Lasting Changes to Circulating Leukocytes in People with Mild SARS-CoV-2 Infections

Survivors of severe SARS-CoV-2 infections frequently suffer from a range of post-infection sequelae. Whether survivors of mild or asymptomatic infections can expect any long-term health consequences is not yet known. Herein we investigated lasting changes to soluble inflammatory factors and cellular immune phenotype and function in individuals who had recovered from mild SARS-CoV-2 infections (n = 22), compared to those that had recovered from other mild respiratory infections (n = 11). Individuals who had experienced mild SARS-CoV-2 infections had elevated levels of C-reactive protein 1–3 months after symptom onset, and changes in phenotype and function of circulating T-cells that were not apparent in individuals 6–9 months post-symptom onset. Markers of monocyte activation, and expression of adherence and chemokine receptors indicative of altered migratory capacity, were also higher at 1–3 months post-infection in individuals who had mild SARS-CoV-2, but these were no longer elevated by 6–9 months post-infection. Perhaps most surprisingly, significantly more T-cells could be activated by polyclonal stimulation in individuals who had recently experienced a mild SARS-CoV-2, infection compared to individuals with other recent respiratory infections. These data are indicative of prolonged immune activation and systemic inflammation that persists for at least three months after mild or asymptomatic SARS-CoV-2 infections.     

基于玻璃基底微流控芯片的制备

介绍一种基于玻璃基底微流控芯片的制作方法,通过光刻工艺在玻璃基底表面刻蚀出微通道。利用氧等离子体对聚二甲基硅氧烷（Polydimethylsiloxane,PDMs）和微通道所在的基底表面进行处理,使PDMS与基底表面性质由疏水性变为亲水性,完成PDMS与玻璃基底的共价键结合。通过实验表明,经氧等离子体处理之后的PDMS与玻璃基底的密封效果较好。鉴于PDMS具有良好的热稳定性,无毒性,以及较好的光学特性等,此微流控芯片可用于生物医学以及化学领域中的化学发光及荧光检测。     

阿魏酸钠治疗2型糖尿病合并脑梗塞50例

目的：观察阿魏酸钠治疗2型糖尿病合并脑梗塞的临床疗效。方法：符合2型糖尿病（2DM）合并脑梗塞诊断标准的患者85例随机分为治疗组50例和对照组35例,在常规治疗的基础上,治疗组加用阿魏酸钠0．3g／n静滴;对照组加用丹参注射液20ml／日静脉滴注,疗程均为14天。结果：治疗组有效率94％,对照组有效率74．3％。两组间疗效比较差异有显著性（P〈0．01）。结论：阿魏酸钠注射液治疗2型糖尿病合并脑梗塞具有良好的治疗效果,值得临床推广应用。     

Anelastic Behaviour of Commercial Die-Cast Magnesium Alloys: Effect of Temperature and Alloy Composition

The anelastic deformation, resulting from partial reversal of {101¯2} twinning, is studied at room temperature to 150 °C on several commercial die-cast magnesium alloys for the first time. The magnitude of anelastic strain decreases with increasing temperature. For inter-alloy comparison, AZ91 shows the largest maximum anelastic strain, while AM40 and AM60 show similar maximum anelastic strain. The phenomenon is discussed in terms of solid solution softening and hardening of slip planes and how they influence twinning. T5-aged AE44 consistently shows smaller magnitude of anelasticity compared to as-cast AE44, suggesting that the precipitates formed during ageing may decrease the twin-boundary mobility and further suppress untwinning. Presence of anelasticity poses a challenge to yield strength measurement using the conventional 0.2% offset method, and a more accurate and consistent method of using a higher offset strain or a lower modulus is proposed in this study.     

尿路清对临床耐药菌株Uu的药敏实验

目的：探索中药复方对Uu感染的非淋菌性尿道炎（NGU）的作用机理,从多角度为中医药治疗本病提供理论依据。方法：63个Uu临床分离株采用肉汤稀释法判定临床耐红霉素和四环素（MIC≥16μg／ml,参照美国国家临床实验室标准委员会1995年标准）;经三次传代成纯培养后接种于96孔板小孔中,药液倍比稀释成250mg／ml～0．48mg／ml,37℃培养,加药组以72h后仍不出现培养基由黄→红色变化的最小药物浓度为该药的最小抑菌浓度（MIC）。结果：尿路清对63株Uu临床株MIC范围为0．48mg／ml～15．36rag／ml,MIC50≤1．95mg／ml．MIC90≤3．91mg／ml,Uu临床株对尿路清的敏感性比对四环素的敏感性高的多（Х^2=18．38,P〈0．01）,Uu临床株对尿路清的敏感性与对红霉素的敏感性之间无明显联系（Х^2=1．85,P〈0．05）。结论：中药尿路清对63株耐药（四环素、红霉素）菌株Uu显示出了较强的体外抑菌作用,值得进一步研究。     

经桡动脉途径介入术后的桡动脉作为桥血管用于冠状动脉搭桥术可行性分析

目的评估经桡动脉途径介入术后的桡动脉作为桥血管应用于冠状动脉搭桥术(CABG)的可行性。方法回顾性分析168例应用桡动脉作为桥血管行CABG术患者的临床资料。根据使用是否经桡动脉途径介入术后的桡动脉作为桥血管,将168例患者分为介入组(76例)、非介入组(92例),比较两组患者的随访结果。结果两组患者临床资料比较无统计学差异(P0.05)。与介入组比较,非介入组桡动脉桥血管通畅率显著增高,心肌缺血事件发生率显著降低,差异有统计学意义(P0.05)。两组术侧前臂切口感染、拇指麻木、骨筋膜室综合征等桡动脉获取相关并发症发生率无显著差异(P0.05)。结论选择非经桡动脉途径介入术后的桡动脉作为桥血管可提高桥血管通畅率并改善CABG术的临床效果。