不同角膜屈光手术对基底膜下神经的影响

目的：观察角膜屈光不同术式后基底膜下神经恢复情况。
　　方法：角膜激光共焦显微镜观察术后1 mo 的 LASEK 12眼、LASIK 12眼、FLEx 12眼、SMILE 12眼,并对部分其它术后时段进行了对比观察。
　　结果：术后1 mo SMILE组基底膜下神经均未见明显破坏,走行规律,完整,切口处被切断神经对合良好;LASEK, LASIK和FLEx基底膜下神经仍现不同程度损害,其它时段眼显示随着时间推移,逐渐形成交通支。
　　结论：SMILE手术对基底膜下神经影响小,相对于其他几种角膜屈光手术,在术后神经恢复方面可能有一定优势。     

A novel method to prepare tussah/Bombyx mori silk fibroin-based films

The possibility of using silk fibroin in biomaterials for tissue engineering is a subject of broad interest. In this study, Bombyx mori/tussah silk fibroin (BSF/TSF) blend films were prepared by solution casting using CaCl₂/formic acid as a co-solvent and water as a rinse solvent. The morphology, crystallinity, thermal resistance, mechanical properties and water contact angle of the blend films as well as the biocompatibility were investigated. The BSF/TSF blend films displayed a smooth surface and specific nanostructure in their cross-section, originating from the nanofibril-preservation during fibroin dissolution. The water rinse process induced the formation of a stable β-sheet structure. The BSF film showed superior mechanical properties to the TSF film, and the blending with TSF led to a significant reduction in the strength and elasticity of blend films. However, adding the TSF component could regulate the hydrophilic properties and enhance cell growth on the blend films. The BSF/TSF blend films with specific nanostructure, stable secondary structure, appropriate mechanical properties, and good biocompatibility, are promising candidates for application in regenerative medicine.

A novel method is reported to prepare tussah/Bombyx mori silk fibroin blend films featured transparent, flexible and biocompatible.     

西安某高校研究生夜磨牙症现状调查

目的了解高校研究生夜磨牙症的发生情况及相关影响因素。方法选取西安交通大学2014年参加体检的1 944名研究生进行问卷调查和口腔检查,对检查结果进行统计学分析。结果高校研究生夜磨牙症发病率为14.0%;男生发病率为13.9%,女生发病率为14.2%,女生略高于男生,但差异无统计学意义。41.0%的被调查者称有室友患夜磨牙症,其中73.7%的人认为会影响晚上休息。熬夜、精神紧张、父母磨牙、颞颌关节紊乱为夜磨牙症的危险因素(P0.01)。结论高校研究生夜磨牙症发生率较高,对自身健康和同住人员均有影响,但就诊率较低。故学校应加强健康教育,预防和减少学生人群夜磨牙症的发生。     

Quantitative measurement of cartilage volume with automatic cartilage segmentation in knee osteoarthritis

Clinical Rheumatology - To determine the reproducibility of the automatic cartilage segmentation method using a prototype KneeCaP software (version 1.3; Siemens Healthcare, Erlangen, Germany) and...     

慢性难治性原发性免疫性血小板减少症治疗进展

原发性免疫性血小板减少症(Primary immune thrombocytopenia,ITP)原称特发性血小板减少性紫癜(Idiopathic thrombocytopenic purpura,ITP),是一种自身免疫性疾病,是由于机体免疫系统功能紊乱引起血小板破坏增多致其数目减少引起的出血性疾病,临床表现为皮肤黏膜瘀点、瘀斑,尿血,严重者可引起内脏和颅内出血危及生命,骨髓象表现为巨核细胞发育、成熟障碍。儿童急性ITP大多预后良好,75%~82%急性ITP 6个月内可获得缓解,持续6个月以上的ITP中超过1/4在     

Neutrophil extracellular traps and thrombosis in COVID-19

Journal of Thrombosis and Thrombolysis - Studies of patients with COVID-19 have demonstrated markedly dysregulated coagulation and a high risk of morbid arterial and venous thrombotic events....     

重症急性呼吸综合征患者中重症者早期预警指标研究

目的　探讨重症急性呼吸综合征 (SARS)患者中与重症发生相关的危险因素 ,寻找发生重症的早期预警指标。方法　对北京市SARS临床诊断病例数据库中转院资料完整 ,且在 2周内发生重症的 35 5例和始终未发生重症的 84 1例SARS患者进行单因素和多因素分析。结果　高龄、有基础病的患者发生重症的危险性明显增加。重症患者发生重症前表现出以下特点 :体温下降缓慢、脉搏加快、淋巴细胞计数持续 <0 9× 10 9/L、中性粒细胞高于 7 1× 10 9/L(80 % )、X线胸片异常进展较快等。采用Cox多元逐步回归发现 ,具有统计学显著性的早期预警重症发生的独立因素包括 :年龄偏大、有基础疾病、住院 2d后体温仍不能降至正常、住院 3d后中性粒细胞比值持续在 80 %以上、住院 4d后淋巴细胞计数仍持续 <0 9× 10 9/L和病程中出现脉搏持续加快达到 10 0次 /min。结论　根据SARS患者的年龄和基础病情况 ,结合临床对体温、脉搏、淋巴细胞绝对值以及中性粒细胞绝对值 (百分比 )的密切观察能够对重症SARS的发生进行早期预警。     

A fatal case of accidental oral formaldehyde poisoning and its pathomorphological characteristics

International Journal of Legal Medicine - Formaldehyde is a colourless irritating gas at room temperature, which, therefore, is usually stored in liquid form. This compound is often used as an...     

Survival rate,causes of death,and risk factors in systemic sclerosis: a large cohort study

To investigate the clinical pattern, survival rate, causes of death and risk factors in a large cohort of Chinese Han patients with systemic sclerosis (SSc). Inpatients treated from 2002 to 2014 were included in this study. Patients were classified into diffuse cutaneous SSc (dcSSc), limited cutaneous SSc (lcSSc), and SSc-overlap syndrome groups. Data were analyzed using Chi-squared tests, Kaplan–Meier curves, log-rank tests, and Cox proportional hazards modeling. Among a total of 201 patients, dcSSc (50.2%) was the major subtype, followed by lcSSc (30.3%) and SSc-overlap (19.4%). Interstitial lung disease (ILD, 148/201, 74%) was the most frequent organ involvement. The overall survival rates were 98% and 95% at 5 and 10 years, respectively. The overall standard mortality ratio (SMR) was 2.22. The most common cause of death was ILD combined with infection (8/16, 50%), followed by kidney failure (2/16, 12.5%). On crude analysis, pulmonary hypertension, ILD, cardiac involvements, renal involvements, and digital ischemia were associated with poor prognosis. On multivariate analysis, pericardial effusion (p?=?0.000) and digital ischemia (p?=?0.016) were independent prognostic factors of death. The mortality rate of patients with SSc is mildly increased in comparison with the general population. ILD is the most common systemic involvement and the principal cause of death in SSc. Pericardial effusion and digital ischemia are independent factors associated with death.