磁共振电影成像估价心肌功能

采用磁共振电影成像（Ｃｉｎｅ－ＭＲＩ）估价９例正常人和１３例左心室陈旧心肌梗塞患者的左心室功能状况。其方法是应用小角度翻转角、短ＴＲ和信号聚焦的梯度场成像序列，通过观察左心室各段肌壁运动状态和测量肌壁厚度的变化以判断各段肌壁的运动功能。结果提示，Ｃｉｎｅ－ＭＲＩ无论对心肌壁运动状态的定性还是运动功能的定量均有一定的价值。     

胆道内支架引流术治疗梗阻性黄疸（附12例报告）

笔者对１２例胆道梗阻病人进行了非手术治疗。其中，采用自制“Ｚ”型自张式金属支架（ＥＭＳ）成功地实施经皮经肝或经“Ｔ”型管胆道内支架引流术（ＥＭＢＥ）治疗者８例。８例中，胆道良性梗阻，“Ｔ”型管引流术后２例，胆道恶性梗阻６例。ＥＭＢＥ后，行“Ｔ”型管引流者当日即停止外引流；梗阻性黄疸病人症状迅速消失，黄疸逐日消退。术后随访观察１～１６个月。胆道发生再闭塞２例（１例经再置入一组ＥＭＳ及局部放疗后获得再通）。术后３个月无黄疸死亡１例，其余病例均无黄疸生存。其中１例已１６个月无复发。本组未出现严重的并发症及副作用。笔者认为ＥＭＢＥ操作简便，副作用少，疗效显著，是一种治疗梗阻性黄疸的比较理想的非手术方法。     

冠心病的电影摄影诊断：附23例报告

本文分析２３例冠心病患者的电影摄影所见，着重分析室壁瘤形成与冠状动脉狭窄的程度，部位，数目，仙支血管形成和临床病性等因素的关系，此外，对冠心病中继发二尖瓣返流的成因和机理进行了探讨。讨论中提出以下三点：（１）室壁瘤的发生与冠状动脉主要分支的严重狭窄关系最密切；（２）侧支循环能防止心肌梗塞范围扩大及室壁瘤形成；（３）二尖瓣返流与主要冠状动脉病变的狭窄程序及室壁瘤的存在有关，并对影响侧支循环显示的因素     

后入路脊髓前侧推挤减压治疗胸腰椎损伤

报告５０例后入路全椎板切除，不破坏小关节突和椎弓根，采用作者设计的特殊弧度的骨凿，骨膜剥离器，骨锉和推进器作脊髓前侧推挤减压，Ｄｉｃｋ器械短节段椎弓根内固定和后路植骨融合术。术后和随访神经功能恢复标准，按Ｆｒａｎｋｅｌ氏分级法，６例达到Ｂ级，１６例进入Ｃ级，５例进入Ｄ级，１９例达到Ｅ极。     

海水型呼吸窘迫综合征兔肾皮质酶活性定位和图像分析

采用超微结构细胞化学和图像分析技术，对兔海水型呼吸窘迫综合征（ＳＷ－ＲＤＳ）肾皮质酶活性的变化进行了观察。ＳＷ－ＲＤＳ组肾皮质碱性磷酸酶、５’－核苷酸酶、对－硝基苯磷酸酶和细胞色素氧化酶活性明显下降，而胞嘧啶单核苷酸酶活性明显增强。这表明肾皮质一些酶活性的改变是兔ＳＷ－ＲＤＳ发病机理之一。     

妊娠合并脐带绕颈209例胎心监护分析

２０９例脐带绕颈病人胎心监护发现：４６例出现自然减速，占２０．００％；７８例胎动时ＦＨＲ加速≥２５ｂｐｍ，占３７．３２％；９１例ＯＣＴ或ＣＳＴ中出现变异减速（ＶＤ）６２例，占６８．１３％。自然减速为胎儿宫内不良征象。有反应型ＮＳＴ出现自然减速应按无反应型ＮＳＴ处理。脐带统颈病人胎心监护出现自然减速、胎动时ＦＨＲ加速≥２５ｂｐｍ，或伴发ＶＤ时，羊水污染、低Ａｐｇａｒ评分的发生率明显增加。     

经皮肿瘤内射频治疗肺癌的研究──第二部分：经皮肿瘤内射频治疗肺癌的临床应用

经皮肿瘤内射频治疗肺癌，是将经皮肺穿刺活检技术发展为一种治疗肺癌的方法。在活检以后，通过保留的针管将特高频电磁场导入肿瘤内施行辐射。射频电磁波在生物介质中产生的热及非热效应，凝固癌组织，杀死癌细胞。根据肿瘤大小差异，分别采取单点或多点辐射，使肿瘤破坏更彻底。本技术应用于临床以前，经历了肿瘤模拟物、离体肿瘤、动物实验证实之后（该论文在中华放射学杂志待发）。治疗１０例中晚期肺癌，术后症状改善，ＣＴ扫描、血管造影及再次活检，均证明疗效明显。无并发症发生。     

选择性支气管动脉插管药物治疗中,晚期肺癌

对34例中晚期肺癌进行选择性支气管动脉插管药物灌注.药物为 LAK 细胞,IL-2、卡铂、表阿霉素。结果显示,肿块明显消退12例占35.2%,部分消退18例占52.5%、无变化4例占12.7%、总有效率为87.3%。通过对支气管动脉插管技术,灌注疗法同其它治疗方法的优缺点进行比较,认为本疗法优于周围静脉给药且无严重并发症,副作用轻,不失为一种可供选择的治疗方法.     

Overexpression of bcl-xL Protects Astrocytes from Glucose Deprivation and Is Associated with Higher Glutathione, Ferritin, and Iron Levels

Background: The possibility of altering outcome from ischemia-like injury by overexpressing the anti-cell death gene bcl-xL was studied. Cells are known to die by different pathways including apoptosis, or programmed cell death, and necrosis. The bcl-xL gene is a member of a family of apoptosis regulating genes and often displays the death-inhibiting properties of the prototype of this family, bcl-2. It is of special interest to study bcl-xL for possible brain protection, because, unlike bcl-2, it is important for normal brain development.

Methods: Overexpression of bcl-xL was achieved in primary astrocyte cultures using a retroviral vector. Cultures of astrocytes overexpressing bcl-xL or a control gene were injured by hydrogen peroxide, glucose deprivation, or combined oxygen and glucose deprivation. Outcome was assessed morphologically and by release of lactate dehydrogenase. We assessed antioxidant effects by measuring glutathione using monochlorobimane, ferritin by immunoblotting, the level of iron spectrophotometrically, and superoxide using iodonitrotetrazolium violet and dihydroethidium.

Results: Protection by bcl-xL was found against glucose deprivation and hydrogen peroxide exposure but not combined oxygen and glucose deprivation. Higher levels of superoxide were found, without increased levels of lipid peroxidation. Overexpression of bcl-xL was associated with elevated glutathione levels, elevated ferritin levels, and increased amounts of iron. The increased glutathione contributed to the protection from glucose deprivation.