穴位埋线治疗肝硬化患者胃动力障碍的疗效观察

目的：观察穴位埋线对肝硬化患者胃动力障碍的治疗作用。方法：将60 例患者随机分为埋线组和西药组,各30 例。埋线组采用穴位埋线治疗,选穴：肝俞、脾俞、中脘、足三里;西药组口服西沙比利片,4 周为一疗程,连续治疗1 个疗程后,观察两组患者治疗前后临床症状、肝功能及胃电参数情况。结果：两组治疗后临床症状、肝功能及胃电参数情况均明显改善（P<0.05）;与西药组比较,埋线组症状、肝功能及胃电参数各项指标明显改善（P<0.05）;埋线组总有效率90.0%,西药组总有效率60.0%,埋线组疗效优于西药组（P<0.05）。结论：穴位埋线是治疗肝硬化患者胃动力障碍的有效的方法。     

Identification of nine new HLA class I alleles in volunteers from the Singapore stem cell donor registries

Based on unusual probe hybridization patterns, two human leukocyte antigen (HLA)-A, five HLA-B, and two HLA-C alleles (A*240208, A*3211Q; B*1822, B*3938Q, B*4606, B*4607N, B*5139; Cw*0321, Cw*0734) were identified in individuals from the Singapore Bone Marrow Donor Program and Singapore Cord Blood Bank. Eight of the nine alleles encode amino acid substitutions altering the antigen-binding region including three alleles with changes altering a cysteine at codon 164 (A*3211Q, B*3938Q, B*4607N). This substitution either eliminates a key disulfide bond or results in a stop codon, both likely affecting the expression of the HLA molecules. Only one allele (A*240208) carries a synonymous substitution.     

轻微肝性脑病患者血清中代谢物组的研究

目的 检测轻微肝性脑病(minimal hepatic encephalopathy,MHE)患者血清中的代谢物组,初步建立MHE诊断模型.方法 采用核磁共振(NMR)方法检测25例肝硬化患者(肝硬化组)、25例轻微肝性脑病患者(MHE组)和30例健康对照(对照组)血清中的代谢物,应用主成分分析(PCA)和正交偏最小二...     

鼻咽癌组织中环氧化酶2和血管内皮生长因子C的相关性

目的探讨环氧化酶2(cyclooxygenase 2,COX-2)和血管内皮生长因子C(vascular endothelial growth factor C,VEGF-C)在鼻咽癌组织的表达及其相关性。方法应用免疫组织化学法检测45例鼻咽癌组织中COX-2和VEGF-C表达情况,并结合临床病理特征和随访资料进行分析。结果鼻咽癌组织中COX-2和VEGF-C表达的阳性率分别为68.9%(31/45)和53.3%(24/45),COX-2和VEGF-C之间表达有相关性(r=0.334,P<0.05),两者表达均与临床分期、颈淋巴结转移密切相关(P<0.05)。结论COX-2和VEGF-C在鼻咽癌组织中高表达并且呈正相关,两者在鼻咽癌的发生、发展及淋巴结转移中起重要作用,在鼻咽癌淋巴结转移中可能有协同效应。     

合曲林联合小剂量齐拉西酮治疗强迫症对照研究

目的探讨舍曲林联合小剂量齐拉西酮治疗强迫症的临床疗效和安全性。方法将76例强迫症患者随机分为研究组和对照组各38例,均口服舍曲林治疗,研究组联合小剂量齐拉西酮治疗,观察12周。于治疗前及治疗4周、8周、12周末采用Yale—Brown强迫量表评定l临床疗效,并随时记录不良反应发生状况。结果治疗后两组Yale—Brown强迫量表总分及各因子分均较治疗前显著下降（P〈0．05或0．01）,治疗8周、12周末研究组较对照组下降更显著（P〈0．01）;研究组起效时间显著早于对照组,治疗12周末总有效率显著高于对照组（P〈0．05）;两组不良反应均轻微,发生率比较差异无显著性（P〉0．05）。结论舍曲林联合小剂量齐拉西酮治疗强迫症疗效显著,起效快,不增加不良反应,显著优于单用舍曲林治疗。     

Reappraise role of lymph node status in patterns of recurrence following curative resection of gastric adenocarcinoma

ObjectiveTo examine the association between lymph node status and recurrence patterns in completely resected gastric adenocarcinoma.MethodsWe retrospectively assessed 1,694 patients who underwent curative gastrectomy from January 2010 to August 2014. Patients stratified according to lymph node status and recurrence patterns among different subgroups were compared.ResultsOf all, 517 (30.5%) patients developed recurrent disease, and complete data of recurrence could be obtained in 493 (95.4%) patients. For pN0 patients, the patterns of recurrence were different according to pT stage: locoregional recurrence was most common in patients with pT1−2 disease (57.1%), distant recurrence was most common in patients with pT3 disease (57.1%), and peritoneal recurrence was most common in patients with pT4a disease (66.7%). For pN+ patients, distant metastasis was most common pattern irrespective of pT stage. The site-specific trend of recurrence showed that locoregional recurrence increased within 5 years in patients with pN0−2 disease but plateaued 3 years after surgery in patients with pN3 disease. Time to recurrence was significantly longer for the pN0 patients compared with the pN+ patients (median: 25 vs. 16 months, P=0.001). Moreover, post-recurrence survival was significantly better for the pN0 patients than for the pN+ patients (median: 12 vs. 6 months, P<0.001), especially in patients with non-peritoneal recurrence, late recurrence, single recurrence, and receipt of potential curative treatment. ConclusionsAmong clinicopathologic factors, lymph node status is the most important factor associated with recurrence patterns after curative gastrectomy. Lymph node status may be used as an adjunct in clinical decision-making about postoperative therapeutic and follow-up strategies.     

HPLC法同时测定银黄制剂中的绿原酸和黄芩苷含量

目的:建立同时测定银黄制剂中绿原酸和黄芩苷的 HPLC 方法。方法:色谱柱为 Waters Symmetry C_(18)(3.9 mm×150mm,5μm)柱,以甲醇-0.4%磷酸水溶液为流动相,梯度洗脱(0→15 min,甲醇15%→55%;15→25 min,甲醇55%;25→28min,甲醇55%→15%)。流速为0.8 mL·min~(-1),检测波长为320 nm,0.02 AUFS。结果:绿原酸的线性范围为6.88～110.08μg·mL~(-1)(r=0.9996),平均回收率为97.4%,RSD 为2.2%(n:5);黄芩苷的线性范围为13.40～214.40μg·mL~(-1)(r=0.9998),平均回收率为96.7%,RSD 为2.0%(n=5)。结论:该方法简单、快速、准确,可为银黄制剂的质量控制提供实验依据。     

CVVH联合CRRT对脓毒血症伴急性肾功能衰竭患者肾功能损伤的修复作用

目的 观察持续静脉血液滤过(CVVH)联合连续性肾脏替代治疗(CRRT)对脓毒血症伴急性肾功能衰竭患者肾功能损伤的修复作用.方法 选取2018年7月—2019年7月福建医科大学附属协和医院急诊内科收治脓毒血症伴急性肾功能衰竭患者114例,按照随机数字表法分为CRRT组与联合治疗组,每组57例.CRRT组行CRRT,联合...     

武警反恐分队官兵个性特点和心理健康教育的相关性研究

目的探讨武警反恐分队官兵的心理健康状况与人格特征的关系。方法采用症状自评量表(SCL-90)和卡特尔16种人格测试量表随机抽取武警某部反恐分队官兵200名和普通官兵100名进行了调查分析。结果武警反恐分队官兵SCL-90测评中9项因子分均低于常模,与4种个性因素显著相关(P<0.05,P<0.01),与3种个性因素相关不显著(P>0.05),SCL-90的部分因子与其余9种个性因素相关显著(P<0.01)。结论武警反恐官兵的心理健康状况良好,受个性的影响较大。反恐分队官兵的人格特征可作为部队培养优秀人才的参照依据。     

Efficacy and safety of first-line chemotherapy plus bevacizumab in patients with metastatic colorectal cancer: a meta-analysis

Background What benefits and toxicities patients acquire from the use of bevacizumab combined with first-line chemotherapy remains controversial.This study was performed to evaluate the efficacy and safety of first-line chemotherapy plus bevacizumab in patients with metastatic colorectal cancer （mCRC）.Methods Several databases,including PubMed,Embase,and Cochrane Library,were searched up to April 30,2013.Eligible studies were only randomized,controlled trials （RCTs） with a direct comparison between mCRC patients treated with and without bevacizumab.Overall risk ratio （RR）,hazard ratio （HR）,odds ratio （OR）,and 95％ confidence intervals （CO were calculated employing fixed or random-effects models depending on the heterogeneity of the included trials.Results Six RCTs,including 1582 patients in chemotherapy plus bevacizumab group and 1484 patients in chemotherapyalone group,were included.Overall,the addition of bevacizumab to first-line chemotherapy increased overall response rate （ORR） by 4.5％,prolonged both progression-free survival （PFS） and overall survival （OS）,and increased the rate of total Grades 3 or 4 adverse events （G3/4AEs） by 6.9％.Significant differences were found in ORR （RR=1.22 （95％ CI 1.01-1.46）,P=0.03）,PFS （HR=0.60 （95％ Cl 0.47-0.77）,P ＜0.0001）,OS （HR=0.83 （95％ Cl 0.70-0.97）,P=0.02）,and any G3/4AEs （OR=1.56 （95％ Cl 1.29-1.89）,P ＜0.00001）.Conclusion Bevacizumab is a valuable addition to the current first-line chemotherapy regimens used in patients with mCRC,because of conferring a significant improvement in ORR,PFS,and OS,even though it increased adverse events.