血管移植搭桥治疗巨大动脉瘤

目的探讨中、高流量血管搭桥方法对颅内巨大颅内动脉瘤的治疗。方法8例巨大和颅底复杂动脉瘤患者,主要表现头痛发病者5例,视力减退者2例,面部麻木者1例。未破裂动脉瘤6例,2例患者发生动脉瘤破裂,Hunt-Hess分级分别为Ⅰ级和Ⅱ级。血管造影证实：动脉瘤体位于颈内动脉海绵窦段（C4段）4例、床突上段（C1段）2例、大脑中动脉M2～M1段者2例动脉瘤大小为2．5～6．0cm,平均直径3．7cm。其中6例动脉瘤为梭形,2例为宽颈动脉瘤。8例患者均采用额颞开颅,骨瓣要尽可能低到颅底,以缩短搭桥移植血管在颅外走行长度。通常用7-0显微缝线吻合移植血管与颈外动脉,用8-0缝线吻合移植血管与颅内段颈内动脉和大脑中动脉。4例患者利用大隐静脉移植搭桥,4例患者利用桡动脉移植搭桥。颅内、外搭桥完毕后将动脉瘤近心端和远端的供血动脉结扎和夹闭,阻断动脉瘤的全部血供。对3例有压迫脑神经或颅内占位引起颅压高的患者,将动脉瘤切除。结果5例术后头痛消失,1例视力减退者明显改善,1例动眼神经麻痹恢复。5例术后行脑血管造影检查,3例行CT血管造影检查,7例搭桥吻合血管全部畅通,动脉瘤消失。2例术后出现暂时性一侧肢体力弱,肌力在Ⅱ～Ⅲ级之间,术后1个月完全恢复。结论中、高流量颅内外血管搭桥可作为治疗颅内巨大动脉瘤的有效方法。     

Clinicopathological features of bladder cancer associated with chronic exposure to arsenic.

A high incidence of bladder cancer has been documented in an area of chronic arsenic (As) exposure. This study investigates the characteristics of As-associated (n = 49) and other (n = 64) bladder cancers. A higher histological grading was observed for the As-exposed tumours (P = 0.04), but no other difference in pathobiological features or prognosis was found between the two groups.     

膀胱移行细胞癌中P16及Rb基因表达的关系

应用免疫组织化学方法对５９例膀胱移行细胞癌中Ｐ１６及Ｒｂ基因的表达进行研究。结果显示：５９例中Ｐ１６及Ｒｂ基因阳性表达率分别为４７４６％、７１１９％，其中１１例肿瘤组织（１８６４％）Ｐ１６及Ｒｂ基因均阳性表达，未发现同一肿瘤组织中同时存在Ｐ１６及Ｒｂ基因的表达缺失。Ｐ１６及Ｒｂ基因在膀胱移行细胞癌中的阳性表达率在肿瘤病理分级及临床分期的差异中均有显著性（Ｐ＜００５）。结果提示：Ｐ１６及Ｒｂ基因的异常表达在膀胱肿瘤的发生、发展过程中起重要作用，膀胱肿瘤中Ｐ１６及Ｒｂ基因同时表达缺失是少见现象     

Unsteady diffusion kinetics of Ziegler-Natta heterogeneous catalyst polymerization, 4. Prediction of experimental results of propylene/ethylene/1-hexadecene terpolymerization

The prediction, based on unsteady diffusion kinetics, of the enhancement of reactivity and incorporation of 1-hexadecene in its copolymerization with propylene on adding a small amount of ethylene (increase from 5,2 mol-% to 10,8 mol-% when 2% of ethylene was added, and to 16, 1 mol-% when 5% was added) was verified in the terpolymerization of propylene/ 1-hexadecene/ ethylene on a commercial Solvay-type δ-TiCl₃ catalyst. The catalyst efficiency was thus also increased. These augmentations originate from the increase in diffusion coefficient of 1-hexadecene at the catalyst surface when the PP crystallinity decreases on introduction of ethylene. Calculation based on unsteady diffusion kinetics showed that the order of diffusion coefficients ethylene > propylene > 1-hexadecene is reversed as the monomer concentration increases when the monomers are not at their equilibrium concentration. Sequence distribution as determined by means of ¹³C NMR revealed a tendency of blocky structure rather than a Bernoullian one. The terpolymer compositions obtained by means of an IR method developed in this work conform rather well with the NMR results. Results in this work not only support the unsteady diffusion kinetics but also provide a new route to prepare olefinic copolymer rubbers with heterogeneous titanium catalysts.     

复方栀子冲剂栀子甙薄层扫描测定

应用薄层扫描法测定了复方栀子冲剂中栀子甙的含量，对实验条件，以正交试验法进行优选，确定了最佳方案，排除了干扰，得到了满意的效果。     

The electrophysiological effects of dicentrine on the conduction system of rabbit heart.

1. The electrophysiological effects of dicentrine, an aporphine alkaloid isolated from the root of Lindera megaphylla, were examined in the Langendorff perfused rabbit heart and rabbit isolated cardiac cells. 2. Standard electrophysiological characters were measured in the Langendorff perfused rabbit heart (control study) and after 5 min exposure to 1, 3 and 9 microM of dicentrine and during the subsequent recovery phase sequentially (n = 7). The same study protocols were performed in 0.5 to 4.5 microM quinidine (n = 7), 18 to 162 microM procainamide and N-acetylprocainamide (n = 7) for comparison. 3. The results showed that the spontaneously beating heart rate and the sinoatrial (SA) and atrioventricular nodal (AH) conduction time were not significantly affected by dicentrine but were significantly suppressed by the higher doses of quinidine (4.5 microM) and procainamide (162 microM). 4. The His-Purkinje conduction time was significantly increased by the higher dose of dicentrine, quinidine and procainamide. 5. The ventricular repolarization time and its effective refractory period were significantly increased by the higher dose of dicentrine and the other agents. 6. The effective refractory period of the atrium, AV node and His-Purkinje system were also significantly increased by dicentrine and the other agents. 7. A voltage clamp study revealed that the prolongation of atrial action potential duration by dicentrine (9 microM) was associated with a significant inhibition of the transient potassium outward current. As well as inhibition of the transient outward current, a significant inhibition of the sodium inward current by dicentrine was found.(ABSTRACT TRUNCATED AT 250 WORDS)     

生物粘附制剂的进展

生物粘附制剂是应用于组织粘膜的一类新型制剂。本文综述了生物粘附机理、常用的生物粘附材料以及生物粘附制剂的进展。     

Influence of Qingdai Compound Capsule on the expression of c-myc in psoriatic keratinocytes) on the expression of c-myc in psoriatic keratinocytes

In this immunohistochemical study, the authors detected the expression of c-myc in keratinocytes (ECK) from 30 psoriatics before and after Qingdai Compound Capsule (QDCC) treatment and 12 normal subjects for control. The results showed that the ECK of patients before treatment was significantly higher than that in the normal control group, and its level was correlated with histopathological changes of affected skin. After treatment the ECK was normalized. It is believed that QDCC could decrease the ECK in psoriatics and this effect was probably mediated by inhibiting c-myc expression. This study provided an experimental evidence for the application of QDCC in treating psoriasis.     

医技人员血源性疾病感染情况调查

医务人员的医院内感染逐渐被人们所关注，其中血源性疾病的感染更应引起大家的重视。为了了解医务人员中医师、检验人员的医院感染发生情况，笔者对某中心医院的医师和检验人员的2002年度体检结果进行了统计分析，现报告如下。     

99mTc标记结肠癌单克隆抗体片段CEA．Fab的研制方法

目的　探讨一种高效便捷的99mTc CEA Fab标记化合物的研制方法。方法　采用 2 亚氨噻酚盐酸盐修饰CEA Fab ,通过GH转换 ,将99mTc标记在结肠癌单克隆抗体CEA Fab上。结果　已修饰抗体的标记率为 93.5 %,99mTc胶体含量为 2 .5 %,标记化合物有良好的稳定性和免疫活性。结论　成功地建立了结肠癌单抗片断CEA Fab的99mTc标记方法 ,该技术可以应用于其他抗体片段标记领域。