米非司酮固体脂质纳米粒的性状研究

制备并考察了米非司酮固体脂质纳米粒(SLN).结果表明,所得制品呈圆球状,粒径较均匀;x射线衍射分析表明SLN中米非司酮主要以无定形结构为主;差示扫描量热法结果表明,在较高药脂比时,SLN分散系中的药物仍以高分散状态存在.     

补肾活血法对子宫内膜异位症不孕患者基础体温的影响

目的:探讨补肾活血法对子宫内膜异位症不孕患者基础体温的影响。方法:将45例内异症不孕患者按2∶1随机分为中药治疗组和西药内美通对照组,经过6个月经周期的治疗后比较两组基础体温的变化。结果:治疗组在治疗前后黄体时间的高低温差呈增加趋势,体温上升时间及黄体期体温波动呈下降趋势;对照组在治疗前后黄体时间、高低温差、体温上升时间和黄体期体温波动无显著差异。结论:补肾活血法治疗内异症不孕,能影响基础体温,提示中药对卵巢功能有调整作用。     

Association between interleukin-10 genetic polymorphisms and risk of primary open angle glaucoma in a Chinese Han population: a case-control study

AIM: To investigate the association between interleukin-10 (IL-10) genetic polymorphisms and risk of POAG through a case-control study in a Han population of China. METHODS: A total of 210 patients with POAG and 420 normal subjects were recruited during the period from Dec. 2013 to Dec. 2016. The IL-10 -1082A>G (rs1800870), -819T>C (rs1800871) and -592C>A (rs1800872) polymorphisms were determined using iPlex GOLD SNP genotyping analysis (the SequenomMassARRAY® System, Sequenom, San Diego, USA). The association between IL-10 -1082A>G (rs1800870), -819T>C (rs1800871), and -592C>A (rs1800872) polymorphisms and risk of POAG was assessed by singlelogistic regression analysis. RESULTS: We observed that those carrying the CC genotype of rs1800871 was associated with an increased risk of POAG when compared with those harboring the TT genotype (OR=1.84, 95%CI=1.01-3.38). Those with AA genotype of rs1800872 had a 10.62 fold risk of POAG in comparison to the CC genotype (OR=10.62, 95%CI, 3.41-33.09). A completely linkage disequilibrium was found between IL-10 rs1800871-rs1800872 (D’=1.00, r2=0.16). The A-C-A (OR=2.60, 95%CI, 1.48-4.58) and G-T-A (OR=2.34, 95%CI, 1.42-3.86) haplotypes were associated with an increased risk of POAG, while the A-T-C haplotype showed a decreased risk of POAG (OR=0.63, 95%CI, 0.49-0.81). CONCLUSION: Our data suggest that IL-10 rs1800871 and rs1800872 can be predictive factors for the pathogenesis of POAG in the Chinese population.     

改良可视双腔支气管导管塑形方法在胸科手术单肺通气中的应用

目的 观察改良可视双腔支气管导管（Visual Double-Lumen Tube,VDLT）塑形方法在胸外科手术单肺通气中的应用效果。方法 选取2020-08至2021-08我院胸外科择期手术单肺通气患者60例,美国麻醉医师协会（American Society of Anesthesiologists,ASA）分级I～Ⅲ级,年龄24～80岁,性别不限,BMI 19～28 kg/m2。采用随机数字表法将患者分为传统塑形组（Tsaditional Shaping,TS组）和改良塑形组（Isproved Shaping,IS组）,每组30例。记录麻醉诱导前（T1）、麻醉诱导后即刻（T2）、插管后1 min(T3)的心率（Heart Rate,HR）及平均动脉血压（Mean Arterial Pressure,MAP）;记录插管时间、插管次数、支气管定位情况;记录术后咽喉部疼痛、声音嘶哑等并发症情况。结果 TS组插管时间（67.1±23.8）s明显长于IS组（38.9±10.0）s;TS组插管次数1.3±0.4次明显多于IS组1.0±0.0次（P<0.05）,两组可视双腔支气管导管支...     

股骨颈骨折空心加压螺钉内固定手术前后的护理

空心加压螺钉内固定治疗股骨颈骨折具有切口小、创伤小、不需要特殊设备而又经济的优点,但其固定牵引度相对来说较低,所以做好手术前后的护理尤为重要.对此,笔者在长期的临床实践中积累了一定的护理经验,现介绍如下.     

基于探索性因子分析的医学类院校新入职教师胜任力模型构建研究

目的　分析医学类院校新入职教师胜任能力要素并构建胜任力模型。方法　通过文献研究法、半结构化访谈法、专家咨询法,编制医学类院校新入职教师胜任力调查问卷,对12所医学类院校的新入职教师进行问卷调查。运用主成分分析法提取因子。结果　问卷的Cronbach’s α系数为0.95。医学类院校新入职教师胜任力模型包括6个因子：科研水平（38.282%）、教学能力（10.118%）、职业道德（7.150%）、沟通能力（5.707%）、个人特质（4.707%）、自我完善能力（4.218%）。结论　构建医学类院校新入职教师胜任力模型,以期对新入职教师岗前培训模式的优化和相关政策的研究有所帮助。     

应用锁骨钩钢板治疗Tossy Ⅲ型肩锁关节脱位

目的探讨锁骨钩钢板治疗TossyⅢ型肩锁关节脱位的临床疗效。方法我们对2003年2月～2007年1月间52例TossyⅢ型肩锁关节脱位的患者均采用锁骨钩钢板复位内固定治疗。所有患者均未进行喙锁韧带缝合修复,但缝合损伤的肩锁关节囊及韧带和三角肌、斜方肌附丽。6～9个月后取出内固定。按Lazzcano法评定肩关节功能。结果52例患者得到随访,随访9～12个月,平均10个月。肩关节功能,取内固定前:优40例,良10例,差2例,优良率96%;取内固定后:优45例,良7例,差0例,优良率100%。肩关节功能取内固定前为良或差的病例在取出内固定后均有不同程度的改善。无切口感染、内固定松脱或断裂及再脱位等并发症。结论锁骨钩钢板是治疗TossyⅢ型肩锁关节脱位的最好治疗方法,具有操作简单,手术时间短,创伤小,可保证百分百复位,固定可靠,符合肩锁关节的生物力学要求,术后可早期功能锻炼,功能恢复好等特点。     

Catastrophic Periprosthetic Osteolysis in Total Hip Arthroplasty at 20 Years: A Case Report and Literature Review

BackgroundPeriprosthetic osteolysis is a serious complication following total hip arthroplasty (THA). However, most orthopedic surgeons only focus on bone loss and hip reconstruction. Thus, it was required to understand the treatment algorithm for periprosthetic osteolysis integrally.Case PresentationA 52‐year‐old Asian male presented with chronic hip pain. A mass appeared on the medial side of the proximal left thigh at more than 20 years after bilateral THA. Radiographs revealed catastrophic periprosthetic osteolysis, especially on the acetabular side. Large amounts of necrotic tissue and bloody fluids were thoroughly debrided during revision THA. A modular hemipelvic prosthesis was used for revision of the left hip. Four years later, the patient presented with right hip pain, where a mass appeared on the medial side of the proximal right thigh. A primary acetabular implant with augment was used for revision of the right hip. Laboratory evaluation of bloody fluid retrieved from surgery revealed elevated levels of inflammatory markers.ConclusionInflammatory responses to polyethylene wear debris can lead to severe bone resorption and aseptic loosening in the long‐term following THA. Therefore, in spite of revision THA, interrupting the cascade inflammatory might be the treatment principle for periprosthetic osteolysis.