Attitude towards pre-implantation genetic diagnosis for hereditary cancer

The use of pre-implantation genetic diagnosis (PGD) for hereditary cancer is subject to on-going debate, particularly among professionals. This study evaluates the attitude towards PGD and attitude-associated characteristics of those concerned: family members with a hereditary cancer predisposition. Forty-eight Von Hippel-Lindau and 18 Li–Fraumeni Syndrome families were identified via the 9 family cancer clinics in the Netherlands. In total, 216 high risk family members and partners were approached, of whom 179 (83%) completed a self-report questionnaire. Of the high risk family members, 35% expressed a positive attitude towards PGD. Those with a current desire to have children were significantly more likely to have a positive attitude: 48% would consider the use of PGD. No other sociodemographic, medical or psychosocial variables were associated significantly with a positive attitude. The most frequently reported advantage of PGD is the avoidance of a possible pregnancy termination. Uncertainty about late effects was the most frequently reported disadvantage. These results indicate that approximately half of those contemplating a future pregnancy would consider the use of PGD. The actual uptake, however, is expected to be lower. There is no indication that psychosocial factors affect interest in PGD.     

Zur Casuistik des angeborenen und erworbenen Riesenwuchses

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Ueber Amblyopie und Amaurose bei Bright'scher Nierenkrankheit

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Beitrag zur Kenntnis der Flöhe von Brit.-Kolumbien

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Einige neue oder wenig bekannte Floharten

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Thallium-Vergiftung

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Zwei neue Rhopalopsyllusarten nebst einigen Bemerkungen über diese Gattung

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Anterolateral approach in bone grafting for ununited fractures of tibia

We have just presented a discussion of the technic used in carrying out an inlay sliding tibial bone graft through an anterolateral approach. The advantages of this approach over the old anterior approach have been discussed in detail. This discussion included the location of the incision and the reasons for its being so placed, the method of fixation with its advantages, and the utilization of morticing and impacting of the graft to further aid in fixation.We have summarized five cases in which this procedure was used, various methods of fixation being employed. The accompanying pictures show the progress of these cases.