T follicular helper cells improve the response of patients with chronic hepatitis B to interferon by promoting HBsAb production

Journal of Gastroenterology - Hepatitis B surface antigen (HBsAg) seroconversion is considered the optimal outcome of the treatment of chronic hepatitis B virus (HBV) infection. In this study, we...     

Human in-stent restenosis tissue obtained by means of coronary atherectomy consists of an abundant proteoglycan matrix with a paucity of cell proliferation

Background In-stent restenosis (ISR) is a shortcoming of percutaneous coronary revascularization. Although neointimal cell proliferation is suspected to be the cause of this problem, little histological characterization of this tissue or data on cell replication exist. The purpose of this study was to examine the histologic features and proliferation profile of coronary ISR tissue derived from atherectomy procedures performed on patients with clinical evidence of ISR. Methods ISR tissue retrieved by means of atherectomy from 20 coronary lesions was subjected to histomorphological analyses and immunocytochemistry as a means of examining proteoglycan expression. Cell proliferation was assessed with 2 sensitive markers of replication, in situ hybridization for histone 3 messenger RNA expression and immunocytochemistry for Ki-67 expression. Results The ISR atherectomy specimens consisted primarily of smooth muscle cells, with occasional focal collections of inflammatory cells and organizing thrombus. All specimens had low levels of interstitial collagen and an abundant proteoglycan matrix, with biglycan being overexpressed more commonly than decorin. Cell proliferation was found in only 1 of 20 specimens (2 cells). Conclusion Established ISR lesions contained an abundant proteoglycan matrix and a paucity of proliferating cells. Future therapeutic strategies for ISR should include targeting extracellular matrix production. (Am Heart J 2002;144:702-9.)     

胃癌相关基因表达与其生物学行为关系研究

目的探讨P21、细胞周期素D1(CyclinD1)及P53基因表达与胃癌生物学行为的关系。方法应用原位杂交免疫组化技术检测74例胃癌组织及癌旁正常粘膜P21和CyclinD1mRNA及P53蛋白表达,分析三者与胃癌生物学行为的关系。结果74例胃癌组织和癌旁正常粘膜中,P21、CyclinD1及P53表达阳性率分别为43.2%和55.4%、40.5%和78.4%、25.7%和1.4%,三者比较均有显著性差异(P<0.01)。P21、CyclinD1及P53表达与患者性别、年龄、分期无明显相关性(P>0.05),与淋巴结转移显著相关(P<0.05);胃癌分化程度与P21阳性表达呈正相关,与CyclinD1阳性表达呈负相关。结论胃癌中P21低表达、CyclinD1和P53过表达可能促使胃癌细胞增殖,且具有更强的侵袭力;多基因表达异常可作为评价胃癌预后的重要参考指标。     

Effect of Information-Motivation-Behavioral Model Based on Protection Motivation Theory on the Psychological Resilience and Quality of Life of Patients with Type 2 DM

Psychiatric Quarterly - Diabetes mellitus (DM) is one of the remarkable disease challenges in the twenty-first century and poses threat to patients’ physical health. Given the difficulty of...     

融合多特征脑电评估孤独症儿童

孤独症是一种复杂的神经发育性脑疾病,其早期发现和精确诊断非常重要。从54名孤独症和50名正常儿童的脑电信号中提取功率谱、熵、双谱相干性以及相干性等多特征进行分析研究,并对每组特征进行独立样本t检验分析组间差异;为提高分类性能,提出融合多特征脑电进行分析,进一步采用最大相关最小冗余算法进行特征选择,最后利用支持向量机建立分类模型。结果显示,用单一特征分类,得到的分类准确率为72%,灵敏度为73.94%,特异性为67.74%,F1分数为69.74%,因此单一特征所建立的分类模型性能较差;在融合多特征进行分类时,选择前25个特征建立模型,具有较高的分类精度(93.45%±0.79%),此时灵敏度为91.73%±0.42%,特异性为94.01%±0.36%,F1分数为92.54%±0.31%,且AUC达到0.96,相比单一特征分类模型具有良好的性能。研究结果可以为孤独症的辅助诊断提供科学客观依据,为孤独症儿童后期康复提供可靠参考。     

集束化护理在胫腓骨骨折早期肿胀病人中的应用

目的:探讨集束化护理在胫腓骨骨折早期肿胀病人中的应用效果。方法:选取某医院2018年1月—2020年2月收治的80例胫腓骨骨折早期肿胀病人为研究对象,采用随机数字表法将病人分为对照组及观察组,每组40例,对照组采取常规护理,观察组采取集束化护理,比较两组病人的疼痛评分情况、骨折康复情况及并发症发生情况。结果:两组护理前后疼痛评分差异有统计学意义,且观察组疼痛评分下降幅度显著高于对照组(P<0.05);观察组康复有效率为85.00%,显著高于对照组65.00%(P<0.05);观察组并发症发生率为7.50%,显著低于对照组的22.50%(P<0.05)。结论:针对胫腓骨骨折早期肿胀病人,采用集束化护理能有效改善病人疼痛,减少并发症,取得良好的康复效果。     

Three-dimensional position of mandibular third molars and its association with distal caries in mandibular second molars: a cone beam computed tomographic study

Clinical Oral Investigations - To analyze the prevalence of distal caries in mandibular second molars (M2Ms) and its correlation with the three-dimensional position of mandibular third molars...