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141.
142.
Heather S. Jim Michael A. Andrykowski Pamela N. Munster Paul B. Jacobsen 《Annals of behavioral medicine》2007,34(2):200-208
Background: Studies suggest that the period following completion of treatment can be distressing for cancer patients. One potentially
important predictor of distress is physical symptoms/side effects during treatment.Purpose: A longitudinal, observational design was used to examine whether the number of physical symptoms/side effects experienced
during treatment was a correlate of cancer-related distress and general distress 4 months after treatment completion, as measured
by the Impact of Events Scale and the Mental Health subscale of the Short Form-36, respectively.Methods: Participants were 151 women who had completed chemotherapy and/or radiotherapy for ductal carcinoma in situ or stage 1 or
2 breast cancer. Hierarchical multiple regression was conducted with relevant sociodemographic, clinical, and psychiatric
variables entered as controls.Results: Greater physical symptoms/side effects predicted greater total cancer-related distress, intrusive thoughts, and general distress.
Physical symptoms/side effects did not significantly predict avoidance. Follow-up analyses indicated that the relationship
between physical symptoms/side effects and general distress was mediated by both total cancer-related distress and intrusive
thoughts.Conclusions: These results suggest that patients who experience greater physical symptoms/side effects during treatment are at greater
risk for later cancer-related distress and, in turn, general distress. Future research should evaluate whether early intervention
with these patients is effective in preventing or reducing distress in the posttreatment period.
This work was supported by a grant from the National Cancer Institute (5R01 CA082822). 相似文献
143.
Summary: To develop a method for identification of differential gene expression between different cell populations, several convenient techniques of molecular biology, including subtractive hybridization, suppression PCR, T/A cloning and sequencing, were used to identify genes expressed differentially in CD45^- and CD45^- cells isolated from U266 cell line of multiple myeloma. Our results showed that the levels of abundant genes scale down 20 times through subtractive hybridization.Plasmid DNA from CD45^- cell clones was hybridized with forward or backward cDNA probes synthesized from CD45^- and CD45 cells, respectively. A few of differentially expressed genes reconfirmed by RT-PCR were identified from 500 expressed clones of CD45^- cells. It is concluded that a strategy for gene expression identification developed from conventional molecular biological methods can be used in different laboratories. 相似文献
144.
145.
Daniel M. Herron 《Journal of gastrointestinal surgery》2004,8(4):406-407
Conclusion In the year 2003 there is no “one best bariatric operation” for every severely obese patient. The choice of operation must
be tailored to each individual patient’s needs and wishes. For the superobese patient, the patient diagnosed with intestinal
metaplasia of the stomach, and for those patients who do not wish to undergo the severe dietary restrictions imposed by the
RNY-GB, the BPD-DS is a valuable surgical option. 相似文献
146.
147.
Melinda S. Lantz 《Current Psychosis and Therapeutics Reports》2004,2(1):7-12
Depressive symptoms in older adults are common, but the minority of elderly meet criteria for major depressive disorder. This
has led to confusion regarding the recognition of diagnosis, approach to treatment, and monitoring of outcomes in this needy
population. Few depressed older adults are willing to seek treatment from psychiatrists or mental health specialists. Treatment
approaches to the depressive spectrum of disorders in late life, which encompasses major and minor depressive disorder, dysthymic
disorder, and mood disorders related to medical conditions, must include evidence-based algorithms that can be delivered in
a variety of health care settings. Several recent multisite trials have advanced the use of collaborative care models and
the systematic stepwise approach to the treatment of depression and anxiety states in older adults. This offers the ability
to provide effective treatment of depression for older adults, consistent with current guidelines, in primary care and specialized
health care settings. 相似文献
148.
抑郁障碍对血液透析患者的影响 总被引:1,自引:0,他引:1
目的 探讨尿毒症患者产生抑郁障碍的可能因素及其对血液透析的影响,并尝试药物治疗,改善患者的生活质量。方法 选择无精神病史的规律性血透患者51例,进行汉密尔顿抑郁量表(HAMD,24项版本)评分,并分为抑郁组和非抑郁组;在组间进行性别、年龄、文化程度和经济状况的比较,观察患者透析充分性、营养、就业率及顺应性在组间的差异。选择重度抑郁状态者予博乐欣(75-150mg/d)抗抑郁治疗,观察疗效。结果 (1)35.3%的患者存在抑郁障碍;(2)两组的年龄、性别、文化程度和婚姻障碍情况均无显著差异;(3)两组间在医疗付费方式、透前规律性肾科门诊及顺应性、充分性、营养状态方面存在显著差异;(4)在18例中选7例抗抑郁治疗,1个月后HAMD评分均有不同程度下降。结论 抑郁障碍在血透患者中是常见的。它可造成血透患者的顺应性下降、营养不良、透析不充分等。抗抑郁的药物治疗可望改善患者的抑郁状态。 相似文献
149.
150.
目的 研究细胞周期依赖性蛋白激酶5(cyclin dependent kinases 5,CDK5)在耐药性癫(癎)患者颞叶中的表达,探索其在耐药性癫(癎)发病机制中的作用.方法 收集耐药性癫(癎)患者术后脑组织,用荧光定量PCR、免疫组化和Western blot 3种检测方法从基因和蛋白水平分别测定CDK5在耐药性癫(癎)患者颞叶中的表达,并与对照组进行比较.结果 荧光定量PCR发现CDK5 mRAN比对照组明显增加,免疫组化检测显示这种基因的蛋白表达产物主要分布在神经元轴突和胶质细胞中,Western blot检测在相对分子质量35 000处有一蛋白条带,并且可见实验组(颞叶和海马中分别为1.4293±0.1839和2.0733±0.4738)高于对照组(颞叶和海马中分别为0.9680±0.4147和1.403±0.6163,P<0.05).结论 CDK5在耐药性癫(癎)患者颞叶中表达增强,提示他们可能参与了耐药性癫(癎)的形成. 相似文献