心肌血流储备分数在选择冠脉介入治疗中的应用

目的 评价心肌血流储备(myocardial fractional flowreserve，FFRmyo)分数在选择冠脉介入治疗中的作用。方法 选择冠脉狭窄在50％～70％之间、FFRmyo≥0．75的患者12例，随机分成进行和不进行冠脉介入治疗两组，治疗后每3个月进行活动平板试验，对心脏状况进行评价，共12个月。结果 对于FFRmyo值≥0．75的患者，无论是否进行冠脉介入治疗，心脏事件发生率、临床症状改善程度均无明显差别。结论 FFRmyo是冠脉狭窄功能评价的理想指标，对指导临床治疗以及治疗的正确选择具有重要价值。     

Extralobar pulmonary sequestration with venous drainage to the portal vein: a case report

Venous drainage to the portal vein in pulmonary sequestration is rare. A 7-month-old girl was referred to our hospital following surgery for ventricular septal defect because of a left upper abdominal mass with a large feeding artery from the abdominal aorta and venous drainage to the portal vein. She had had frequent pulmonary infections and was growth retarded. MRI demonstrated that the mass was above the left diaphragm, suggesting extralobar sequestration. An extralobar sequestered lung was resected at thoracotomy. Diagnostic problems and clinical features are presented. Received: 29 April 1999/Accepted: 10 December 1999     

Implication of two additional lateral peripheral zone biopsy in the detection of prostate cancer

BACKGROUND: Despite the strenuous efforts in improving detection of prostate cancer, no standard technique for prostatic biopsy has been established to date. Extended tissue sampling in peripheral zone may possibly lead to enhanced prostate cancer detection. METHODS: Four hundred thirty-three candidates for ultrasound-guided prostatic biopsy were alternately assigned to two groups regarding biopsy techniques between January 1997 and June 1998, Group A, sextant biopsy group and Group B, two additional lateral peripheral zone sampling after standard sextant biopsy. The outcomes of prostatic biopsy were compared. RESULTS: Cancer detection rates were 19.2% (43/217) in Group A and 18.5% (40/216) in Group B. No statistically significant difference was noted (p > 0.05). Clinical stage, Gleason score and the presence of metastasis did not differ significantly between groups (p > 0.05). The incidence and duration of hematuria, hematospermia were essentially the same between groups (p > 0.05). High fever due to possible bacteremia developed only in Group B patients (p = 0.04). CONCLUSIONS: Routine use of additional peripheral zone biopsy is not recommended owing to the equivalent cancer detection rates between groups. The application of additional biopsy should be determined carefully since this may lead to increased incidence of serious complications.     

Phase II trial of docetaxel (Taxotere(R)) in metastatic colorectal carcinoma

BACKGROUND:: Docetaxel (Taxotere^®) is prepared from a non-cytotoxic precursorextracted from the needles of the Taxus baccata. Preclinicalinvestigations have demonstrated that docetaxel is very activein colon adenocarcinoma murine models. Phase I studies revealedgranulocytopenia to be the dose-limiting toxicity. Initial clinicaltrials also demonstrated docetaxel's activity in ovarian, breast,and non-small cell lung cancer. Because of this encouragingpreclinical and clinical activity, we initiated a phase II studyof docetaxel in patients with metastatic colorectal carcinoma. PATIENTS AND METHODS:: Docetaxel, 100 mg/m², was administered as a 1-hour intravenousinfusion every 21 days. Nineteen patients were entered on thetrial. All patients had measurable disease and had not receivedprior chemotherapy for metastatic disease. RESULTS:: No complete or partial responses were observed. Granulocytopeniawas the dose-limiting toxic effect. Seventeen patients had grade4 granulocytopenia; 8 of these patients received antibioticsfor neutropenic fevers. Twelve patients experienced hypersensitivityreactions, and 15 patients experienced cutaneous toxic reactions.One patient demonstrated evidence of fluid retention. CONCLUSIONS:: Administered at the stated dose and schedule, docetaxel haslittle activity against metastatic colorectal carcinomas. Thetoxicity profile, consisting of granulocytopenia, hypersensitivityreactions, cutaneous reactions, and edema, has been previouslydescribed in patients receiving docetaxel. docetaxel, Taxotere^®, paclitaxel, Taxol^®, colorectal carcinomas, colon carcinoma, rectal carcinoma     

Effect of operator variability on void formation in impressions made with an automixed addition silicone

This study examined voids produced in impressions of an automixed addition-reaction silicone. Two operators took the impressions using material dispensed from either intra-oral tips or an impression syringe. The material was also hand-mixed for comparison. There were no differences in the number of voids in the automixed material dispensed using the intra-oral tip or impression syringe. Automixing produced substantially fewer voids than hand-mixing. There was a significant difference in the number of voids in the impressions made by the two operators.     

Malocclusion severity in Asian men in relation to malocclusion type and orthodontic treatment need.

INTRODUCTION: The purpose of this study was to assess the severity of malocclusion in young Asian men in relation to types of malocclusion and orthodontic treatment need. METHODS: Study models of 339 male army recruits (age, 17-22 years) with no history of orthodontic treatment were assessed. The peer assessment rating (PAR) index was used to determine the severity of their malocclusions. Logistic regression and receiver operating characteristics (ROC) curves were performed to evaluate the PAR index in relation to treatment need assessed by the dental health component (DHC) and the esthetic component (EC) of the index of orthodontic treatment need. RESULTS: The mean PAR scores were 17, 20, 28, and 18 for Class I, Class II Division 1, Class II Division 2, and Class III, respectively. PAR scores were highly correlated with DHC and EC scores (P < .001). An increase of 1 point in the PAR score significantly increased the likelihood of orthodontic treatment need for dental-health reasons or esthetic impairment (by 1.17 times [95% CI 1.13-1.21] or 1.25 times [95% CI 1.19-1.31]). The areas under the ROC curves for PAR index were 84% and 94% for the DHC and EC assessments, respectively, suggesting that PAR scores were better predicators of esthetic than dental health impairment for assessing Asian malocclusions. The optimum cutoff points were PAR scores of 17 and 20 for dental health and esthetic impairment, respectively. CONCLUSIONS: Class II malocclusions were more severe than Class I or III in Asian men. Malocclusions with definite treatment need had PAR scores that were significantly greater than those with borderline, little, or no need. ROC curves showed that the PAR index had an acceptable level of validity with the professional assessment of orthodontic treatment need in Asian malocclusions. The optimum cutoff PAR scores were 17 and 20 in relation to DHC and EC assessment, respectively. The PAR index was more predictive of esthetic than dental health need.