盆底超声参数与SUI患者肌纤维疲劳度和病情程度的相关性分析

目的 探讨盆底超声参数与压力性尿失禁(SUI)患者病情程度、肌纤维疲劳度的相关性.方法 选取2018年10月至2020年3月该院SUI患者146例为研究对象,均接受盆底超声检查并给予盆底肌训练.分析盆底超声参数[膀胱颈旋转角度(θ)、膀胱颈下移距离(X)、膀胱颈移动度(Mu)、膀胱尿道后角(α)]与SUI问卷评分(SS)、肌纤维疲劳度的相关性,以及分析其预测SUI疗效不佳的价值.结果 不同病情程度患者年龄、受教育程度、年收入、分娩方式、会阴情况、流产次数和X比较差异无统计学意义(P>0.05),BMI、既往分娩次数、新生儿体重、θ、Mu、α比较差异有统计学意义(P<0.05).SUI患者X与SS、盆底肌纤维疲劳度无显著相关性(P>0.05),θ、Mu、α与SS评分、盆底肌纤维疲劳度呈正相关(P<0.05).疗效良好者θ、Mu、α低于疗效不佳者(P<0.05);θ预测的曲线下面积(AUC)最大,临界值37.35°时,其灵敏度、特异度分别为94.74％、59.84％.结论 盆底超声参数中θ、Mu、α与SUI患者肌纤维疲劳度、病情程度存在良好线性关系.     

肠减压后腹腔镜辅助右半结肠切除术在右半结肠癌伴肠梗阻中的应用

目的 探讨肠减压后腹腔镜手术与传统开腹手术在右半结肠癌并急性肠梗阻中的可行性与疗效.方法 回顾性分析2019年1月至2020年6月在该院普通外科就诊的53例急性右侧梗阻性结肠癌患者的病历资料.入选患者术前腹部立位平片及腹部CT均明确提示为右半结肠癌伴肠梗阻,不减压均无法建立腹腔镜操作空间,术后病理证实为结肠癌.根据其手术方式分为肠减压后联合入路翻页式腹腔镜辅助右半结肠癌根治术组(腹腔镜组,n=22)和传统开腹手术组(传统开腹组,n=31).比较两组患者的一般资料、手术时间、出血量、切口长度、肛门排气时间、术后住院时间及术后并发症的差异.结果 两组患者基线资料比较差异无统计学意义(P＞0.05).腹腔镜组、传统开腹组患者术中出血量分别为(24.48±7.57)、(69.00±12.87)mL,切口长度分别为(6.80±0.56)、(18.55±1.32)cm,肛门排气时间分别为(40.85±3.60)、(68.43±3.04)h,术后住院时间分别为(6.41±1.74)、(11.71±1.40)d,两组患者上述指标比较差异均有统计学意义(P＜0.05).腹腔镜组、传统开腹组患者手术时间分别为(171.47±9.01)、(185.18±9.40)min,两组患者手术时间及术后并发症(手术切口感染率、吻合口瘘、腹腔内出血、腹腔感染)比较,差异均无统计学意义(P＞0.05).结论 对右半结肠癌并急性肠梗阻患者采用肠减压后联合入路翻页式腹腔镜辅助右半结肠癌根治术具有创伤小、安全、有效等优势.     

Acupuncture Anesthesia for Radiofrequency Catheter Ablation in Treatment of Persistent Atrial Fibrillation: A Case Report

Atrial fibrillation(AF)is a clinically common arrhythmia,which is prone to cerebral infarction and heart failure.Radiofrequency catheter ablation(RFCA)is currently considered the standard first-line treatment.During RFCA,cells are dehydrated and necrotized through heat,thereby achieving pulmonary electrical isolation;patients may experience pain and discomfort in the process.     

Cupping Therapy for Diseases: An Overview of Scientific Evidence from 2009 to 2019

Cupping therapy has been accepted worldwide, and many studies have been conducted to reveal its curative effects and mechanisms. To comprehensively evaluate the effect of cupping therapy, database including China Network Knowledge Infrastructure (CNKI), Chinese Scientific Journal Database VIP, Wan Fang Database, Chinese Biomedicine (CBM), PubMed and Web of Science were searched from 2009–2019. We summarized all the meta-analyses, randomized controlled trials, clinical trials and the mechanisms studies of cupping therapy in the previous 10 years, hoping to provide a reference for the clinical applications and studies.     

Standard Operating Procedures for Chinese Medicine Data Monitoring Committees of Clinical Studies

Although there is guidance from different regulatory agencies, there are opportunities to bring greater consistency and stronger applicability to address the practical issues of establishing and operating a data monitoring committee (DMC) for clinical studies of Chinese medicine. We names it as a Chinese Medicine Data Monitoring Committee (CMDMC). A panel composed of clinical and statistical experts shared their experience and thoughts on the important aspects of CMDMCs. Subsequently, a community standard on CMDMCs (T/CACM 1323-2019) was issued by the China Association of Chinese Medicine on September 12, 2019. This paper summarizes the key content of this standard to help the sponsors of clinical studies establish and operate CMDMCs, which will further develop the scientific integrity and quality of clinical studies.     

四谈肝与咳喘哮——肝气虚所致咳喘哮证治述要

因肝肺关系密切,肝肺不和是诱发咳喘哮的重要病理机制。肝气虚致咳喘哮者临床并不少见,但两者之间的联系却甚少论及。本文试从肝气虚的识别要点、肝气虚诱发咳喘哮机制、表现及具体治法方药进行论述,以期进一步扩展、完善调肝理肺理论,指导临床。     

新型冠状病毒肺炎防控期间居家隔离人群心理健康状况调查及影响因素分析

目的 了解新型冠状病毒肺炎防控期间居家隔离人群心理健康状况并分析其影响因素,为进一步做好疫情防控工作,疏导不良情绪及心理恐慌提供依据.方法 选取2020年2月15 17日本研究团队7名研究生居住地为调查单位,采用自制一般情况调查表及12项一般健康问卷(GHQ-12)量表调查居家隔离的380人的心理健康状况.根据GHQ-12评分,将调查对象分为GHQ-12≥3分为阳性组(n=212)和GHQ-12＜3分为阴性组(n=168).采用Logistic回归模型分析居家隔离人群心理健康状况的影响因素.结果 两组在年龄、性别、是否独生子女、经济收入方面比较,差异无统计学意义(P＞0.05);而在居住地、婚姻状况、生育情况、担心感染、文化程度、职业方面差异有统计学意义(P＜0.05).多因素Logistic回归分析结果显示,居住地农村、初中及以下文化程度、已婚、学生、外出务工人员、担心感染是居家隔离人群心理健康的危险因素,年龄是其保护因素.结论 新型冠状病毒肺炎防控期间,居家隔离人群存在一定心理健康问题,其受多种因素影响.医院或社区卫生中心应针对不同人群进行心理疏导,改善其身心健康.     

Inverted U-Shaped Associations between Glycemic Indices and Serum Uric Acid Levels in the General Chinese Population: Findings from the China Cardiometabolic Disease and Cancer Cohort (4C) Study

Objective The relationship between serum uric acid(SUA)levels and glycemic indices,including plasma glucose(FPG),2-hour postload glucose(2 h-PG),and glycated hemoglobin(HbA1 c),remains inconclusive.We aimed to explore the associations between glycemic indices and SUA levels in the general Chinese population.Methods The current study was a cross-sectional analysis using the first follow-up survey data from The China Cardiometabolic Disease and Cancer Cohort Study.A total of 105,922 community-dwelling adults aged≥40 years underwent the oral glucose tolerance test and uric acid assessment.The nonlinear relationships between glycemic indices and SUA levels were explored using generalized additive models.Results A total of 30,941 men and 62,361 women were eligible for the current analysis.Generalized additive models verified the inverted U-shaped association between glycemic indices and SUA levels,but with different inflection points in men and women.The thresholds for FPG,2 h-PG,and HbA1 c for men and women were 6.5/8.0 mmol/L,11.0/14.0 mmol/L,and 6.1/6.5,respectively(SUA levels increased with increasing glycemic indices before the inflection points and then eventually decreased with further increases in the glycemic indices).Conclusion An inverted U-shaped association was observed between major glycemic indices and uric acid levels in both sexes,while the inflection points were reached earlier in men than in women.     

A Risk Prediction Model for Ischemic Stroke in Southern Chinese Population: Impact of Multiple Genetic Variants and Clinical/Lifestyle Factors

With a global prevalence of 7.7 million, ischemic stroke (IS) is one of the leading causes of death and disability worldwide. In China, IS alone contributed to 69.6％? of stroke events and accounted for 37.1％? of the mortality/disability rate[1]. IS is a complex disease that is known to be associated?with?various?genetic?variants?and?clinical and lifestyle risk factors[2]. Genome -wide association studies (GWAS) provided evidence for the?occurrence?of?more?than?160?IS-associated?single nucleotide?polymorphisms?(SNPs).?In?terms?of?clinical risk factors, patients with a history of chronic diseases like hypertension, dyslipidemia, and diabetes mellitus, display a higher risk of developing IS. Among the various lifestyle components, leading a sedentary lifestyle, smoking, and having an unhealthy diet are known to be associated with the risk of IS. Thus, integration of various genetic, clinical, and lifestyle variables might prove to be highly beneficial in the prediction and prevention of IS?at?the?individual?level[3].