Carcinoma in Situ of the Cervix

Carcinoma in situ is not always cured (even though it could be) because of errors in morphological diagnosis and inadequate operative techniques. In the past we have been conditioned to accept the tissue biopsy diagnosis in preference to the cytological diagnosis. In many cases positive exfoliative cytology has not been explained by tissue biopsy, mainly because the technique of tissue sampling has been inadequate. Insufficient operative techniques have failed to remove sufficient vaginal vault adjacent to the cervix. Failure to recognize that these early lesions may spread to the vaginal vault has resulted in a recurrence to the vaginal apex, either as a carcinoma in situ or an early invasive carcinoma. Because of the multicentricity of carcinoma in situ, cancerization of the entire female genital tract may occur. It is therefore mandatory that all patients be followed up with cytology after any method of management.     

Influence of the duration of experimental fever on salicylate antipyresis in the rabbit

1. Steady state fever has been produced in rabbits with a priming injection followed by a sustaining infusion of homologous plasma containing endogenous pyrogen (EP). This fever appears to last as long as the infusion continues.2. Intravenous salicylate given 1 h after the start of the EP infusion produced only a small antipyretic effect. The same dose of salicylate given 4 h after the start of an EP infusion resulted in rapid and progressive defervescence. Intermediate antipyretic responses were obtained when salicylate was administered intravenously 2 and 3 h after the start of an EP infusion.3. Less than 1% of the systemic dose, when injected into a lateral cerebral ventricle, produced a significantly smaller response at 1 h than at 4 h after the start of an EP infusion. At both these times the fall in temperature following the intraventricular salicylate injection was dose dependent, but the slope of the dose-response line was significantly steeper at 4 h than at 1 hour.4. It is suggested that salicylates produce their antipyretic effects by antagonizing the action of EP within the nervous system, and that the hypothalamic EP concentration falls during the course of an EP infusion.