全文获取类型
收费全文 | 478778篇 |
免费 | 33877篇 |
国内免费 | 8479篇 |
专业分类
耳鼻咽喉 | 6210篇 |
儿科学 | 9555篇 |
妇产科学 | 11648篇 |
基础医学 | 66426篇 |
口腔科学 | 13750篇 |
临床医学 | 42669篇 |
内科学 | 94014篇 |
皮肤病学 | 9865篇 |
神经病学 | 33651篇 |
特种医学 | 17762篇 |
外国民族医学 | 137篇 |
外科学 | 71609篇 |
综合类 | 21655篇 |
现状与发展 | 22篇 |
一般理论 | 88篇 |
预防医学 | 23798篇 |
眼科学 | 12860篇 |
药学 | 41102篇 |
68篇 | |
中国医学 | 6527篇 |
肿瘤学 | 37718篇 |
出版年
2022年 | 3881篇 |
2021年 | 6974篇 |
2020年 | 4742篇 |
2019年 | 5784篇 |
2018年 | 7871篇 |
2017年 | 6215篇 |
2016年 | 6364篇 |
2015年 | 8102篇 |
2014年 | 10779篇 |
2013年 | 12117篇 |
2012年 | 16948篇 |
2011年 | 17659篇 |
2010年 | 10771篇 |
2009年 | 9389篇 |
2008年 | 14490篇 |
2007年 | 15288篇 |
2006年 | 15210篇 |
2005年 | 14051篇 |
2004年 | 12207篇 |
2003年 | 11647篇 |
2002年 | 10794篇 |
2001年 | 31350篇 |
2000年 | 31840篇 |
1999年 | 26800篇 |
1998年 | 6844篇 |
1997年 | 5775篇 |
1996年 | 5021篇 |
1995年 | 4590篇 |
1994年 | 4041篇 |
1993年 | 3478篇 |
1992年 | 17271篇 |
1991年 | 15834篇 |
1990年 | 15099篇 |
1989年 | 14910篇 |
1988年 | 13419篇 |
1987年 | 12746篇 |
1986年 | 11694篇 |
1985年 | 10911篇 |
1984年 | 7281篇 |
1983年 | 5889篇 |
1982年 | 2872篇 |
1979年 | 5698篇 |
1978年 | 3448篇 |
1977年 | 3063篇 |
1975年 | 2728篇 |
1974年 | 3172篇 |
1973年 | 2975篇 |
1972年 | 2927篇 |
1971年 | 2875篇 |
1969年 | 2612篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
11.
目的:观察应力刺激结合温经活血汤治疗骨折延迟愈合的临床疗效。方法:40例随机分成两组各20例,两组均行应力刺激。治疗组给予温经活血汤治疗、对照组给予接骨七厘片治疗。结果:治疗4周、8周两组血清ALP、BGP指标比较差异有统计学意义(P<0.05),治疗4周、8周和治疗结束后4周骨痂评分两组比较差异均有统计学意义(P<0.05),总体疗效治疗组优于对照组(P<0.05)。结论:应力刺激结合温经活血汤治疗骨折延迟愈合疗效较好。 相似文献
12.
13.
We report a Chinese family with members affected by epidermolytic ichthyosis (EI), caused by KRT gene mutations. The proband was a 14‐year‐old boy who had simultaneous appearance of nephroblastoma and epidermolytic ichthyosis (EI). Both the patient and his mother exhibited the specific clinical and pathological manifestations of EI. We analysed all exons and flanking sequences of the KRT1 and KRT10 genes using PCR, and found that the proband and his mother had a G>C transition at nucleotide position 1432 in exon 7 of KRT1, resulting in an amino acid substitution of glutamate (GAA) to glutamine (CAA) at codon 478 (E478Q). The KRT10 gene had no mutations. 相似文献
14.
Autoimmune comorbid diseases associated with lichen planus: a nationwide case–control study
下载免费PDF全文
![点击此处可从《Journal of the European Academy of Dermatology and Venereology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
15.
Loss‐of‐function mutations in the gene encoding filaggrin underlie a Japanese family with food‐dependent exercise‐induced anaphylaxis
下载免费PDF全文
![点击此处可从《Journal of the European Academy of Dermatology and Venereology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
16.
Y.R. Song B. Wu Y.T. Yang J. Chen L.J. Zhang Z.W. Zhang H.Y. Shi C.L. Huang J.X. Pan P. Xie 《Brazilian journal of medical and biological research》2015,48(11):973-982
Bipolar disorder (BD) is a common psychiatric mood disorder affecting more than 1-2%
of the general population of different European countries. Unfortunately, there is no
objective laboratory-based test to aid BD diagnosis or monitor its progression, and
little is known about the molecular basis of BD. Here, we performed a comparative
proteomic study to identify differentially expressed plasma proteins in various BD
mood states (depressed BD, manic BD, and euthymic BD) relative to healthy controls. A
total of 10 euthymic BD, 20 depressed BD, 15 manic BD, and 20 demographically matched
healthy control subjects were recruited. Seven high-abundance proteins were
immunodepleted in plasma samples from the 4 experimental groups, which were then
subjected to proteome-wide expression profiling by two-dimensional electrophoresis
and matrix-assisted laser desorption/ionization-time-of-flight/time-of-flight tandem
mass spectrometry. Proteomic results were validated by immunoblotting and
bioinformatically analyzed using MetaCore. From a total of 32 proteins identified
with 1.5-fold changes in expression compared with healthy controls, 16 proteins were
perturbed in BD independent of mood state, while 16 proteins were specifically
associated with particular BD mood states. Two mood-independent differential
proteins, apolipoprotein (Apo) A1 and Apo L1, suggest that BD pathophysiology may be
associated with early perturbations in lipid metabolism. Moreover, down-regulation of
one mood-dependent protein, carbonic anhydrase 1 (CA-1), suggests it may be involved
in the pathophysiology of depressive episodes in BD. Thus, BD pathophysiology may be
associated with early perturbations in lipid metabolism that are independent of mood
state, while CA-1 may be involved in the pathophysiology of depressive episodes. 相似文献
17.
18.
目的以基因表达数据集资料为研究对象,分析BCAN基因在肾透明细胞癌中的表达情况以及对患者预后的影响。方法在Oncomine数据库中挖掘BCAN在肾透明细胞癌(ccRCC)中的表达情况。从TCGA数据库中获取ccRCC患者临床资料和目的基因的表达信息并进行统计分析。利用GEO数据库中GSE73731数据集的ccRCC样本进行基因富集分析。利用String数据库分析与BCAN相关的蛋白。结果BCAN低表达组的ccRCC患者在病理分期及T分期方面低于高表达组(P<0.001;P=0.001);N分期及M分期差异无统计学意义(P>0.05)。BCAN低表达组患者的总生存期优于高表达组(P=0.033)。BCAN基因高表达组的样本主要富集在KRAS信号通路。结论BCAN可以通过多种途径来促进肿瘤细胞的侵袭能力,有望成为ccRCC不良预后的重要生物标志物之一。 相似文献
19.
20.
Nevo N. Goldstein A. L. Staierman M. Eran N. Carmeli I. Rayman S. mnouskin Y. 《Hernia》2022,26(6):1491-1499
Hernia - The minimally invasive surgical repair of combined inguinal and ventral hernias often requires shifting from one approach or plane to another. The traditional enhanced-view totally... 相似文献