乳癌保留乳房手术的探讨

①目的 探讨乳癌保留乳房手术的可行性。②方法 将９０例Ⅰ,Ⅱ期乳癌病人随机分为两组,保留乳房手术组４２例,采用乳腺区段切除加腋窝淋巴结清扫术;改良根治术组４８例,采用乳腺全切加腋窝淋巴结清扫术,术后两组均行放疗、化疗和内分泌治疗。比较两组治疗效果及并发症发生情况。③结果 乳癌保留乳房手术组３年生存率为９５．２％,５年生存率为９１．７％,发生并发症４例,改良根治术组３年生存率为９５．８％,５年生存率     

医院物资管理与计算机网络

本文通过对医院物资管理特点的分析,总结出适用于医院的"三级分层体系"物资管理模式及办法,并对本院应用该模式建立的物资管理系统的工作原理、实现细节及特点作了较详尽的论述.     

降纤酶治疗青年人短暂性脑缺血发作的临床研究

目的 探讨降纤酶对青年人短暂性脑缺血（ＴＩＡ）发作的治疗效果。方法 将７２例患者随机分为两组。治疗组３７例,给予降纤酶静滴至ＴＩＡ发作终止或治疗达１周;对照组３５例,给予阿司匹林、尼莫地平、低分子右旋糖酐、脉络宁治疗２周。两组于治疗前、后分别采静脉血检测血浆纤维蛋白原、红细胞压积、全血粘度和血浆粘度的变化。结果 总有效率治疗组为９１．６６％,对照组为７７．１４％,２组间有显著性差异（Ｐ〈０．０１）     

消抗安胎口服液慢性毒性作用的实验研究

目的 观察消抗安胎口服液长期,大剂量使用对大鼠的慢性毒性作用。方法 血液生化分析法。结果 实验大鼠的整体状态,肝功能,肾功能,血糖等血液生化指标的测定及主要敏感脏器重量与对照组相比均无显著性差异。结论ＣＸＬ安全,无毒副作用,临床应用可靠。     

Optimal immobilization of penicillinase for lon-selective electrode

Penicillin sensor was prepared by immobilizing penicillinase (Pcase) on H⁺-selective carboxylated poly (vinyl chloride) (PVC-COOH) membrane or cellulose filter membrane. The immobilization techniques are as follows. Pcase was immobilized with GTH on H⁺-selective PVC-COOH membrane or some amount of BSA was dropped on that membrane. Another method to make immobilization is to mix type I Pcase with GTH and drop on a cellulose filter membrane. According to immobilization techniques, there were some differences in response properties of enzyme electrodes, however, all electrodes responded to Pcase-resistant penicillin derivatives. Pcase immobilized on cellulose filter membrane with H⁺-selective PVC membrane eletrode was more stable and more sensitive to penicillinase-resistant penicillin derivatives than any other immobilization techniques.     

Epimerization and Hydrolysis of Dalvastatin,a New Hydroxymethylglutaryl Coenzyme A (HMG-CoA) Reductase Inhibitor

In aqueous solutions, dalvastatin (1) undergoes epimerization as well as hydrolysis. The transformation of the drug was studied as a function of pH at 25°C in aqueous solutions containing 20% acetonitrile. At all pH values, first-order plots for the conversion are biphasic, indicating rapid equilibration of 1 with its epimer (2) and slower hydrolysis of 1 to the corresponding -hydroxy acid (3). Apparent first-order rate constants for the biexponential equation are given as a function of pH. The alkyl–oxygen cleavage of the lactone ring results in the epimerization of 1 to 2, whereas the acyl–oxygen cleavage results in the hydrolysis of 1 to 3. The epimerization is an S_N1 reaction reaching an equilibrium of [l] _eq/[2] _eq = 1.27. The epimerization rate is increased with an increase in the water content of the solvent. The hydrolysis of 1 to 3 is acid and base catalyzed. The hydrolysis is reversible in acidic media and irreversible in neutral and basic media. At pH values greater than 9, the hydrolysis reaction proceeds more rapidly than the epimerization.     

大鼠肝细胞线粒体三维结构的观察与重建

为深入研究大鼠肝细胞线粒体形态特征,本研究以钻石刀连续超薄切片,通过电子显微观察大鼠肝细胞线粒体的三维结构,对特殊形态的线粒体进行三维结构重组。结果表明：球形,椭球形,盘状及杆状等小型线粒体约占线粒体总数的５３．８％,而分枝形及各种不规则形的线粒体约占４１．６％。     

Kinetics study of palm oil hydrolysis using immobilized lipase Candida rugosa in packed bed reactor

Continuous hydrolysis of palm oil triglyceride in organic solvent using immobilized Candida rugosa on the Amberlite MB-1 as a source of immobilized lipase was studied in packed bed reactor. The enzymatic kinetics of hydrolysis reaction was studied by changing the substrate concentration, reaction temperature and residence time(tau) in the reactor. At 55 degrees C, the optimum water concentration was found to be 15 % weight per volume of solution (%w/v). The Michaelis-Menten kinetic model was used to obtain the reaction parameters, Km(app) and V max(app). The activation energies were found to be quite low indicating that the lipase-catalyzed process is controlled by diffusion of substrates. The Michaelis-Menten kinetic model was found to be suitable at low water concentration 10-15 %w/v of solution. At higher water concentration, substrate inhibition model was used for data analysis. Reactor operation was found to play an important role in the palm oil hydrolysis kinetic.     

True histiocytic lymphoma of the esophagus in an HIV-positive patient: an ultrastructural study

A 56-year-old white woman, seropositive for human immunodeficiency virus for 18 months without signs of acquired immunodeficiency syndrome, presented with retrosternal pain and progressive dysphagia secondary to an exophytic esophageal mass. Biopsies of the tumor showed a malignant neoplasm composed of pleomorphic, noncohesive cells growing in a diffuse, sheet-like fashion. Immunohistochemically, tumor cells were nonreactive with epithelial, lymphoid, neural, and monocyte/macrophage markers. Despite the noncontributory immunohistochemical findings, ultrastructural study of the tumor cells revealed convincing histiocytic features. Individual cells possessed long, slender filopodial projections, prominent Golgi apparatus, residual bodies, rare lysosomes, and prelysosomes. Immunoglobulin heavy chain and T-cell receptor gamma gene rearrangement studies detected no evidence of a clonal gene rearrangement. The patient responded poorly to chemotherapy and died 5 months after her initial symptom of dysphagia.     

住院病人焦虑的原因及护理对策

目的：分析住院病人焦虑的原因,有效地减轻住院病人的焦虑程度。方法：使用焦虑自评量表（SAS）及问卷对347例住院病人进行焦虑原因的调查分析。结果：问卷20题中有13项肯定组与否定组的SAS评分存在显著差异或非常显著差异;不同年龄、不同文化程度、不同住院时间、治疗费用不同支出方式的住院病人SAS评分也存在显著差异。结论：明确住院病人焦虑原因,可有针对性地对其做好心理护理。