起面部其他部位标记点发生相关联的运动,其达到Smax或Vmax的时间分别是一致的。在同一表情动作中,上、下眼睑点及外眦点的Smax、Vmax大于内眦点、眉弓点。Smax及Vmax的较小值出现于"微笑"动作内眦点;较大值出现于"用力示齿"动作下眼睑点。"向左上拉口角"动作同侧面部标记点Smax及Vmax均大于对侧相对称部位标记点。表情动作时面部无静止点。     

Comparative study of CD4 and CD45RO T cells and CD20 B cells in cerebrospinal fluid of syphilitic meningitis and tuberculous meningitis patients

This study was to investigate the differences of lymphocyte in the cerebrospinal fluid (CSF) of patients with syphilis meningitis (SM) and tuberculous meningitis (TBM) for new diagnostic insights. Totally, 79 cases of SM and 45 cases of TBM were enrolled. In the CSF, the CD4, CD45RO or CD20 positive lymphocytes were detected by immunohistochemistry. The proportion of CD4 T cells in the CSF lymphocytes in patients with SM was significantly higher than that in patients with TBM (p < 0.05). After medical therapy, there was a significantly decline trend of the CD4 T‐cell proportion in both groups (p < 0.05). The proportion of CD45RO T cells in CSF lymphocytes of patients with SM was less than that of patients with TBM (p < 0.05). After medical therapy, the positive ratio of CD45RO T cells was increased in the CSF of both group patients (p < 0.05). The proportion of CD20B cells in the CSF lymphocytes was not obviously different between the two groups during every stage. In conclusion, there are strong differences of CD4 and CD45RO T‐cell ratio, but not the CD20 B cells in the meningitis. CD4 and CD45RO T cells in CSF are a useful complement in differentially diagnosing SM and TBM; it contributes to further understand the pathogenesis and prognosis of SM and TBM.     

Changing paradigms in clinical oncology research �� Highlights from the 2011 ASCO annual meeting and beyond

In this review, some important clinical advances presented at the 2011 American Society of Clinical Oncology (ASCO) meeting are summarized. Emerging trends in clinical oncology research are also discussed based on an analysis of the ASCO abstract database in recent years.     

疏血通联合银杏达莫治疗急性脑梗死疗效分析

目的观察疏血通联合银杏达莫治疗急性脑梗死患者的临床疗效。方法按标准选择急性脑梗死患者84例,随机分为治疗组和对照组,每组各42例。治疗组给予疏血通联合银杏达莫治疗,对照组给予银杏达莫治疗,疗程均为14 d.观察2组临床疗效及血脂、凝血指标等的变化。结果治疗组临床疗效优于对照组（P〈0.05）,血脂、凝血指标均有明显改善（P〈0.05）。结论疏血通联合银杏达莫治疗急性脑梗死疗效确切,且安全性好。     

肝脏囊型包虫病的弥散成像及囊液分析对照研究

目的：通过对一组肝脏包虫囊肿和非寄生虫性囊肿进行弥散成像以及囊液的生化值的分析，帮助鉴别仅凭单纯影像和血清学试验无法作出肯定诊断的包虫囊肿，并进一步分析研究包虫囊肿和非寄生虫性囊肿囊液的代谢物、电解质、葡萄糖和蛋白质浓度存在差异。资料和方法：通过对29例肝脏囊型包虫病患者以及17例肝脏单纯性囊肿患者进行弥散成像，取其中20例肝脏囊性病灶囊液（其中包虫囊肿13例，非寄生虫性囊肿7例）进行电解质、葡萄糖和蛋白质浓度生化测定。结果：肝脏包虫囊肿在b值1 000 mm/s2弥散图像上ADC值低于肝脏单纯性囊肿，差异有统计学意义，13例肝脏包虫囊肿囊液中葡萄糖、钙离子浓度高于非寄生虫性囊肿，两者间差异有统计学意义。结论：通过肝脏弥散成像可以帮助鉴别包虫囊肿和单纯性囊肿，尤其是早期包虫囊肿，包虫囊肿囊液的葡萄糖含量高于单纯性囊肿，而蛋白含量两者无统计学差异，推测葡萄糖作为大分子物质吸附水分子而导致水分子弥散受限。