应用元情绪量表对士兵的情绪智力与个性特点研究

目的对士兵的情绪智力与人格特征进行对比研究,为制定个性化心理调控方案,改善士兵心理应付方式、提高其承受心理压力的能力及心身健康水平提供参考依据。方法应用元情绪量表(TMMS)和艾森克人格问卷(EPQ)对1080名士兵进行团体心理测试,将EPQ结果与地方成人常模进行比较,EPQ各因子分与TMMS总分及其分量表分做相关性检验。结果EPQ测试结果内外向(E)和神经质(N)维度均趋向正态分布,不同人格类型的士兵TMMS得分在E维度、N维度上差异均有显著性(P<0.05)。提示士兵大多数具有健康的个性特征,其情绪智力是与个性特征密切相关的。结论人格与情绪智力具有多纬度的相关性。     

2007年9～10月份杭州市大学生无偿献血分析

通过对9、10月份间杭州高校的无偿献血情况的分析,并以街头流动点的献血者作为对照,笔者发现高校大学生普遍对无偿献血有着积极态度,踊跃参加无偿献血.在这两个月间,此两类采血点共有14892例无偿献血者,其中高校学生5120例,占34.4%,是献血队伍中不可低估的力量.针对高校学生心理承受能力较差的特点,尤其是新生和初次献血者,心理疏导是重要的环节,采取防范措施,减轻献血后的不适反应,防止严重反应,确保在校大学生的安全,是有积极意义的.     

恙螨体内汉坦病毒核酸的基因芯片检测

目的 建立快速、灵敏、特异的汉坦病毒基因芯片诊断方法。方法 根据发表的汉坦病毒属(HV)76-118株和R22株S基因核苷酸序列，设计引物和探针，制备寡核苷酸芯片。用CV3标记核苷和引物，运用不对称PCR技术制备单链荧光标记核苷酸片段，并与芯片上的寡核苷酸探针杂交，荧光扫描仪检测并分析信号。结果 研究制备的基因芯片能够检测汉坦病毒HTN型和SEO型病毒核酸的特异性荧光信号。结论 HV的基因芯片检测具有特异、灵敏、快速的优点。基因芯片的制备和检测技术的建立，可为肾综合征出血热等传染病的诊断和预防提供理想的方法。     

恶性肿瘤并发皮肤瘙痒症5例临床分析

作者认为恶性肿瘤引起的瘙痒有二种特点:(1)患者难以忍受;(2)抗组织胺药物无效。     

The Storage Conditions of High-Fat Diet Are the Key Factors for Diet-Induced Obesity and Liver Damage

The diet-induced obesity (DIO) mouse model has been widely used for obesity studies. The effects of storage conditions on the composition of nutrients in high-fat diets (HFDs) and their impact on metabolic homeostasis have not been systemically investigated. In the current study, we tested the effects of HFDs stored under different conditions and found that mice fed a HFD stored in the fridge (HFD^fri) gained less weight than those fed HFDs stored in the freezer (HFD^fre). Further analysis revealed that changes in the relative abundance of medium-chain triglyceride (MCT) in the HFD^fri, which have much lower intestinal absorption rates, contributed to the body weight differences. In contrast, exacerbated liver damage and elevated levels of unfolded protein response (UPR) was observed in the mice fed by HFD^fri. Depletion of the UPR-regulated gene Nnmt alleviated liver damage via the inhibition of the integrated stress response (ISR). Our study, for the first time, provides evidence that HFD storage conditions can have a significant impact on both body weight changes and liver damage in the DIO model.     

我国高血压健康教育研究的现状分析

目的了解我国高血压健康教育领域研究现状和发展规律。方法利用中国生物医学文献数据库检索,获得1978-2006年我国高血压健康教育研究文献,并结合原文内容,分析我国高血压健康教育研究在年代、载文期刊、地域、发文机构、研究领域方面的分布特点。结果共检出高血压健康教育研究文献990篇。我国在该领域的研究工作始于1994年,2000年及以后发表论文占95.56%。载文量超过20篇的期刊有6种,刊载文献占17.68%。发表论文超过50篇的是医院、大学和疾病控制中心,发表论文占85.67%。在护理、治疗2个领域的研究占60.61%。结论我国在该领域的研究绝大部分研究集中在21世纪,且呈逐年上升趋势。医院承担着高血压健康教育研究的主要任务。研究主要集中在护理和治疗领域。但在预防领域研究不足。     

蚯蚓纤溶酶增加人食管癌细胞ECA109对放射线敏感性的实验研究

目的:探讨蚯蚓纤溶酶(EFE)对食管癌细胞的放射增敏作用及机制.方法:选取人食管癌细胞株ECA109,采用MTT法观察EFE对细胞的生长抑制作用,克隆形成实验观察EFE对细胞的放射增敏作用,流式细胞术观察EFE对细胞周期分布的影响,RT-PCR法检测EFE对细胞内硒谷胱甘肽过氧化物酶(SeGPx)mRNA表达的影响.结果:EFE对ECA109有生长抑制作用,其作用呈剂量依赖性,IC50为3.8 ukU·ml-1;EFE 0.1、0.3 ukU·ml-1的放射增敏比分别为1.37和1.59;EFE作用24 h后,食管癌细胞G2与M期比例明显下降,细胞内SeGPx基因表达明显下调.结论:EFE在体外可抑制ECA109的生长,同时可增加其对放射线的敏感性;放射增敏机制可能与EFE清除细胞G2/M期阻滞及下调细胞内抗氧化酶SeGPx mRNA表达有关.     

Initial satisfying experience of total retroperitoneal laparoscopic radical nephroureterectomy: a retrospective comparative research

BackgroundRadical nephroureterectomy (RNU) is the principal method for treatment of high-risk upper urinary tract urothelial carcinoma (UTUC). The transperitoneal approach is associated with poor disease progression, but the distal ureter-bladder cuff (DUBC) resection through retroperitoneal laparoscopic approach is difficult. This study proposed a modulated RNU technique, namely, total retroperitoneal laparoscopic radical nephroureterectomy (tRLRNU), with its advantages of DUBC resection and requiring fewer trocars etc. The efficiency, safety, and short-term impacts were retrospectively compared with total transperitoneal laparoscopic radical nephroureterectomy (tTLRNU).MethodsTotal of 12 patients who received tRLRNU and 28 patients who received tTLRNU were enrolled. The choice of surgical approach was random and their data were retrospectively analyzed. During tRLRNU, the laparoscope was versed towards the caudal direction and a retroperitoneal laparoscopic ureterectomy was performed. The bladder cuff was entirely transected and the bladder incision was sutured. The tRLRNU cases were compared with the tTLRNU cases in terms of general clinical data, pathologic parameters, peri-operative parameters, adjuvant therapy, and short-term outcomes. The independent samples t-tests, chi-square tests, and Fischer exact tests were used to analyze the differences.ResultsThere were no significant differences in the basic patient characteristics between the 2 groups. The data were comparable. There were significantly fewer trocars utilized in tRLRNU group compared to tTLRNU group (P=0.0008). tRLRNU group experienced less blood loss (98.33±61.32 versus 170.71±121.32 mL; P=0.017), smaller drainage volume (182.08±163.60 versus 1,924.82±3,370.02 mL; P=0.011), and shorter extubation time (5.67±1.07 versus 8.57±6.96 days; P=0.040) compared to tRLRNU group. There were no statistically differences in the other peri-operative parameters, including whole operation time, transfusion, visceral and vascular injuries, open conversion, post-operative bleeding, recovery time of intestinal function, and discharge time. The patient outcomes in tTLRNU group at 6 months were significantly worse than that of tRLRNU group by comparing progression-free survival, progression survival and mortality (P=0.039).ConclusionsThe tRLRNU was potentially safer, minimally invasive, and more effective compared to the tTLRNU. Due to the small sample size, short follow-up time and no randomization of the study, future comparative studies are warranted to further analyze long-term outcomes of tRLRNU.     

被动吸烟与肺癌的病例—对照研究

我们针对确定被动吸烟与肺癌关系设计了以医院人群为基础的病例对照研究.应用Mantel Haenssel方法及条件Logistic回归方法进行了单因素及多因素分析.结果表明:在研究对象家中有人吸烟、有1人吸烟、有2人吸烟,均发现与肺癌有显著意义的关联,OR值和95%CI分别为2.30,1.042～4.073、2.28,1.206～4.117、2.52,1.20～5.288;研究对象家中有1人在其出生前吸烟、其OR值为1.82,95%CI1.088～3.055,父亲吸烟及父亲在研究对象出生前吸烟其OR值与95%CI分别为2.13,1.179～3.858、2.28,1.275～4.061,同时我们还发现与吸烟的配偶生活20年以上者患肺癌的危险增加,OR值和95%CI为2.17,1.203～3.914;做饭年限超过25年,厨房与卧室相通者与肺癌间存在显著意义的关联.OR和95%CI分别为2.06,1.042～4.073、2.78,1.137～6.791.本研究未发现有统计学上显著意义的交互作用.有关母亲吸烟,服用维生素C,维生A,肺癌家族史及经济水平等因素均未发现在统计学上有显著意义的关联.     

认真防范中医医疗事故纠纷

<正> 我国传统医学受到宪法的保护,全国有众多从事中医工作的门诊部、医院、教学医院;在综合医院中还有中医科,理疗科也开展针灸按摩;另外还有中西医结合的门诊和医院,所以这部分医疗事故纠纷的防范,不仅对中医药事业的发展是有益的,而且也关系着广大群众的福祉。过去中医事故纠纷均依据《医疗事故处理办法》处理;今《医疗事故处理条例》颁布实施,可以理解,它已完全覆盖了这一方面,无须另立专条。就事故纠纷的性质、结果、处理而言中西医别无二致,但在专家鉴定中则不能不考虑中医的特殊性。因此在各级专家库中中医药专家是不可或缺,应当是同行评审才能显示公平,相信在实践过程中会得到合理解决。在防范中除抓好医德医风、健全医疗制度、提高医护人员素质、完善安全防范措施之外,建议同道特别注意三个问题。1 谨防误诊中医诊病传统的作法是靠四诊合参。一般,患者很少要