Character and frequency of pathological changes in the solitary rat kidney after removal of the other kidney in old age

One kidney was removed from male rats weighing 500–850 g; the remaining kidney underwent compensatory hypertrophy and, after 1–2 months, it was larger (index of hypertrophy 70–92%) in rats weighing 700–850 g than in animals weighing 500–600 g (56–58%). Histological investigation showed that this marked hypertrophy of the solitary kidney in old rats was not the result of disease of the organ, for pathological changes such as are sometimes found in intact and hypertrophied kidneys were found in only 38 of 223 animals. The results suggest that the ability of the kidneys to undergo, compensation and regeneration is not reduced in old age.Laboratory of Growth and Development, Institute of Human Morphology, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR A. P. Avtsyn.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 84, No. 9, pp. 362–366, September, 1977.     

邻近皮瓣修复颌面部软组织缺损34例的临床应用

目的评价应用邻近皮瓣修复颌面部软组织缺损的临床效果。方法对34例颌面部软组织缺损创面术后分别采用推进皮瓣、旋转皮瓣等多种方法转移修复。结果34例患者术后创面均I期修复,术后外形满意。结论邻近皮瓣设计灵活,采用适当的方法修复颌面部软组织缺损可以取得良好效果。     

自体骨髓基质细胞回输促进急性白血病病人化疗后骨髓造血恢复的研究

目的通过回输成纤维集落生成单位（CFU—F）促进骨髓实质细胞造血恢复。减轻白血病化疗的副作用，促进骨髓损伤早日恢复。方法选取经明确诊断的AML患者化疗回输组前后行自身对照，化疗回输前及后采骨髓行红系造血祖细胞（BFU-E）、粒、巨系集落生成单位（CFU—GM）培养，观察化疗回输前后的外周血象。结果化疗回输CFU-F后第3周。其BFU—E、CFU-GM数明显高于化疗回输前的水平（P〈0．05）。同时高于单纯化疗组第3周测得的BFU-E和CFU-GM数（P〈0．05）。结论体外扩增造血基质细胞于化疗自体回输方法，促进了病人造血恢复，对预防和减轻化疗药物造成的骨髓损伤，缩短化疗间期，加大化疗药物剂量，具有理论意义和应用价值。     

Effect of chalone-containing aorta extracts on regression in experimental atherosclerosis

The effect of chalone-containing aortic extracts on proliferative activity of smooth muscle cells was examined in conditions of experimental hypercholesterolemia. The tissue-specific cell proliferation inhibitor present in the extract is shown to depress mitotic activity of smooth muscle cells in postnatal rats. The area under aortic atherosclerotic lesion diminished twofold as compared to that of the controls. Morphologically, atherosclerotic changes are seen as lipid plaques.     

MYELIN PROTEIN P-0-SPECIFIC IGM PRODUCING MONOCLONAL B CELL LINES WERE ESTABLISHED FROM POLYNEUROPATHY PATIENTS WITH MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE (MGUS)

We attempted to develop a mouse model for peripheral neuropathy by a partial injury of the nerve supplying the tail. Under enflurane anesthesia, the unilateral superior caudal trunk was resected between the S3 and S4 spinal nerves. Tests for thermal allodynia were conducted by immersing the tail into 4 or 38°C water. The mechanical allodynia was assessed by stimulating the tail with a von Frey hair (1.96 mN, 0.2 g). After the nerve injury, the experimental animals had shorter tail withdrawal latencies to cold and warm water immersion than the presurgical latency, and exhibited an increase in tail response to von Frey stimulation. We interpret these abnormal sensitivities as the signs of mechanical, cold and warm allodynia following the superior caudal trunk injury in the mouse.     

良好保存血管在体形态取材的一种方法

０　引言　我们观察了动脉血管的固定方法（浸泡固定或灌注固定）、固定时血管的生理状态（处于收缩或舒张）等因素对保存血管在体形态的影响．１　材料和方法１．１　材料　雄性ＳＤ大鼠（体质量２５０ｇ～３００ｇ）９只．动物被随机分为３组（每组３只），分别用于浸泡固定法（Ｉ组）、生理压力下４０ｍＬ／Ｌ多聚甲醛灌注固定（Ｓ组）、低压下Ｋｒｅｂｓ液预灌注４０ｍＬ／Ｌ多聚甲醛灌注固定（Ｄ组）对血管在体形态的影响的观察．动物饲养与实验均遵照第四军医大学实验动物饲养与使用规定进行．１．２　方法　３组动物均采用腹腔内注射…