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161.
目的:探讨黄芪注射液对SHR心肌SERCA的表达及血管平滑肌钙离子含量的影响.方法:将19只自发性高血压大鼠(SHR)与16只Wistar-kyoto大鼠(WKY)随机各分为空白对照组、低黄芪剂量组、中黄芪剂量组、高黄芪剂量组四组,分别每天腹腔注射0.9ml生理盐水和0.9ml、1.2ml、1.8ml的黄芪注射液共8周,再测量大鼠心肌中SERCA的表达和血管平滑肌钙离子含量.结果:SHR生理盐水组心肌SERCA在蛋白水平的表达,较WKY生理盐水组明是下降;SHR大剂量黄芪组心肌SERCA在蛋白水平的表达,较SHR生理盐水组明显升高.SHR生理盐水组血管平滑肌钙离子水平明显高于WKY组:SHR大剂量黄芪组血管平滑肌钙离子水平较SHR生理盐水组明显降低.结论:大剂量黄芪注射液能显著增加SHR心肌SERCA在蛋白水平的表达,能明显的减少SHR血管平滑肌钙离子的水平. 相似文献
162.
Involvement of Apoptosis in 3-nitropropionic Acid-induced Ischemicl Tolerance to Transient Focal Cerebral Ischemia in Rats 总被引:3,自引:0,他引:3
Preconditioningofbraintissueswithsub lethalstressesorstimulicanresultinresistancetosubse quentlethalischemiceventsinaresponsecalledis chemictolerance .Recently ,severalstudieshaveshownthatasinglesystemicdoseof 2 0mg/kg 3 NPAcausednohistopathologicalabnorm… 相似文献
163.
Objective To study the protective effects of adenovirus-mediated human beta-nerve growth factor gene (hNGFβ) transfer combined with iron fortified nutrition on blast hearing damage in guinea pigs. Methods Deafness was induced by blast (172dB SPL) in 35 healthy guinea pigs. Seven days after noise exposure, 10 guinea pigs were inoculated with adenovirus-mediated hNGFβ (Ad-hNGFβ) into the perilymphatic space (the gene group), another 10 guinea pigs were given hNGFβ combined with iron fortified nutritional diet (the combination group), still another 10 guinea pigs were inoculated with artificial perilymphatic fluid (APF), and 5 guinea pigs served as control, given neither medicine nor noise exposure. Auditory brainstem response (ABR) threshold shifts were monitored in the guinea pigs before blast exposure and after gene transfer. Changes in cochlear morphology were examined with immunohistochemical and HE staining. Results One week after successful inoculation of hNGFβ, it was noted that Ad-hNGFβ protein was expressed in each turn of the cochlea, and its intensity was almost equal. After gene transfer in the combination group and the gene group, ABR threshold shifts at week 1 and 4 were significantly smaller than those of the APF group. HE staining showed that the number of the spiral ganglion cells in the combination group and the Ad-hNGFβ group was significantly higher than that of the control group after 4 weeks (P<0.01). Conclusions Ad-hNGFβ combined with iron fortified nutritional diet was effective in the prevention and treatment of blast hearing damage of cochlear hair cells. 相似文献
164.
165.
贲门失驰缓症介入治疗的疗效评价 总被引:1,自引:0,他引:1
目的:评价贲门失弛缓症球囊扩张介入治疗的疗效。方法:对20例贲门失驰缓症患者行球囊扩张术。结果:20例患者共进行了31次球囊扩张,人均1.5次(其中12例扩张1次,5例扩张2次,3例扩张3次)。术后患者吞咽困难明显缓解,主要并发症为疼痛和返流。术后随访无症状期为3-13个月。结论:球囊扩张术是治疗门失弛缓症的有效方法。 相似文献
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169.
Effect of Ligustrazine on Bone Marrow Microenvironment and Signal Transducti on Path in Irradiation Injured Mice
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Lan Sun Wen-li Liu Han-ying Sun Tian-hua Ren Deng-ju Li Hui-zhen Xu Wu Lu 《中国结合医学杂志》2002,8(4):295-298
Wehavereported previouslythatligustrazinecouldpromotehematopoiesisthroughimprovingbonemarrowmicroenvironmentandenhancingadhesive 相似文献
170.
The promoting effect of the Chinese medicinal herb, Wikstroemia chamaedaphne and Tung oil extracts (WC and HHPA) on carcinoma of uterine cervix induced by HSV-2 or MCA in mice was studied. The results showed that WC and HHPA extracts were not carcinogenic themselves. After carcinogen HSV-2 and MCA treatment, WC and HHPA were added separately. The inducing rates by HSV-2 increased from 7.4% to 21.1% and 26.3%, those by MCA increased from 56.5% to 82.8% and 84.4%. There was a significant difference between the combined groups and groups with HSV-2 or MCA only. The experimental results suggest that these two kinds of extracts play a promoting effect on carcinogenesis. The relation between the carcinogenesis of uterine cervix or nasopharynx and WC or HHPA extracts is discussed. 相似文献