全文获取类型
收费全文 | 1368411篇 |
免费 | 103406篇 |
国内免费 | 6612篇 |
专业分类
耳鼻咽喉 | 17072篇 |
儿科学 | 44067篇 |
妇产科学 | 36715篇 |
基础医学 | 201332篇 |
口腔科学 | 36587篇 |
临床医学 | 133941篇 |
内科学 | 262986篇 |
皮肤病学 | 26676篇 |
神经病学 | 113143篇 |
特种医学 | 49294篇 |
外国民族医学 | 381篇 |
外科学 | 187501篇 |
综合类 | 34746篇 |
现状与发展 | 8篇 |
一般理论 | 462篇 |
预防医学 | 116770篇 |
眼科学 | 29977篇 |
药学 | 102620篇 |
30篇 | |
中国医学 | 5253篇 |
肿瘤学 | 78868篇 |
出版年
2021年 | 12786篇 |
2019年 | 12785篇 |
2018年 | 17540篇 |
2017年 | 13471篇 |
2016年 | 14311篇 |
2015年 | 16838篇 |
2014年 | 22860篇 |
2013年 | 33949篇 |
2012年 | 46867篇 |
2011年 | 49682篇 |
2010年 | 29000篇 |
2009年 | 26474篇 |
2008年 | 44593篇 |
2007年 | 46794篇 |
2006年 | 46866篇 |
2005年 | 44949篇 |
2004年 | 42604篇 |
2003年 | 40395篇 |
2002年 | 39075篇 |
2001年 | 61453篇 |
2000年 | 63116篇 |
1999年 | 52856篇 |
1998年 | 14976篇 |
1997年 | 13661篇 |
1996年 | 13453篇 |
1995年 | 12785篇 |
1994年 | 11920篇 |
1993年 | 11089篇 |
1992年 | 41746篇 |
1991年 | 40905篇 |
1990年 | 39554篇 |
1989年 | 37434篇 |
1988年 | 34685篇 |
1987年 | 33786篇 |
1986年 | 32230篇 |
1985年 | 30693篇 |
1984年 | 23057篇 |
1983年 | 19606篇 |
1982年 | 11758篇 |
1979年 | 20813篇 |
1978年 | 14816篇 |
1977年 | 12064篇 |
1976年 | 11877篇 |
1975年 | 12111篇 |
1974年 | 14800篇 |
1973年 | 14472篇 |
1972年 | 13357篇 |
1971年 | 12418篇 |
1970年 | 11485篇 |
1969年 | 10410篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
201.
Reevaluation of procarbazine for the treatment of recurrent malignant central nervous system tumors 总被引:1,自引:0,他引:1
Ninety-nine patients with primary recurrent malignant tumors of the central nervous system were treated with procarbazine as a single agent. Procarbazine was not given as a specified protocol, but for patients who were ineligible or refused other protocols. All patients had been treated previously with radiotherapy and 96 patients had also received previous chemotherapy. Twenty-five patients were treated at the first progression of their tumor, 47 were treated at the second progression, and 27 were treated at the third progression of their tumor. For the aggregate, the response plus stabilization rate was 27% for glioblastoma multiforme with median time to tumor progression of 30 weeks, and 28% for other anaplastic gliomas with a median time to tumor progression of 49 weeks. With respect to the percent of patients who responded or stabilized to treatment, these results are inferior to those reported previously for patients treated with procarbazine at recurrence. With respect to duration of response and stabilization, the data are comparable. 相似文献
202.
203.
204.
R. OREN Y. MAARAVI F. KARMELI G. KENET L. ZEIDEL A. HUBERT & R. ELIAKIM 《Alimentary pharmacology & therapeutics》1997,11(2):341-345
Background : Methimazole, an anti-thyroid drug, was recently found to be useful in the treatment of systemic lupus erythematosus and other autoimmune diseases. Moreover, decreased thyroid hormone production is associated with a variety of immunological manifestations, such as reduced activation of CD4+ cells, increased CD8+ cell activity and reduced soluble IL-2 receptors. In the present study we examined the effects of methimazole and propylthiouracil on a rat model of experimental colitis.
Methods : Colitis was induced by intracolonic administration of 30 mg trinitrobenzene sulphonic acid (TNB). Two weeks prior to induction of colitis, rats were treated by either methimaziole (0.04%) or propylthiouracil (0.01%) in drinking water after a week of free access to water. Rats were sacrificed 48 h or 7 days after induction of colitis. The colon was isolated, rinsed with ice-cold water and weighed. Damage was assessed both macroscopically and microscopically and myeloperoxidase (MPO) activity determined.
Results : All treated rats were hypothyroid as manifested by a significant elevation of thyroid stimulating hormone (TSH), by comparison with the control groups (mean -1.82±0.40 versus 0.11±0.02 mmol/L, respectively). The inflammatory response elicited by TNB resulted in severe mucosal damage 48 h after damage induction, which persisted for 7 days. Pre-treatment with either methimazole 0.04% or propylthiouracil 0.01% significantly decreased mucosal damage macroscopically (lesion area, lesion score and segmental weight) microscopically and also significantly decreased MPO level at both time points ( P <0.01).
Conclusions : Methimazole and propylthiouracil significantly reduce mucosal damage and colonic weight in a rat model of colitis. The mode by which they do so remains to be studied. 相似文献
Methods : Colitis was induced by intracolonic administration of 30 mg trinitrobenzene sulphonic acid (TNB). Two weeks prior to induction of colitis, rats were treated by either methimaziole (0.04%) or propylthiouracil (0.01%) in drinking water after a week of free access to water. Rats were sacrificed 48 h or 7 days after induction of colitis. The colon was isolated, rinsed with ice-cold water and weighed. Damage was assessed both macroscopically and microscopically and myeloperoxidase (MPO) activity determined.
Results : All treated rats were hypothyroid as manifested by a significant elevation of thyroid stimulating hormone (TSH), by comparison with the control groups (mean -1.82±0.40 versus 0.11±0.02 mmol/L, respectively). The inflammatory response elicited by TNB resulted in severe mucosal damage 48 h after damage induction, which persisted for 7 days. Pre-treatment with either methimazole 0.04% or propylthiouracil 0.01% significantly decreased mucosal damage macroscopically (lesion area, lesion score and segmental weight) microscopically and also significantly decreased MPO level at both time points ( P <0.01).
Conclusions : Methimazole and propylthiouracil significantly reduce mucosal damage and colonic weight in a rat model of colitis. The mode by which they do so remains to be studied. 相似文献
205.
206.
STEPHEN K. DORDUNOO JAMES L. FORD MICHAEL H. RUBINSTEIN 《The Journal of pharmacy and pharmacology》1997,49(4):390-396
The effect of storage on the physical stability of solid dispersions of triamterene or temazepam in polyethylene glycols was studied using differential scanning calorimetry (DSC), particle-size analysis and dissolution methods. The enthalpies of fusion of the carriers, without included drug and previously fused and crystallized, increased on storage. Analysis of similarly treated solid dispersions, containing either 10% temazepam or 10% triamterene, showed that each drug influenced the morphology of the polyethylene glycol (PEG). The enthalpies and melting points of the solidus components of the dispersions' carriers were initially reduced after preparation, but on storage these increased. The particle sizes of the drugs dispersed in the PEGs increased on storage. The changes in dissolution after storage of triamterene or temazepam dispersions were smaller for dispersions in PEG 1500 than for dispersions in PEGs of higher molecular weight (PEG 2000, PEG 4000 or PEG 6000) in which the reduction in dissolution was particularly marked during the first month of storage. The rank order of changes in dissolution were PEG 1500 ? PEG 2000 < PEG 4000 ~ PEG 6000. 相似文献
207.
H. Nilsson J. Johansson K. Svanberg S. Svanberg G. Jori E. Reddi A. Segalla D. Gust A. L. Moore T. A. Moore 《British journal of cancer》1997,76(3):355-364
The biodistribution of two recently developed tumour markers, trimethylated (CP(Me)3) and trimethoxylated (CP(OMe)3) carotenoporphyrin, was investigated by means of laser-induced fluorescence (LIF) after i.v. injection into 38 tumour-bearing (MS-2 fibrosarcoma) female Balb/c mice. At 3, 24, 48 or 96 h after administration, the carotenoporphyrin fluorescence was measured in tumoral and peritumoral tissue, as well as in the abdominal, thoracic and cranial cavities. The fluorescence was induced by a nitrogen laser-pumped dye laser, emitting light at 425 nm, and analysed by a polychromator equipped with an image-intensified CCD camera. The fluorescence was evaluated at 490, 655 and 720 nm: the second and third wavelengths represent the carotenoporphyrin (CP)-related peaks, whereas the first one is close to the peak of the tissue autofluorescence. The tumour and the liver were the two tissue types showing the strongest carotenoporphyrin-related fluorescence, whereas the cerebral cortex and muscle consistently exhibited weak substance-related fluorescence. In most tissue types, the fluorescence intensities decreased over time. A few exceptions were observed, notably the liver, in which the intensity remained remarkably constant over the time period investigated. 相似文献
208.
A wound, in the broadest sense, is a disruption of normal anatomic structure and function. Acute wounds progress through a timely and orderly sequence of repair that leads to the restoration of functional integrity. In chronic wounds, this timely and orderly sequence goes awry. As a result, people with chronic wounds often face not only physiological difficulties but emotional ones as well. The study of body image and its damage as a result of a chronic wound fits well with Selder's transition theory. This article describes interviews with seven patients with chronic wounds. The themes that emerged from those interviews were compared with Selder's theory to describe patients' experience with chronic wounds as a transition process that can be identified and better understood by healthcare providers. 相似文献
209.
210.
Changes on serial assessments of brain MRI lesion load are used for monitoring therapeutic efficacy in patients with multiple
sclerosis (MS). We assessed the accuracy and reliability of conventional spin-echo (CSE) and fast spin-echo (FSE) sequences
for measurement of lesion volume using a semiautomated contour technique. Cranial CSE and FSE examinations of 18 patients
with secondary progressive MS were studied. The mean lesion load was slightly higher with the CSE sequence (p = 0.002). Intraobserver
variability was significantly higher for FSE than for CSE, according to both the coefficient of variation between two measurements
(mean 2.48 % and 1.35 % respectively, p < 0.05) and back-transformed 95 % limits of agreement (1.005–1.060 for FSE; 0.988–1.019
for CSE). Although FSE sequences are quicker and the total lesion volume measurements are similar to those obtained with CSE,
the poorer reproducibility raises doubts about the use of FSE to replace CSE in clinical trials.
Received: 26 March 1996 Accepted: 4 April 1996 相似文献