煤工尘肺HRCT的形态学表现及诊断价值研究

目的：探索煤工尘肺的ＨＲＣＴ特征。方法：１２４例煤工尘肺作肺部常规ＣＴ,然后在主动脉弓顶、隆突水平、气管分叉下３ｃｍ右膈上２ｃｍ及重点兴趣区加作ＨＲＣＴ,对其图像表现进行研究。结果：本组１２４例煤工尘肺ＨＲＣＴ清晰地显示了肺小叶间隔增厚、小叶核心改变及小叶间质增厚、尘肺结节、各型肺气肿和大阴影等病变的特征。结论：ＨＲＣＴ对显示煤工尘肺微细病变的多种形态学表现极有帮助,在鉴别诊断中亦具有重要价值     

高原移居人群肺功能与血浆一氧化氮测定结果分析

目的：探讨高原移居人群低氧初期和居住６个月后的动态肺功能与血浆一氧化氮之间的内在关系,充分认识低氧环境中肺通气功能的变化物调节过程,为急性高原病的防治寻求新的途径;方法：采用美国产ＥＳ８００肺功能仪对同一群体的２０名男性健康青年于上山前（海拔１４００ｍ）和进驻海拔５３８０ｍ１０天及居住６个月后在静息状态下进行动态肺功能及血浆一氧化氮的测定;     

核黄素缺乏症并发霉菌感染的调查研究

本文报道了某工地大批工人突然发生阴囊皮炎的调查研究.共调查了1,736人.发病率为21万.在282名患者中,霉菌阳性者占27.6%.通过多种调查及治疗试验等认为阴囊皮炎的病因主要是核黄素缺乏和伴发霉菌感染.核黄素缺乏的原因是由于它的供应不足.核黄素缺乏和卫生条件差,可能为白色念珠菌为主的霉菌感染创造了条件.随访两年证明所提供的防治措施是行之有效的.     

PRIMARY RESEARCH ON FRACTAL GEOMETRY OF MERIDIAN THEORY

In meridian theory of traditional Chinese medicine(TCM),the geometrical descrip-tions can be traced back to the remote ancient times in China,mainly in The Yellow Emperor‘s In-ternal Classic(The Internal Classic in short).Euclid‘s geometry,topology and other classic mathe-matics are all at their wit‘s end to explain the high complexity and non-clinear phenomenon of the meridian .In recent over2000years.the meridian phenomenon has been being the challenge to funda-mental mathematics.Fractral geometry,founded by Mandelbrot(1975),is a branch of learning for investigating irreg-ular geometrical curves.It has successfully solved some qualitative and quantitative problems about the topographical structure of molecular Brown‘s movement curve and other irregular complicated curves and geomtrical characters.The characteristics of geometrical topographical structure of meridian and its phenomenon belong to the research category of Fractal Geometry.The author of this paper believes that Fractal Geometry may provide a useful mathematical tool and a possible way for revealing the enigma of acup-moxibus-tion meridian theory.The human body is of basic characters of Fractal Geonetry in structure,while meridian is the ex-pression form of Fractal structure of the human body.The basic Fractal geometrical characters of meridian are:self-similarity,self-affinity,symmetry,minute structure and self-avoidance,which has bee applied for thousands of years in clinic,suchas“taking the acupoints on the right side of the body in cases of disorders appearing on the left side and vice versa”.The basic characters of meridians are1)symmetry of the 12regular meridians on the bilateral sides of the body(symmetry);2)similarity in characters and actions of acupoints of the same one meridian(self-similarity);3)taking acupoints on the lower part of the body when disorders occuring on the upper part of the body;and taking acupoints on the upper part of the body if disordera appear-ing on the lower part(self-affinity);4)micro-acupuncture system including hand-acupuncture,foot-acupuncture,scalp-acupuncture,auricular acupuncture and eye-acupuncture(minute structure);and acupuncture,scalp-acupuncture,auricular acupuncture and eye-acupuncture(minute structure);and acupuncture,scalp-acupuncture,auricular acupuncture and eye-acupuncture(minute structure);and acupuncture,scalp-acupuncture,auricular acupuncture and eye-acupuncture(minute structure);and acupuncture,scalp-acupuncture,auricular acupuncture and eye-acupuncture(minute structure);and5)systematical running of needling sensation(self-avoidance).     

氟砷联合染毒对大鼠子代大脑氧化性损伤的研究

目的 揭示氟砷共存时对子代健康的影响。方法 采用两代一窝繁殖实验的方法,测定Ｗｉｓｔａｒ大鼠暴露于氟砷后其子代大脑中氟砷蓄积情况、脂质过氧化水平。结果 随着暴露剂量的增加,大脑氟砷含量显著增加,ＳＯＤ和ＧＳＨ－Ｐｘ活性随之降低,而ＬＰＯ含量却逐渐增加,同代不同剂量组间比较,差异均有非常显著意义（Ｐ〈０．０１）,并出出明显的病理性变化;停止氟砷暴露８周后,大脑氟砷含量显著降低,酶的生有所恢复,而ＬＰ     

慢性缺氧与暗适应

探讨机体持续性慢性缺氧对人光觉系统的影响及可逆性程度 ;方法 :采用暗房夜光表测验法[1 ] ,对驻守在海拔 5 380m 6个月的 46名健康青年官兵现场进行吸氧 1 5分钟前后的暗适应检测 ;结果 :吸氧 1 5分钟后暗适应时间较吸氧前显著缩短 (P <0 .0 1 ) ;结论 :海拔 5 380m持续性慢性缺氧 6个月光感系统可发生功能性的改变 ,暗适应时间延长 ,供氧后光觉功能在短时间内迅速恢复至平原水平。     

喉癌组织中Klotho基因的表达及其临床意义

目的   探讨喉癌组织中Klotho基因的表达及其与临床病理特征的关系。方法   应用实时荧光定量PCR（QPCR）和Western blotting检测80例喉癌组织及癌旁正常组织中的Klotho mRNA及蛋白表达情况,并探讨两者表达与临床病理特征的关系。采用甲基化特异性PCR（MSP）法检测Klotho基因启动子DNA甲基化状况。结果   80例喉癌组织中的Klotho mRNA 相对表达量为0.2890±0.012,低于癌旁正常组织的0.7908±0.015,差异有统计学意义（P＜0.01）;Klotho蛋白相对表达量为0.2290±0.009,低于癌旁正常组织的0.5368±0.023,差异有统计学意义（P＜0.01）。Klotho mRNA及蛋白表达与肿瘤浸润深度及淋巴结转移有关（P＜0.05）,而与年龄、性别、肿瘤部位、分化程度无关（P＞0.05）。喉癌组织及癌旁正常组织中Klotho基因启动子区DNA甲基化率分别为53.8％ （43／80） 、26.2％ （21／80）,差异有统计学意义（P＜0.05）。结论  Klotho基因在喉癌组织中表达下调,其表达可能受Klotho基因启动子区DNA甲基化水平的调控,且与浸润深度及淋巴结转移密切相关。     

185例孕妇TORCH系列病原体及人细小病毒B19感染的检测

目的　了解我区孕早期妇女弓形体、风疹病毒、巨细胞病毒、单纯疱疹 (TORCH)及人细小病毒B19的感染情况。方法　用ELISA法检测 185例孕早期妇女血清中特异性TORCH/HPVB19 IgM抗体。结果　感染率分别为弓形体 2 .2 % ,风疹病毒 1.6 % ,巨细胞病毒 1.6 % ,单纯疱疹病毒 1.1% ,人细小病毒B19(HPVB19) 8.1% ,其HPVB19 IgM抗体阳性率与TORCH各项相比 ,差异有极显著的统计学意义 (P <0 .0 1)。结论　我区孕妇中人细小病毒B19新近感染率明显高于其它TORCH各项病原体的新近感染率 ,有必要把HPVB19列入TORCH监测项目中 ,以提高妊娠质量     

叶天士＂通阳利小便＂法应用分析

从辨病性、病位、药性等不同角度分析叶天士治疗湿温病“通阳利小便”法的具体应用及其临床意义。     

Clinical characteristics associated with subcutaneous tophi formation in Chinese gout patients: a retrospective study

Clinical Rheumatology - The objective of this study is to analyze clinical characteristics associated with the formation of subcutaneous tophi among Chinese gout patients. It was a retrospective...