不同方法治疗特殊部位白癜风疗效的比较

目的通过不同方法治疗特殊部位白癜风的疗效观察,以便筛选出对不同部位白癜风的最佳治疗方法.方法随机将l 22例(375区白斑)特殊部位白癜风患者分为5组,移植微型毛胚组42例,磨削去除白斑组52例,毛囊刮取物注射组35例,液氮冷冻起疱去除白斑组30例,外用药物治疗组45例.观察其疗效,对各组病例统一疗效标准判断,统计学处理.结果移植微型毛胚组总有效率97.1 %,磨削去除白斑组总有效率94.7 %,毛囊刮取物注射组总有效率59.7 %,液氮冷冻起疱去除白斑组总有效率57.1%,外用药物治疗组总有效率45.5 %.经统计学处理,各组之间比较,差异有非常显著性意义(χ^2＝111.77,P＜0.005).结论特殊部位白癜风的治疗,目前仍是一个棘手的问题,上述所介绍的方法无疑是在实践中切实可行的方法,各有特色,可以根据不同部位,酌情选择最佳方法,也可以联合应用,相互补充,提高疗效.     

FcγR在口腔疾病中的临床意义

IgG Fc功能区的受体（FcγR）在联系细胞免疫和体液免疫方面有其重要作用。体内多种细胞表面可表达IgG Fc受体，并通过与免疫复合物的结合参与IgG介导的生理或病理过程，调节免疫反应。本文就近年来FcγR的生化特征和在口腔疾病中临床意义的研究进展作一综述。     

穹窿体与肿瘤多药耐药

穹窿体是真核细胞中的核糖核蛋白颗粒,由肺耐药蛋白、穹窿体多聚腺苷二磷酸聚合酶、端粒酶相关蛋白和穹窿体RNA构成,其主要成分为肺耐药蛋白。肺耐药蛋白是介导肿瘤多药耐药的蛋白之一,可能与肿瘤的治疗效果和临床预后相关。穹窿体可能通过介导药物转运或者信号转导引起肿瘤的多药耐药。文章介绍了穹窿体的结构、成分及其介导多药耐药机制研究的新进展。     

少突胶质与早产儿脑室周围白质软化

脑室周围白质软化是早产儿最主要的脑损伤类型,少突胶质前体细胞(OPC)是病变的关键靶细胞,OPC对缺血缺氧和炎症反应引起的损害高度敏感.了解OPC的易损机制可为防治脑窒周周白质软化提供新的思路.     

掌背动脉逆行岛状皮瓣修复多指皮肤缺损

目的报道应用掌背动脉逆行岛状皮瓣修复多手指软组织缺损的方法。方法应用掌背动脉逆行岛状皮瓣修复手指软组织缺损16例38指。结果术后16例38块皮瓣全部存活。随访时间为4个月～1年，皮瓣外形优良，不臃肿，皮瓣两点分辨觉为5～9mm。供区植皮成活，掌背有环形瘢痕，少许色素沉着。结论掌背动脉逆行岛状皮瓣操作方便，易切取，损伤小，不牺牲主干动脉，手术可同时切取多块皮瓣修复多指软组织缺损，是修复多手指皮肤软组织缺损的良好方法。     

颞颌关节继发性滑膜炎的临床诊断

颞颌关节滑膜炎分为原发性和继发性两种，颞颌关节紊乱综合症的滑膜炎为继发性滑膜炎。本文通过对１０６例颞颌关节紊乱综合症患者的临床检查、关节许氏位以及关节上腔造影的Ｘ线检查，同时对４２例进行了关节内窥镜检查，在此基础上探讨了继发性滑膜炎的临床诊断标准．作者认为急性滑膜炎主要是以关节疼痛和滑膜血管的改变为主，慢性滑膜炎的临床症状与滑膜组织改变以及关节骨组织的改变均有关系。     

胆道支撑管显影材料的制备及体外细胞毒性评价

目的 探讨新型显影胆道支撑管材料制备的可行性，对构建出的材料进行体外细胞毒性评价和筛选。方法 选择具有X线下显影特性的基础材料A、B、C，分别与硅橡胶生胶共混炼，模压后分别得到相应的显影复合材料甲、乙、丙，经一段和二段硫化过程完成加工。采用MTT法作为体外细胞毒性评价的方法，测定参比对照材料和新材料的50％浓度的浸提液对小鼠成纤维细胞的增殖率的影响，确定细胞毒性级别。结果 新材料甲、乙、丙在x线下影像清晰。甲、乙材料的细胞毒性级别为零，丙材料细胞毒性级别为2。结论 构建出在X线下显影的弹性体材料可行。材料甲、乙是制造新型胆道支撑管的初选材料，材料丙无应用的价值。     

Changes in the position of the mental foramen as a result of alveolar atrophy

summary The location of the mental foramen has often been claimed to be unaffected by alveolar atrophy. In the present study, the distances of the mental foramen and the mandibular canal from the lower cortex of the mandible were compared in a radiographed series of 40 edentulous elderly women with advanced alveolar atrophy and 40 elderly women who had 10 or more lower teeth left. The mental foramen was situated on average 3.8 mm lower in dentulous jaws than in dentulous jaws (P<0.0001). The mandibular canal was also situated lower in edentulous jaws, but the difference was not statistically significant. The results confirm the finding that the mental foramen seems to descend as a result of alveolar atrophy.     

cis-Acting packaging motifs of porcine adenovirus type 3

The cis-acting packaging domain is required for selective encapsidation of adenovirus DNA into preformed empty capsids late in the viral life cycle. Earlier, it was demonstrated that the cis-acting packaging domain of porcine adenovirus type (PAdV)-3 is located between nucleotide position (nt) 212 and 531 at the left end genome which contains six AT/GC rich motifs. Removal of packaging domain from left end to the right end of the genome produced a viable mutant virus suggesting that the identified cis-acting packaging domain represents the DNA sequences required for selective packaging of PAdV-3 DNA, whose position and orientation appear to be flexible. Here, by constructing and analyzing a panel of virus mutants carrying deletions or linker scanning mutations in AT/GC rich sequences, we examined the significance of the continuous A/T or G/C sequences individually in the viral packaging process. In contrast to consensus bipartite structure (5'-TTTGN8CG-3') described for most of packaging motifs of human adenovirus type 5 (HAdV-5), the packaging motifs I, II, III, and IV of PAdV-3 displayed a tripartite structure in which the continuous A/T nucleotides were flanked by G/C-rich sequences. Mutations in both continuous A/T nucleotides and its flanking GC-rich sequences reduced the packaging efficiency of mutants to varying degrees. In addition, although the continuous A/T sequences were present in all of the packaging motifs, their significance in the packaging process appears to vary within each packaging motif.