复方积雪草有效组分对人肾小管上皮细胞补体C3表达的影响

目的：探讨复方积雪草有效组分——积雪草苷／大黄素干预肿瘤坏死因子-α（TNF-α）诱导的人肾近曲小管上皮细胞（HPTEC）补体C3 mRNA及蛋白的表达水平。方法：采用HPTEC，模型组TNF-α 10ng／ml诱导，治疗组在TNF-α诱导的同时，以不同浓度的积雪草苷、大黄素以及积雪草苷合大黄素进行干预，于24h后分别提取细胞RNA及上清，应用逆转录-聚合酶链反应（RT—PCR）和酶链免疫方法（ELISA）分别检测HPTEC C3 mRNA和蛋白的表达。结果：正常HPTEC具有C3 mRNA和蛋白表达，经TNF-α诱导后G表达明显上调，用不同浓度的积雪草苷、大黄素以及积雪草苷合大黄素干预后，C3 mRNA及蛋白水平表达出现不同程度的下调，呈一定的剂量依赖关系和协同作用。结论：复方积雪草有效组分能够抑制炎性细胞因子TNF-α上调所致的肾局部G过度产生。     

Advances in Magnetic Resonance Imaging for the assessment of degenerative disc disease of the lumbar spine

The intervertebral disc is characterized by a tension-resisting annulus fibrosus, and a compression-resisting nucleus pulposus composed largely of proteoglycan. Both the annulus and the nucleus function in concert to provide the disc with mechanical stability. Early disc degeneration begins in the nucleus with proteoglycan depletion. Quantitative MRI techniques have been developed to non-invasively quantify the earliest degenerative changes that occur within the disc. Our ability to identify and quantify these early biochemical changes will provide a better understanding of the pathophysiology of disc degeneration and facilitate the study of interventions that aim to halt or reverse the degenerative process.     

真菌感染致膀胱挛缩1例

患者，男，65岁。2001年4月因左肾鹿角状结石在外院行左肾盂切开取石术。术后3月拔D—J管后出现尿频、尿痛等尿路刺激症状，每日排尿10余次，左下腹持续性钝痛。经抗感染治疗、呋喃西林冲洗膀胱，好转，膀胱容量约200ml。此后症状反复发作。2002年5月尿培养发现有念珠菌生长，服用氟康唑与小苏打片，     

老年人绞窄性肠梗阻86例外科治疗体会

绞窄性肠梗阻是老年外科的一种严重急腹症,早期诊断困难,病死率高,我院外科自1979年至1992年6月经手术治疗老年人绞窄性肠梗阻86例。占同期绞窄性肠梗阻212例的40.6％;占同期老年人肠梗阻192例的     

Ultrasound Biomicroscopic Dark Room Provocative Test

Purpose : To compare the clinical application value of Ultrasound biomicrsocpic dark room provocative test with the traditional dark room test in screening primary angle closure glaucoma (PACG).Methods: 22 eyes with PACG in prodromal stage and 30 eyes with deep anterior chamber and wide angle of 15 normal persons were observed in this trail. All 52 eyes were performed traditional dark room provocative test and ultrasound biomicorosopic darkroom test respectively. With different positive diagnostic criteria, the sensitivity of the two methods were compared using chi-squared analysis.Results : After staying in the dark room for 2 hours, In case group, IOP in 10 of 22 eyes rose more than 1. 07kPa(1kPa = 7.5mmHg), in 12 eyes less than 1.07kPa or had no changes; appositional angle closure were found by Goldmann gonioscopy in 8 eyes : 3 eyes in two quadrants, 5 eyes in more than two quadrants; the appositional angle closure was found by UBM in 15 eyes; 3 eyes in one quadrants, 5 eyes in two quadrants, 7 eyes     

药膜喷雾按摩治疗面部痤疮的临床观察

药膜喷雾按摩治疗面部痤疮的临床观察５５０００２贵州省贵阳市第四人民医院张健５７２０００海南省农垦卫校门诊部王永痤疮是青春期的一种常见病、多发病。我科于１９９５年以来采用自制苦参、黄芪等中药药膜喷雾按摩治疗面部痤疮１０８例。均收到满意效果，现报告如下。...     

Ultrastructural Observations of The Anterior Chamber Angle Tissues in Congenital Glaucoma

Eighteen trabeculectomy specimens of congenital glaucoma were examined by light and transimssion electron microscopy. The results showed that the primary anomalies in congenital glaucoma included the developmental defects of trabecular meshwork, excessive collagen fibrils in the trabecular matrix, shifting forward of ciliary muscle fibres and persistent mesenchymal tissues in the anterior-chamber angle. The authors also pointed out the importance of the secondary lesions of the trabecular meshwork in the pathogenesis of congenital glaucoma. Eye Science 1994; 10:50-56.     

游离骨膜移植修复关节软骨缺损的实验研究

在家兔的股骨内髁上作一关节软骨全层缺损,且从同侧胫骨近端取下一片骨膜骨块,将骨膜生发层向外包绕骨块,嵌入缺损处,观察其作用。实验表明,骨膜在一定条件下可以化生成软骨;滑液环境与关节运动在软骨化生过程中起重要作用;透明软骨化生和再生率与运动量及开始时间相关;自体骨可作为一种将游离骨膜固定在软骨缺损内的填充材料。     

快速自凝双丙烯酸树脂在临时性冠桥中的应用

固定修复是目前深受广大牙体缺损及牙列缺损患者满意的修复方法之一.在固定修复的过程中,基牙预备后、永久性修复完成之前,暂时冠桥起着非常重要的作用.它既避免对颌牙伸长又防止牙龈的增生.40多年来,甲基丙烯酸树脂由于其具有质轻、制作容易、价廉等优点,曾一度普遍用于暂时冠桥的制作,但由于其在制作及患者使用过程中的一些缺点,如直接制作时其单体挥发出难闻的刺激性气味,易使患者感到恶心,