Clinical report of cervical arthroplasty in management of spondylotic myelopathy in Chinese

Objectives  

To investigate clinical effects and manual operational point of Bryan cervical disc prosthesis in Chinese, to observe the stability and range of movement (ROM) post-operatively.     

Arterial effects of salt restriction in hypertensive patients. A 9-week, randomized, double-blind, crossover study.

OBJECTIVE: To investigate the hemodynamic effects of a moderately low-salt diet in a 9-week, randomized, double-blind, crossover study in 20 hypertensive, ambulatory patients. METHODS: All subjects followed a 9-week, low-salt diet. During this period, they received capsules containing either lactose or salt in 4-week treatment periods, separated by a 1-week washout period. Hemodynamic and biological parameters were evaluated on the day of randomization and at the end of weeks 4 and 9. We defined a low-sodium diet (LSD) as a salt-restriction period with lactose capsules, and a normal-sodium diet (NSD) as a salt-restriction period with capsular salt supplementation. RESULTS: Blood pressure was significantly lower during LSD compared with NSD. This fall in blood pressure was associated with a decrease in peripheral resistance in carotid and forearm circulation. Brachial artery diameter was larger during LSD whereas carotid artery diameter remained unchanged. The changes in brachial artery were: (1) not related to blood pressure changes; (2) positively related to age, and (3) negatively correlated with baseline intracellular sodium content. CONCLUSIONS: These results suggest that moderate low-salt restriction is capable of decreasing blood pressure and peripheral resistance in carotid and forearm circulation. The increase in brachial, but not carotid, artery diameter following salt restriction suggests a difference in salt dependence among different arteries.     

传染病研究40年（1955～1995年）

本文综述本校传染病学教研室１９５５～１９９５年间所取得的科研成果。内容包括１０余种传染病与寄生虫病的临床和基础研究，其中以华支睾吸虫病、恙虫病等有广东特色的传染病以及伤寒、痢疾、病毒性肝炎等影响人民健康最普遍的传染病为重点。反映了建国以来各个时期本教研室对防治这些传染病所作的贡献。所取得的成果，相当一部分通过多年来的验证，已获得广大传染病工作者所认同或列为常规，部分已获得部委级奖励。现在重温这些成果，可能起承前启后的意义。     

基因芯片快速HLA-DR52组分型

目的 用基因芯片对HLA-DR52组快速分型。方法 根据中国汉族人群常见的HLA-DRB位点及其基因多态性的独特序列，设计特异性的寡核苷酸分型探针，制成寡核苷酸芯片。通过组间特异引物扩增基因组DNA，扩增中用荧光标记，扩增标记后的产物与芯片的探针杂交，通过杂交产生的荧光信号确定样品的基因亚型。83份样本分别用基因分型芯片和序列特异性引物聚合酶链反应技术(PCR-SSP)对HLA-DR52组分型。结果PCR-SSP分型DR52组57个位点中，经芯片分型有2个无DR52组位点，3个PCR-SSP分型为DR52组纯合子，芯片为DR52组杂合子，1个PCR-SSP分型为非DR52组纯合子，芯片分型为含有1个DR52组位点的杂合子。结论 基因芯片能对HLA-DR52组快速、准确的分型，比PCR-SSP能更多的检出DR52组位点，特别是能将纯合子进一步分型，适合临床应用。     

环氧合酶-2和血管内皮生长因子共表达与肝细胞癌血管形成的关系

目的　探讨环氧合酶 (COX) 2与肝细胞癌血管形成的关系。方法　利用免疫组织化学、Westernblot方法检测 48例肝癌组织中COX 2和血管内皮生长因子 (VEGF)蛋白及逆转录 聚合酶链反应法 (RT PCR)检测COX 2和VEGFmRNA的共表达 ,对共表达COX 2和VEGF蛋白和mRNA的肝癌组织进行微血管记数。结果　免疫组织化学检测中 ,48例肝癌组织 3 6例共表达COX 2和VEGF蛋白。类似结果见于蛋白电泳分析。RT PCR显示 ,48例肝癌组织 3 6例共表达COX 2mRNA和VEGFmRNA。两者之间的表达明显相关 (γ =0 .845 )。共表达COX 2和VEGF蛋白和mRNA的肝癌组织中 ,平均微血管数 (5 6.8± 17.5 )个 ,明显高于阴性表达组。结论　COX 2可能与肝细胞癌的血管形成有关 ,且其作用之一可能是通过上调VEGF通道来发挥的     

水蛭注射液对大白鼠血小板粘附和血小板聚集功能的影响

目的　探讨水蛭注射液对大白鼠血小板粘附性和聚集性的影响。方法　采用大白鼠 2 4只 ,随机分成两组 ,实验组给药 ,对照组以实验组同样的方法和剂量给予生理盐水 ,5d后由颈总动脉取血 ,做血小板粘附性和聚集性试验。结果　水蛭注射液对大鼠血小板粘附性和聚集性具有显著的抑制作用 ,实验组与对照组抑制率有显著的统计学意义 (P <0 0 0 1)。结论　水蛭注射液能够抑制大白鼠血小板的粘附和聚集。     

烧伤感染的现状、对策与防治新动向

1 烧伤感染的现状2006年6月在昆山召开的第四届全国烧伤救治专题研讨会上,不同地区的烧伤中心或单位提供的微生物学调查资料中有不少共同点,其中很主要的一点就是:铜绿假单胞菌和金黄色葡萄球菌仍是烧伤检出菌中的主要细菌,也是我国近50年来大面积深度烧伤救治工作中难以清除的病原菌,不变中的变化是其耐药性不断增长。甲氧西林耐药金黄色葡萄球菌因被专门命名,人们对其认识较深刻,而革兰阴性杆菌耐药性的快速增长也不容忽视。革兰阴性杆菌对许多抗生素已由多重耐药性逐步发展为全耐药性;而且在多种新型抗生素的压力下,又筛选、激活了一些此前未被注意的机会致病菌。当前应特别注意的是鲍氏不动杆菌和嗜麦芽窄食单胞菌,它们正逐步成为医院感染的重要细菌。上述细菌毒力并非特别强,只因其存在天然耐药性,一旦过度繁殖,可能成为"无药可治"的难治菌。在此有必要强调,"医院感染"的含义是"患者住院后获得新的感     

Foreign metallic pellet in the heart

Foreign bodies in the heart are a rare but serious form of cardiac injury. The objects usually are sharp pointed. Such as acupuncture needles,sewing needles, coat hangers, fragments of Kirschner wires, pins, etc. 1 We report a patient with a metallic pellet lodged in the heart, which was accurately diagnosed and successfully removed.     

血小板活化与冠心病关系的研究进展

病理性血小板活化与血栓性疾病密切相关,在心血管疾病中,这一病理生理过程不仅与冠心病的发生、发展有着非常重要的联系,而且对于该病的治疗策略的优化和近、远期预后等方面都有直接的影响。