射频微创治疗舌扁桃体肥大——附80例治疗效果及病因分析

目的探讨射频微创治疗舌扁桃体肥大的疗效,进一步分析舌扁桃体肥大的病因及综合治疗策略。方法纤维喉镜下诊断舌扁桃体肥大、舌根部淋巴滤泡增生80例。在间接喉镜下给予射频消融治疗。结果射频治疗后62例随访3个月~3年,未见复发;行二次射频治疗的2例,未见明显并发症;18例失访。结论舌扁桃体肥大的病因及综合治疗非常重要,射频治疗是治疗舌扁桃体肥大的有效方法。     

Outcomes of using Firebird rapamycin eluting stents in routine coronary intervention practice: one-year results from the pilot study of Firebird in China registry

Recent clinical trials with rapamycin-eluting stents have shown very low restenosis rates.1-4 However, the higher penetration of drug eluting stent (DES) in China is being limited by the high costs of these imported devices, especially when considering multiple stenting.     

Magnetic Iron Oxide Nanoparticles Mediated Gene Therapy for Cancer An In Vitro Study

The aim of this study was to evaluate the feasibility and efficacy of using TRAIL gene to treat breast cancer mediated with a novel carrier - magnetic iron oxide nanoparticles (polyMAG-1000) coated with PEI. The magnetic iron oxide nanoparticles were used as gene carrier to transfect TRAIL gene into MCF-7 cells. The polyMAG-1000 without TRAIL gene was transfected into the tumor cells as negative control. TRAIL gene transfection with liposome as carrier served as positive control. The apoptosis of cells was detected with TUNEL method. The apoptosis ratio of tumor cells was measured with flow cytometry (FCM). It was found that the apoptosis occurred in the tumor cells after transfection of TRAIL gene mediated by both polyMAG-1000 and liposome. The apoptosis ratio in the group with polyMAG-1000 as gene carrier was (25.11±2.85) %, whereas it was (5.06±1.05) % in the control group with polyMAG-1000 (P＜0.01). The apoptosis ratio was as low as (18.31±2.44) % in the group with liposome as gene carrier (P＜0.05, as compared with the group with polyMAG-1000 as gene carrier). It is suggested that TRAIL gene may induce apoptosis in MCF-7 breast cancer cells. The magnetic iron oxide nanoparticles coated with PEI may be a potential gene carrier with high transfection efficacy for cancer gene therapy.     

脉络膜裂蛛网膜囊肿的CT及MRI诊断

目的探讨脉络膜裂蛛网膜囊肿的CT、MRI表现.方法回顾分析经CT和MRI 诊断为脉络膜裂蛛网膜囊肿的患者18例,CT轴位扫描12例,冠状扫描3例,其中增强扫描8例.MR I进一步检查6例,直接MRI检查3例.结果18例病灶均发生于脉络膜裂区 ,右侧12例,左侧6例,均为单侧.直径为9～20mm,呈圆形或椭圆形,CT值5～20HU,增强扫描均无强化,与环池相连9例,灶周无水肿.结论CT和MRI均可检出脉络膜裂蛛网膜囊肿,但在定性诊断和鉴别诊断方面MRI明显优于CT.     

抗精神病药物对心电图的影响分析

目的：探讨抗精神病药物与心电图异常的关系．方法：对342例住院精神病人用药后ECG变化进行分析，以性别、年龄、住院时间进行比较．结果：174例ECG异常，各种药物所致ECG异常的发生率无明显差异。〉40岁者较〈40岁者ECG异常改变的明显增高．结论：抗精神病药物均可引起ECG异常。用药期间应注意定期检查ECG．     

上海市虹口区预防接种不良反应主动与被动监测情况分析

目的：为了解预防接种不良反应主动与被动监测情况，为AEFI监测体系提供科学依据。方法：采用对照比较的方法分析虹口区2005年1-9月主动与被动监测预防接种不良反应情况。结果：主动监测的发热、硬结、红肿反应发生率为731．53／10万、414．53／10万、170．69／10万显著高于被动监测73．78／10万、8．20／10万、16．40／10万，主动监测的过敏性皮疹反应率105．67／10万，显著高于被动监测6．56／10万。门诊自身前后比较，4-9月主动监测的发热、硬结、红肿反应发生率显著高于1-3月28．06／10万、56．12／10万、28．06／10万；1-3月被动监测异常反应为0,4-9月主动监测异常反应发生率为113．79／10万。结论：主动监测预防接种不良反应，敏感性高，特异性好，对于完善国家对异常反应的经济补偿政策：正确评估接种疫苗后可能发生的不良反应事件．并提出预防和处理建议．都具有重要意义。     

血清5''-核苷酸酶在消化道恶性肿瘤的诊断价值

目的探讨血清5’-核苷酸酶（5＇-NT）在消化道恶性肿瘤患者中的诊断价值。方法采用日立公司7170A全自动动生化分析仪测定60例健康人对照、42例肝癌患者、13例结肠癌患者及22例胃癌患者的5＇-NT水平。结果表明肝癌及鲒肠癌等患者5＇-NT显著高于健康人平均水平，P〈0.01及P〈0．05，而胃癌患者5＇-NT显著低于健康人的水平（P〈0．05）。结论测定血清5＇-NT的活性对消化道恶性肿瘤的诊治有重要意义。     

三尖杉属植物化学成分与药理活性研究进展

三尖杉属植物主要含有生物碱和黄酮两大类化学成分。因其三尖杉酯类生物碱具有抗癌活性,所以生物碱类成分得到了广泛的研究和重视。我国已将三尖杉酯碱HT和高三尖杉酯碱HHT开发成药物,对急性非淋巴细胞性白血病和慢性粒细胞性白血病有较好疗效。综述了三尖杉属植物的化学成分与药理活性研究进展,包括各类化合物的结构、药理活性、活性成分及衍生物的构效关系、HT和HHT的药理机制研究等。     

中药防治癌前病变现状及其机制

中药在防治食道癌前病变、口腔癌前病变、鼻咽癌前病变、胃癌前病变、肝癌前病变和宫颈癌前病变等方面取得了显著成效,其逆转癌前病变主要是通过调节细胞周期调控基因,细胞生长、增殖、分化调控基因及相关蛋白基因,细胞凋亡基因,转录因子等表达来发挥作用,另外中药还可对端粒酶活性、DNA水平等进行调整,也可能通过改善免疫相关基因如细胞黏附分子来提高机体的抗癌变能力。