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11.
I?Satish?RaoEmail author Anand?C?Loya KS?Ratnakar VR?Srinivasan 《BMC clinical pathology》2005,5(1):11
Background
Lymph node infarction is known to occur in association with many non-neoplastic and neoplastic conditions however its occurrence in association with DIC is not reported hitherto in the literature. 相似文献12.
Staska LM Davies CJ Brown WC McGuire TC Suarez CE Park JY Mathison BA Abbott JR Baszler TV 《Infection and immunity》2005,73(3):1321-1329
Previously, our laboratory showed that Holstein cattle experimentally infected with Neospora caninum develop parasite-specific CD4+ cytotoxic T lymphocytes (CTL) that lyse infected, autologous target cells through a perforin-granzyme pathway. To identify specific parasite antigens inducing bovine CTL and helper T-lymphocyte responses for vaccine development against bovine neosporosis, the tachyzoite major surface proteins NcSAG1 and NcSRS2 were targeted. In whole tachyzoite antigen-expanded bovine T-lymphocyte lines, recombinant NcSRS2 induced potent memory CD4+- and CD8+-T-lymphocyte activation, as indicated by proliferation and gamma interferon (IFN-gamma) secretion, while recombinant NcSAG1 induced a minimal memory response. Subsequently, T-lymphocyte epitope-bearing peptides of NcSRS2 were mapped by using overlapping peptides covering the entire NcSRS2 sequence. Four experimentally infected cattle with six different major histocompatibility complex (MHC) class II haplotypes were the source of immune cells used to identify NcSRS2 peptides presented by Holstein MHC haplotypes. NcSRS2 peptides were mapped by using IFN-gamma secretion by rNcSRS2-stimulated, short-term T-lymphocyte cell lines, IFN-gamma enzyme-linked immunospot (ELISPOT) assay with peripheral blood mononuclear cells, and 51Cr release cytotoxicity assay of rNcSRS2-stimulated effector cells. Four N. caninum-infected Holstein cattle developed NcSRS2 peptide-specific T lymphocytes detected ex vivo in peripheral blood by IFN-gamma ELISPOT and in vitro by measuring T-lymphocyte IFN-gamma production and cytotoxicity. An immunodominant region of NcSRS2 spanning amino acids 133 to 155 was recognized by CD4+ T lymphocytes from the four cattle. These findings support investigation of subunit N. caninum vaccines incorporating NcSRS2 gene sequences or peptides for induction of NcSRS2 peptide-specific CTL and IFN-gamma-secreting T lymphocytes in cattle with varied MHC genotypes. 相似文献
13.
Kim Si Hyun Park Jae Joon Kim Ki Hong Yang Hee Jo Kim Doo Sang Lee Chang Ho Jeon Youn Soo Shim Sung Ryul Kim Jae Heon 《International urology and nephrology》2021,53(9):1733-1746
International Urology and Nephrology - Late onset hypogonadism (LOH) is an age-dependent reduction of testosterone associated with alterations of metabolic profile, including glucose control,... 相似文献
14.
15.
Xuan-Mei Piao Ho Won Kang Pildu Jeong Young Joon Byun Hee Youn Lee Kyeong Kim Sung Phil Seo Won Tae Kim Jong-Young Lee Yun-Sok Ha Yung Hyun Choi Sung-Kwon Moon Seok Joong Yun Wun-Jae Kim 《Urologic oncology》2021,39(4):237.e21-237.e29
BackgroundThere is an increasing demand for prognostic immune biomarkers of cancer. The prognostic significance of immune markers has been shown for various cancers, but biomarkers of bladder cancer (BCa) have not been fully evaluated. To clarify the role of human leukocyte antigen DR alpha chain (HLA-DRA) in BCa development, we examined expression of HLA-DRA mRNA in tissue samples of non-muscle invasive bladder cancer (NMIBC) and muscle invasive bladder cancer (MIBC).Materials and MethodsTissues of 96 NMIBC, 43 MIBC and 59 controls comprising noncancerous BCa surrounding tissues were used to examine the expression of HLA-DRA gene by real-time polymerase chain reaction. The expression of up-stream genes regulating HLA-DRA were also measured to explain the role of HLA-DRA in BCa.ResultsPatients with high grade NMIBC showed higher expression of HLA-DRA than those with low grade NMIBC (P < 0.05). In addition, NMIBC patients who progressed to MIBC showed high expression of HLA-DRA mRNA. Kaplan-Meier analysis showed that NMIBC patients with low expression of HLA-DRA had better progression-free survival than those with high expression (P = 0.004). Moreover, the expression of genes regulating HLA-DRA varied in NMIBC and MIBC, indicating a different immunoregulation effect of HLA-DRA in both cancers.ConclusionsHigh expression of HLA-DRA in NMIBC patients has implications for patient stratification strategies, as well as for BCa tumor immunology. 相似文献
16.
S S Yoon H D Youn C Suh Y J Bang S J Choi B K Kim N K Kim E C Kim 《Journal of Korean medical science》1987,2(4):255-258
One case of arthritis complicating leukemia is described in which leukemic cells were identified in synovial fluid by light microscopy. Although arthritis is a well-known manifestation of leukemia with an incidence of 13.5%, the pathogenesis often is unclear, and the direct demonstration of leukemic cells in synovial fluid has been very uncommon. A 16 year-old male patient was admitted due to left elbow joint pain and swelling. Synovial fluid examination revealed blast cells and this finding has directed to a final diagnosis of acute lymphoblastic leukemia. 相似文献
17.
Acute porphyria is rare in orientals. We describe a Chinese woman with recurrent generalised tonic-clonic seizures and abdominal pain. Genomic DNA studies identified a heterozygous base substitution from guanine to adenine at nucleotide position 503, resulting in substitution of arginine by histidine at position 168 of the protein (R168H). This genetic abnormality is similar to the mutation reported in Caucasians with variegate porphyria. To the best of our knowledge, this is the first report in the English literature a Chinese patient with variegate porphyria with an identifiable mutation. A brief review of porphyria is presented. 相似文献
18.
H. S. Youn G. H. Ko M. H. Chung W. K. Lee M. J. Cho K. H. Rhee 《Journal of Korean medical science》1996,11(5):373-385
In many Western developed countries, the incidence of stomach cancer has declined dramatically. This decrease was an extraordinary, "unplanned triumph", especially when compared to other cancers. Stomach cancer is still the most prevalent malignant tumor in Korea. Most Koreans carry Helicobacter pylori in their stomach. Thus, a new hypothesis, based on the relationship between the host and Helicobacter pylori, is presented as the carcinogenesis of human stomach cancer. The reasons for why the N-nitrosamide hypothesis should be dismissed as the etiology of stomach cancer, and why the contemporarily available principles and practice of intervention strategies to rapidly decrease the surprisingly high prevalence rate of Helicobacter pylori infection are impractical at this moment, are explained. In order to introduce an alternative provisional strategy of the "planned triumph" for the population vulnerable to stomach cancer, vitamin C is defined as an anti-inflammatory agent on the basis of the pathogenesis of Helicobacter pylori infection. 相似文献
19.
Gahyun Youn Ph.D. 《Archives of sexual behavior》1996,25(6):629-643
Data regarding the sexual behaviors of 849 Korean adolescents (
years) were collected. Behaviors reported for males vs. females were 36.5 vs. 27.0% for kissing, 27.2 vs. 14.8% for petting,
and 22.9 vs. 9.8% for coitus. In addition to reporting a greater number of experiences, males reported a greater number of
partners for all three behavior categories. Among those who participated in coitus, nearly one third of the males and two
thirds of the females reported only one partner. Two thirds of the males considered their recent experiences with coitus to
be satisfactory, whereas over half of the females gave a neutral response. About 37% of males and 55% of females reported
that their most recent coital experience was less than a month ago. On average, the coitally active adolescents began sexual
activity at about 18 years of age. Interpretations of these data must take into consideration the respondents' hesitancy in
the Korean setting to admit to having sexual experiences. Because premarital sex for adolescents is considered very undesirable
in the Korean social setting, the respondents' reporting bias might be in the direction of underreporting. Findings are discussed
in the context of unplanned pregnancy and abortion.
This investigation was supported by the Special Programme of Research, Development and Research Training in Human Reproduction,
World Health Organization, Project No. 91207 BSDA. 相似文献
20.
M elikta N Okur KS Aikimbaev F Binokay M Sert E Akgül 《Journal of Medical Imaging and Radiation Oncology》2004,48(3):398-400
Pheochromocytomas of the bladder are rare neoplasms, constituting <0.06% of all vesical tumours. Common presenting features of this tumour include episodes of sweating, hypertension, haematuria and postmicturition syncope. We describe a case of bladder pheochromocytoma in a 66‐year‐old man whose only symptom of macroscopic haematuria was initially assessed with ultrasonography. Clinical presentation highlights the need for a high index of suspicion during sonographic evaluation of bladder neoplasms because such tumours might present without symptoms of adrenergic excess. 相似文献