全文获取类型
收费全文 | 238461篇 |
免费 | 19697篇 |
国内免费 | 8891篇 |
专业分类
耳鼻咽喉 | 2259篇 |
儿科学 | 5205篇 |
妇产科学 | 3052篇 |
基础医学 | 20860篇 |
口腔科学 | 4961篇 |
临床医学 | 25003篇 |
内科学 | 32615篇 |
皮肤病学 | 3519篇 |
神经病学 | 11606篇 |
特种医学 | 8763篇 |
外国民族医学 | 26篇 |
外科学 | 25836篇 |
综合类 | 42549篇 |
现状与发展 | 38篇 |
一般理论 | 47篇 |
预防医学 | 23556篇 |
眼科学 | 3139篇 |
药学 | 25644篇 |
187篇 | |
中国医学 | 14911篇 |
肿瘤学 | 13273篇 |
出版年
2024年 | 750篇 |
2023年 | 2135篇 |
2022年 | 5372篇 |
2021年 | 7195篇 |
2020年 | 6067篇 |
2019年 | 4277篇 |
2018年 | 4745篇 |
2017年 | 5407篇 |
2016年 | 4545篇 |
2015年 | 7297篇 |
2014年 | 9819篇 |
2013年 | 12633篇 |
2012年 | 17740篇 |
2011年 | 18716篇 |
2010年 | 16089篇 |
2009年 | 14459篇 |
2008年 | 16153篇 |
2007年 | 15972篇 |
2006年 | 14630篇 |
2005年 | 12195篇 |
2004年 | 10363篇 |
2003年 | 9078篇 |
2002年 | 8036篇 |
2001年 | 7123篇 |
2000年 | 6123篇 |
1999年 | 3817篇 |
1998年 | 1313篇 |
1997年 | 1072篇 |
1996年 | 992篇 |
1995年 | 900篇 |
1994年 | 812篇 |
1993年 | 769篇 |
1992年 | 1821篇 |
1991年 | 1795篇 |
1990年 | 1533篇 |
1989年 | 1472篇 |
1988年 | 1336篇 |
1987年 | 1212篇 |
1986年 | 1190篇 |
1985年 | 1053篇 |
1984年 | 776篇 |
1983年 | 716篇 |
1982年 | 465篇 |
1979年 | 567篇 |
1978年 | 415篇 |
1975年 | 429篇 |
1974年 | 479篇 |
1973年 | 461篇 |
1972年 | 422篇 |
1971年 | 392篇 |
排序方式: 共有10000条查询结果,搜索用时 8 毫秒
101.
儿童青光眼作为一种严重的潜在性致盲眼病,因儿童患者的特殊性,治疗困难,效果不佳.近年来,随着阀门植入手术的日益开展,有关青光眼阀门应用于儿童青光眼治疗的相关报道日渐增多.与其他手术方式相比,阀门植入手术对婴幼儿难治性青光眼显示出较好的疗效和安全性,表现在结膜下瘢痕较小,滤过泡壁纤维化少、渗透性更好,从而能够长期有效地控制眼压.它能够很好避免因瘢痕形成所致的滤过失败,并且滤过泡渗漏和感染等严重并发症的发生率也明显降低.但目前还缺乏有关于此的大样本、长期疗效和安全性研究. 相似文献
102.
A. I. Fabra De Peretti G. B. Mori De Moro N. E. Ghittoni A. M. Evangelista De Duffard R. O. Duffard 《Environmental toxicology》1987,2(2):217-228
The effects of 2,4-Dichlorophenoxyacetic acid on the growth rate, chemical composition, 14C-2,4-dichlorophenoxyacetic acid and 45Ca2+ uptake by Rhizobium sp. M 4 able to nodulate Arachis hypogaea were determined. Cellular growth was diminished by the presence of 10?3 M 2,4-dichlorophenoxyacetic acid in the medium. Alterations in cellular chemical composition, in 14C-2,4-dichlorophenoxyacetic acid and in 45Ca2+ uptake were found. 相似文献
103.
5-Fluorouracil, 5-fluorouridine (FUrd), 5-fluoro-2'-deoxyuridine (FdUrd), 5-fluorocytidine (FCyd), 5-fluoro-2'-deoxycytidine (FdCyd), 5-trifluoro-2'-deoxythymidine (F3dThd), and the 5'-monophosphates and 3',5'-cyclic monophosphates thereof were found to inhibit thymidine kinase-deficient (TK-) mutant strains of herpes simplex virus (HSV) at a much lower concentration than the wild-type (TK+) HSV strains. Other 5-substituted 2'-deoxyuridines that have previously been recognized as potent thymidylate synthase inhibitors behaved in a similar fashion. The activity of FdUrd, FdCyd, F3dThd, and their 3',5'-cyclic monophosphates against TK-HSV was readily reversed by 2'-deoxythymidine (dThd) but not by 2'-deoxyuridine (dUrd). These compounds also inhibited the incorporation of [6-3H]dUrd into DNA at a concentration which was up to 5 orders of magnitude lower than the concentration at which the incorporation of [methyl-3H] dThd was inhibited. Thus, while not being a target for the well established anti-HSV compounds in TK+HSV-infected cells, thymidylate synthase appears to be an important target in TK-HSV-infected cells. In addition to dTMP synthase, TK-HSV-infected cells appear to reveal other therapeutically exploitable targets such as OMP decarboxylase (towards pyrazofurin), CTP synthase (towards carbodine and its cyclopentenyl analogue), dihydrofolate reductase (towards methotrexate), and S-adenosylhomocysteine hydrolase (towards neplanocins). 相似文献
104.
2005年至2006年间,在皖南休宁县和屯溪区农村集中网报并纳入特殊疾病救治的有3个病人,其中确诊为人感染高致病性禽流感(H5N1)2例,救治成功1例。对前后3例的救治情况比较研究,认为人感染高致病性禽流感病人救治管理的核心环节有三:一是提高居民的择医意识,及时到专科诊治是救治成功的前提;二是提高基层医生专业知识水平,及时发现及时转医是核心环节;三是提高医院专科的救治能力,制订切实可行的应急预案,优化救治队伍,做出快速的反应,做到有效施治是救治成功的保证。 相似文献
105.
M A De Vroede M M Rechler S P Nissley H Ogawa S Joshi G T Burke P G Katsoyannis 《Diabetes》1986,35(3):355-361
Insulin and the insulin-like growth factors IGF-I and IGF-II are thought to exert their mitogenic effects in cultured chick embryo fibroblasts and human skin fibroblasts via IGF receptors rather than via insulin receptors. These effects appear to be mediated by the type I subtype of IGF receptor, which is structurally similar to the insulin receptor and exhibits significant cross-reactivity with insulin. As a first step in our long-range goal of defining those features of the IGF-I and IGF-II molecules that confer enhanced mitogenic activity and reactivity with these mitogenic type I IGF receptors, we have prepared two hybrid insulin-IGF molecules and examined their mitogenic and binding activities: (1) A27-insulin, containing an elongated 27-residue A-chain (in which the 6-residue D-domain of IGF-II was added to the carboxy-terminus of the 21-residue A-chain of insulin) combined with the B-chain of insulin; and (2) A insulin-B IGF-1, containing the A-chain of insulin and the synthetic 30-residue B-domain of IGF-I. Both hybrid molecules stimulated DNA synthesis and inhibited 125I-IGF-I binding to type I IGF receptors in both chick embryo and human fibroblast cultures. A27-insulin had considerably greater mitogenic potency and binding potency than A insulin-B IGF-I. Neither hybrid molecule was more potent in these assays than insulin, indicating that the presence of D IGF-II or B IGF-I by itself was not sufficient to increase the mitogenic potency of insulin in fibroblasts. By contrast, A insulin-B IGF-I showed enhanced reactivity with an antiserum to IGF-I. A27-insulin retained significant insulin-like metabolic activity despite the presence of the D-domain of IGF-II. 相似文献
106.
H. Verbraeken S. Ryckaert C. De Meunynck 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》1986,224(3):203-204
Eighty-two consecutive aphakic or pseudophakic retinal detachments were treated by buckling and vitrectomy procedures. Functional results (86.6%) and the incidence of proliferative vitreoretinopathy (11%) were comparable with reports of cases treated by the classic method.Presented at the 1984 meeting of the Club Jules Gonin in Lausanne, Switzerland 相似文献
107.
108.
2007年1月11日,中共中央政治局委员、国务院副总理吴仪在全国中医药工作会议上发表了重要讲话,该讲话从4个方面进行了论述,节选如下。 相似文献
109.
110.
Bruno Manzo Giuseppe Liistro Hugo De Clerck 《American journal of orthodontics and dentofacial orthopedics》2004,125(1):30-35
The purpose of this clinical trial was to evaluate the reliability and time saved with a plasma arc curing unit (Apollo 95E, Dental/Medical Diagnostic Systems, Woodland Hills, Calif) compared with a conventional curing unit (Ortholux XL 3000, 3M Unitek, St Paul, Minn) for direct bracket bonding with resin adhesive. Forty-five patients were involved in the study, and 608 brackets were bonded in a contralateral quadrant pattern. The patients were followed for a mean (+/- standard deviation) period of 11 +/- 3.2 months. Survival analysis was carried out to compare the failure rate for the 2 techniques. The time required for bonding with each technique was also recorded. The mean survival time was 399 days, and there were no significant differences in survival time between the 2 bonding methods. Twelve bonding failures were reported with each technique. The curing time per bracket was significantly reduced with the plasma curing light compared with a conventional curing unit (65 +/- 19 vs 82 +/- 31 seconds). The plasma arc curing light can save chair-time without affecting the bonding failure rate. 相似文献