透明细胞乳头状肾细胞癌的影像学表现

目的 探讨透明细胞乳头状肾细胞癌(CCPRCC)的影像学表现.方法 分析15例CCPRCC患者CT及MRI影像特征,采用独立样本t检验比较肿瘤与肾皮质之间平扫CT值、ADC值差异.结果 15例均为单发,边界清晰,大小为(3.1±1.9) cm.13例为实性肿瘤,其中11例伴囊变,2例为囊性肿瘤.4例CT平扫呈等或稍低密...     

Mesenteric panniculitis does not confer an increased risk for cancers: A systematic review and meta-analysis

Background:Mesenteric panniculitis (MP) is a non-specific, localized inflammation at the mesentery of small intestines which often gets detected on computed tomography. An association with malignant neoplasms remains unclear. We performed a systematic review and meta-analysis to examine the association of malignancy with MP.Methods:MEDLINE, EMBASE, Web of Science, and Cochrane databases were searched for articles published from inception to 2020 that evaluated the association of malignant neoplasms with MP in comparison with control groups. Using random-effects method, a summary odds ratio (OR) estimate with 95% confidence intervals for malignant neoplasms in MP was estimated.Results:Four case-control studies reporting data on 415 MP patients against 1132 matched-controls met inclusion criteria and were analyzed. The pooled OR for finding a malignant neoplasm in patients with MP was 0.907 (95% CI: 0.688–1.196; P = .489). The heterogeneity was mild and non-significant. Also, there was no heightened risk of any specific type of malignancy with MP. Three more case-series with unmatched-control groups (MP: 282, unmatched-controls: 17,691) were included in a separate analysis where the pooled OR of finding a malignant neoplasm was 2.963 (95% CI: 1.434–6.121; P = .003). There was substantial heterogeneity in this group.Conclusion:This meta-analysis of matched controlled studies proves absence of any significant association of malignant neoplasms with MP. Our study also demonstrates that the putative association of malignancy with MP is mainly driven by uncontrolled studies or case-series.     

超选择子宫动脉栓塞治疗症状性子宫肌瘤的临床研究

目的:研究超选择性子宫动脉栓塞治疗子宫肌瘤的临床效果。方法:采用Seldinger法穿刺并超选择双侧子宫动脉PVA颗粒加明胶海绵栓塞治疗18例子宫肌瘤患者。结果:经双侧子宫动脉栓塞后6个月随访结果表明月经周期和经量恢复正常,疼痛和贫血等明显改善,肌瘤和子宫体积明显缩小。结论:超选择性子宫动脉栓塞治疗子宫肌瘤是一种创伤小、临床和社会效果好、安全、有效的新方法。     

乳腺癌术后患者心理社会适应水平调查研究

目的 探讨乳腺癌患者心理社会适应水平现状,并分析其与生活质量的相关性,为提高乳腺癌患者生活质量提供新的方向。方法 选取2020年9月至2021年6月新疆某三甲医院就诊的264例乳腺癌患者作为研究对象,采用一般资料调查问卷、乳腺癌心理社会适应问卷、乳腺癌患者生命质量问卷进行调查,分析乳腺癌患者心理社会适应水平与生活质量的相关性。结果 乳腺癌患者心理社会适应水平得分为(147.59±17.59)分,生活质量得分为(95.83±15.04)分;相关性分析结果显示,乳腺癌患者心理社会适应水平得分与生活质量总分呈正相关(r=0.379,P<0.001);多元分层回归结果显示,心理社会适应水平进入生活质量影响因素模型,心理社会适应水平可独立解释乳腺癌生活质量14.70%的变异。结论 乳腺癌患者疾病心理社会适应处于中低水平,且与生活质量呈正相关,疾病心理社会适应水平是其生活质量的重要预测因子。     

Dapagliflozin and measures of cardiovascular autonomic function in patients with type 2 diabetes (T2D)

AimsSodium-glucose cotransporter-2 (SGLT-2) inhibitors reduce blood pressure without compensatory heart rate elevation, possibly by modulating sympathetic/parasympathetic activity. This may contribute to their cardiovascular benefits in type 2 diabetes (T2D). We evaluated the effects of dapagliflozin (DAPA) on measures of cardiovascular autonomic neuropathy (CAN), cardiac function, and glucose variability (GV) in T2D.MethodsPilot, randomized, two-period crossover trial comparing 12-week DAPA versus 12-week glimepiride treatment on CAN measures (cardiovascular autonomic reflex tests and heart rate variability), B-type natriuretic peptide (BNP), and GV (Abbott's Libre Pro devices) using signed rank tests and mixed models from baseline to 12 weeks within and between each period.ResultsForty-five T2D participants on metformin monotherapy (mean age 57 ± 8 years, duration 7 ± 6 years, HbA1c 7.8 ± 1.3%) were enrolled with 41 completing the trial. There were no differences in CAN indices or BNP with each drug compared to baseline and each other. Participants on DAPA demonstrated greater weight loss, reduced time in hypoglycemia, and improved GV compared to glimepiride.ConclusionsShort term treatment with DAPA did not affect CAN measures or BNP in uncomplicated and relatively healthy T2D participants. Longer prospective studies in patients with advanced disease are needed to better understand relationships between SGLT-2 inhibitors and CAN.Clinical trial registration: NCT02973477     

A meta-analysis of the secondary fractures for osteoporotic vertebral compression fractures after percutaneous vertebroplasty

To identify the risk factors of the secondary fractures for osteoporotic vertebral compression fractures (OVCFs) after percutaneous vertebroplasty (PVP).We conducted a search of relevant articles using Cochrane Library, PubMed, Medline, Science Direct, Embase, the Web of Science and other databases. The time range we retrieved from establishment of the electronic database to November 2017. Gray studies were found in the references of included literature reports. STATA version 11.0 (Stata Corporation, College Station, Texas) was used to analyze the pooled data.Fourteen studies involving 1910 patients, 395 of whom had fracture secondary to the surgery were included in this meta-analysis. The result of meta-analyses showed the risk factors of the secondary fractures for OVCFs after PVP was related to bone mineral density (BMD) [95%CI (−0.650, −0.164), SMD=−0.407, P=.001], cement leakage ((RR=0.596, 95%CI (0.444,0.798), P = .001)), and kyphosis after primary operation ((SMD=0.741, 95%CI (0.449,1.032), P = .000)), but not to gender, age, body mass index, cement volume, thoracolumbar spine, and cement injection approaches.Bone mineral density, cement leakage, and kyphosis after primary operation are the risk factors closely correlative to the secondary fracture after PVP. There have not been enough evidences to support the association between the secondary fracture and gender, age, body mass index, cement volume, thoracolumbar spine, and cement injection approaches.     

Effect of the heme oxygenase gene on mycelial growth and polysaccharide synthesis in Ganoderma lucidum

The heme oxygenase gene has antioxidant and cytoprotective effects in organisms, but no related research has been conducted in Ganoderma lucidum. For the first time, we cloned the HMX1 gene in G. lucidum. The CDS is 1092 bp in length and encodes 363 amino acids. The HMX1 protein was prokaryotically expressed and purified, and the enzyme activity of the purified protein was measured. The value of K_m was 0.699 μM, and V_m was 81.9 nmol BV h⁻¹ nmol⁻¹ protein. By constructing the silencing vector pAN7-dual-HMX1i, the transformants HMX1i1 and HMX1i2 were obtained. Compared with the wild-type (WT), the average growth rate of HMX1i1 and HMX1i2 decreased by 31% and 23%, respectively, and the mycelium biomass decreased by 53% and 48%, respectively. Compared with the WT, the extracellular polysaccharide content of HMX1i1 and HMX1i2 increased by 59% and 51%, and the intracellular polysaccharide content increased by 24% and 22%, respectively. These results indicate that the HMX1 gene affects mycelial growth and polysaccharide synthesis in G. lucidum.     

门冬氨酸鸟氨酸(瑞甘)治疗慢性乙型肝炎36例

目的探讨瑞甘（门冬氨酸鸟氨酸）治疗慢性乙型肝炎（以下简称慢乙肝）的临床疗效。方法将66例慢乙肝病人随机分为两组,治疗组接受门冬氨酸鸟氨酸,对照组用门冬氨酸钾镁,均治疗4～6wk,观察病人治疗前后症状、体征、肝功能（TB,ALT,AST,r-GT）、HBVM（HBsAg、HBsAb、HBeAg、HBeAb、HBcAb）、HBVDNA。结果治疗结束时治疗组和对照组的有效率分别为94.4％和76．7％,有显著的统计学差异（P〈0．05）。结论门冬氨酸鸟氨酸对慢性乙型肝炎病人临床症状及肝功能有比较明显的改善作用;对血清HBVDNA阴转及血清HBVM转换效果不显著。