全文获取类型
收费全文 | 27796篇 |
免费 | 2866篇 |
国内免费 | 2222篇 |
专业分类
耳鼻咽喉 | 286篇 |
儿科学 | 293篇 |
妇产科学 | 237篇 |
基础医学 | 2774篇 |
口腔科学 | 427篇 |
临床医学 | 3480篇 |
内科学 | 3579篇 |
皮肤病学 | 290篇 |
神经病学 | 1593篇 |
特种医学 | 1092篇 |
外国民族医学 | 7篇 |
外科学 | 2882篇 |
综合类 | 6046篇 |
现状与发展 | 8篇 |
一般理论 | 1篇 |
预防医学 | 2258篇 |
眼科学 | 601篇 |
药学 | 3193篇 |
20篇 | |
中国医学 | 1780篇 |
肿瘤学 | 2037篇 |
出版年
2024年 | 120篇 |
2023年 | 465篇 |
2022年 | 1236篇 |
2021年 | 1437篇 |
2020年 | 1113篇 |
2019年 | 939篇 |
2018年 | 947篇 |
2017年 | 916篇 |
2016年 | 803篇 |
2015年 | 1240篇 |
2014年 | 1669篇 |
2013年 | 1605篇 |
2012年 | 2216篇 |
2011年 | 2397篇 |
2010年 | 1827篇 |
2009年 | 1479篇 |
2008年 | 1629篇 |
2007年 | 1625篇 |
2006年 | 1564篇 |
2005年 | 1324篇 |
2004年 | 1026篇 |
2003年 | 1133篇 |
2002年 | 911篇 |
2001年 | 706篇 |
2000年 | 642篇 |
1999年 | 456篇 |
1998年 | 293篇 |
1997年 | 234篇 |
1996年 | 164篇 |
1995年 | 142篇 |
1994年 | 133篇 |
1993年 | 75篇 |
1992年 | 63篇 |
1991年 | 68篇 |
1990年 | 58篇 |
1989年 | 53篇 |
1988年 | 41篇 |
1987年 | 26篇 |
1986年 | 28篇 |
1985年 | 19篇 |
1984年 | 19篇 |
1983年 | 4篇 |
1981年 | 4篇 |
1965年 | 5篇 |
1963年 | 3篇 |
1962年 | 2篇 |
1958年 | 4篇 |
1957年 | 5篇 |
1955年 | 3篇 |
1935年 | 2篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
992.
目的 探讨磁共振多b值技术在鉴别肝脏局灶性病变中的应用价值,提高对肝脏局灶性病变的正确诊断率。方法 选取我院 2016年9月~2018 年10月行磁共振检查的肝脏占位病变75例患者为研究对象,其中恶性病变患者40例,良性病变患者35例。同时选取同期健康志愿者30名在GE MR750引导下行MR扫描,记录多b值扩散加权成像不同性质肝脏局灶性病变的信号强度、ADC值,观察不同性质病变的b值 信号强度和b值 ADC值曲线的差异、特点。 结果 肝脏局部良性病变者与肝脏局部恶性病变者的肝脏局灶性病变的信号强度、ADC值,不同性质病变的b值 信号强度和b值ADC值曲线均有显著性差异(P<0.05)。结论 通过MRI扫描序列的设立及多b值的测算,对扫描结果进行综合分析、判断,可鉴别肝脏不同性质局灶性病变的性质,提高正确诊断率,具有较好的诊断价值。 相似文献
993.
目的对比研究复合因素法与利血平皮下注射法所致脾气虚证模型大鼠的临床证候特征。方法将30只雄性SD大鼠随机分为正常组、复合因素组及利血平组,分别采用两种方式造模后,通过一般体征指标及证候量化评分评价临床证候表现;旷场实验评价大鼠心理及自主活动;检测血清D-木糖含量判断消化吸收能力。结果与正常组相比,两模型组大鼠证候量化评分总积分及各单项均升高(P<0.05,P<0.001),且利血平组各个单项及总积分均高于复合因素组(P<0.05);两组大鼠自主活动均较正常组减少(P<0.05);与复合因素组相比,利血平组穿格次数、中央区停留时间、活动距离下降尤为明显(P<0.001);与正常组相比,两组大鼠血清D-木糖含量均下降(P<0.01),两模型组之间差异无统计学意义(P>0.05)。结论两种造模方式都可造成大鼠脾气虚证候,但其临床证候表现有所不同,实验时应结合需求进行选择。 相似文献
994.
995.
目的:分析直肠癌术后腹腔内感染与肌肉减少症之间的关系,并构建联合模型预测腹腔内感染风险。方法:收集383例接受结直肠癌根治术的患者,在手术前收集并测量诊断肌肉减少症的三要素,包括腰椎骨骼肌指数、术前握力和步行速度。通过单因素和多因素分析确定影响腹腔内感染的因素。构建由独立风险因素组成的联合预测模型,以量化结直肠癌术后腹腔内感染的个体风险。结果:383例患者中,有93例被诊断出肌肉减少症,而44例被诊断出腹腔内感染。Logistic分析表明,肌肉减少症、肿瘤大小、年龄是
结直肠癌术后腹腔内感染的独立预后因素(P <0.05)。腹腔内感染的联合预测模型能够可靠地预测及量化结直肠癌术后发生腹腔内感染的风险(一致性指数为0.710)。结论:术前肌肉减少症是结直肠癌术后发生腹腔内感染的的独立预测因子。本联合预测模型是一种简单实用的工具,可量化腹腔内感染的个体风险,用于识别高风险患者。 相似文献
996.
Hai Xiang Jianqiang Gao Baoquan Yu Hui Zhou Dawei Cai Youwen Zhang Xiaoyong Chen Xi Wang Michael Hofreiter Xingbo Zhao 《Proceedings of the National Academy of Sciences of the United States of America》2014,111(49):17564-17569
Chickens represent by far the most important poultry species, yet the number, locations, and timings of their domestication have remained controversial for more than a century. Here we report ancient mitochondrial DNA sequences from the earliest archaeological chicken bones from China, dating back to ∼10,000 B.P. The results clearly show that all investigated bones, including the oldest from the Nanzhuangtou site, are derived from the genus Gallus, rather than any other related genus, such as Phasianus. Our analyses also suggest that northern China represents one region of the earliest chicken domestication, possibly dating as early as 10,000 y B.P. Similar to the evidence from pig domestication, our results suggest that these early domesticated chickens contributed to the gene pool of modern chicken populations. Moreover, our results support the idea that multiple members of the genus Gallus, specifically Gallus gallus and Gallus sonneratii contributed to the gene pool of the modern domestic chicken. Our results provide further support for the growing evidence of an early mixed agricultural complex in northern China.In his epochal work on domestication, Darwin suggested that domestic chicken (Gallus gallus domesticus) originated from red jungle fowl (Gallus gallus gallus) ∼4,000 y B.P. in the Indus Valley (1). However, more recent evidence, based on both mitochondrial (mt) and nuclear DNA (2–4), refutes a monophyletic origin of G. g. domesticus. Analyses of large-scale mtDNA datasets (5) strongly suggest that chickens were domesticated multiple times in different parts of Asia, including regions in South Asia, Southwest China, and Southeast Asia. Although some of the earliest chicken bones have been discovered in northern China, dating to over 10,000 B.P. at the Nanzhuangtou site and to over 7,000 B.P. at several other sites (e.g., Cishan and Peiligang), northern China has not yet been suggested as a center of chicken domestication for two main reasons. First, it is unclear if the discovered bones really represent domesticated rather than wild members of the genus Gallus (6), and second, northern China is currently a semiarid steppe, and therefore does not provide suitable habitat for jungle fowl, the wild ancestor of domestic chicken. However, abundant remains of tropical animal and plant species excavated at the Cishan and Nanzhuangtou sites show that northern China was much warmer and more humid, with much more extensive forest coverage during the early Holocene (7, 8), providing a potentially suitable habitat for jungle fowl at this time. Moreover, previous studies have revealed northern China as a center for both early pig domestication (9) and the earliest millet domestication (10, 11) already by 10,000 B.P., showing that agriculture existed in this region at the time to which the earliest chicken bones date.Previous studies (9, 12, 13) have shown that ancient DNA analyses can be informative with regard to determining the places of domestication for a species. The time, region, and pattern of chicken domestication in particular regions over the world have also been worked out using ancient DNA analysis (14–17). However, the oldest chicken sequences analyzed to date are only around 4,000 y old, substantially postdating the beginning of chicken domestication.Therefore, we chose 39 ancient chicken bones from three archaeological sites in the area of the Yellow River (Cishan, Nanzhuangtou, and Wangyin), representing the earliest sites for chicken bones both in northern China and worldwide, and one younger archaeological site in the middle area of the Yangtze River (Jiuliandun Chu Tombs) for ancient DNA analyses (Fig. 1 and Table S1.Open in a separate windowFig. 1.Examples of ancient chicken bones and localities of all investigated samples. (A) Map of China showing the location of the four archaeological sites (red dots). (B) Typical ancient chicken bones unearthed in northern China. (C) Close-up of the Yellow River area from which the samples originate. The sites are marked with yellow dots with white asterisks.
Open in a separate window 相似文献
Table 1.
Summary of ancient samples analyzedLocation | Sample size | Age (archaeological context, B.P.) | Source |
Nanzhuangtou site, Hebei, China | 22 | 10,465–10,430 direct/10,500–9,700 associated | Present study |
Cishan site, Hebei, China | 7 | 7,960–7,845 direct/7,500–7,300 associated | |
Wangyin site, Shandong, China | 6 | 4,500–3,500 associated dates | |
Jiuliandun Chu tombs, Hubei, China | 4 | 3,000–2,300 associated dates | |
Albarracin, Spain | 1 | 1,450–1,000 | Storey et al. (15) |
Valduno, Spain | 1 | After 1,000 | |
La Cartuja, Spain | 1 | 350–280 | |
Luala''i, Waimea, Hawai''i | 1 | After 1,000 | |
Pelekane site, Hawai''i | 1 | After 1,000 | |
Puu Lanai Ranch site, Hawai''i | 2 | After 1,000 | |
El Arenal 1, Chile | 2 | Cal. 622 ± 35 B.P. and Cal. 506 ± 30 B.P., respectively | Storey et al. (14, 15, 18) |
Hanga Hahave, Easter Island | 1 | Prehistoric and context of classic, Ahu-Moai Period Crematoria |
997.
998.
Jillian R. Hufgard Jenna L.N. Sprowles Emily M. Pitzer Sheryl E. Koch Min Jiang Qin Wang Xiang Zhang Jacek Biesiada Jack Rubinstein Alvaro Puga Michael T. Williams Charles V. Vorhees 《Journal of applied toxicology : JAT》2019,39(4):603-621
Polychlorinated biphenyls (PCBs) are toxic environmental pollutants. Humans are exposed to PCB mixtures via contaminated food or water. PCB exposure causes adverse effects in adults and after exposure in utero. PCB toxicity depends on the congener mixture and CYP1A2 gene activity. For coplanar PCBs, toxicity depends on ligand affinity for the aryl hydrocarbon receptor (AHR). Previously, we found that perinatal exposure of mice to a three‐coplanar/five‐noncoplanar PCB mixture induced deficits in novel object recognition and trial failures in the Morris water maze in Cyp1a2?/?::Ahrb1 C57BL6/J mice compared with wild‐type mice (Ahrb1 = high AHR affinity). Here we exposed gravid Cyp1a2?/?::Ahrb1 mice to a PCB mixture on embryonic day 10.5 by gavage and examined the F1 and F3 offspring (not F2). PCB‐exposed F1 mice exhibited increased open‐field central time, reduced acoustic startle, greater conditioned contextual freezing and reduced CA1 hippocampal long‐term potentiation with no change in spatial learning or memory. F1 mice also had inhibited growth, decreased heart rate and cardiac output, and impaired fertility. F3 mice showed few effects. Gene expression changes were primarily in F1 PCB males compared with wild‐type males. There were minimal RNA and DNA methylation changes in the hippocampus from F1 to F3 with no clear relevance to the functional effects. F0 PCB exposure during a period of rapid DNA de‐/remethylation in a susceptible genotype produced clear F1 effects with little evidence of transgenerational effects in the F3 generation. While PCBs show clear developmental neurotoxicity, their effects do not persist across generations for effects assessed herein. 相似文献
999.
目的:设计组织尼美舒利含量测定的能力验证项目(编号NIFDC-PT093),评价药品检测机构电位滴定法的测定能力。方法:对参加实验室的测定结果进行稳健统计分析,用Z比分数评价实验室检测能力。结果:共153家实验室反馈了结果,其中33个参加实验室(占21.6%)的结果可疑或不满意。省级以上食品药品检验机构的满意率(占92.6%)高于其他机构。结论:本次能力验证项目检测结果主要受滴定液、电极、电位滴定仪、空白试验和溶剂的影响,建议离群者可采取调整滴定液浓度、选择合适电极和滴定参数等措施以保证结果的准确。 相似文献
1000.
目的探讨血小板源性生长因子D(PDGF-D)与髓过氧化物酶(MPO)在大肠癌组织和大肠腺瘤组织中的表达及其临床意义。方法通过免疫组织化学染色法检测大肠癌组织及大肠腺瘤组织中PDGF-D与MPO的表达及其相关性。采用免疫组化染色方法检测88例大肠癌石蜡包埋组织、72例大肠腺瘤组织中PDGF-D与MPO的表达,并分析MPO和PDGF-D的表达与大肠癌临床病理特征的关系。结果大肠癌组织中PDGF-D与MPO阳性表达率分别为85.23%、63.64%,均显著高于大肠腺瘤组织(34.72%、27.78%),差异有统计学意义(P0.01)。PDGF-D与MPO在大肠癌组织中的表达呈正相关(r=0.29,P0.05)。结论 PDGF-D与MPO可能参与了大肠癌的启动及发生过程,在大肠癌的发生、发展和转移过程中起着重要作用。 相似文献