全文获取类型
收费全文 | 4099篇 |
免费 | 519篇 |
国内免费 | 17篇 |
专业分类
耳鼻咽喉 | 23篇 |
儿科学 | 111篇 |
妇产科学 | 200篇 |
基础医学 | 366篇 |
口腔科学 | 42篇 |
临床医学 | 1222篇 |
内科学 | 636篇 |
皮肤病学 | 50篇 |
神经病学 | 180篇 |
特种医学 | 173篇 |
外科学 | 544篇 |
综合类 | 148篇 |
一般理论 | 4篇 |
预防医学 | 286篇 |
眼科学 | 48篇 |
药学 | 352篇 |
中国医学 | 31篇 |
肿瘤学 | 219篇 |
出版年
2024年 | 11篇 |
2023年 | 73篇 |
2022年 | 47篇 |
2021年 | 148篇 |
2020年 | 79篇 |
2019年 | 100篇 |
2018年 | 177篇 |
2017年 | 176篇 |
2016年 | 163篇 |
2015年 | 169篇 |
2014年 | 210篇 |
2013年 | 253篇 |
2012年 | 244篇 |
2011年 | 248篇 |
2010年 | 192篇 |
2009年 | 181篇 |
2008年 | 192篇 |
2007年 | 188篇 |
2006年 | 170篇 |
2005年 | 131篇 |
2004年 | 135篇 |
2003年 | 111篇 |
2002年 | 108篇 |
2001年 | 81篇 |
2000年 | 72篇 |
1999年 | 73篇 |
1998年 | 48篇 |
1997年 | 74篇 |
1996年 | 68篇 |
1995年 | 57篇 |
1994年 | 44篇 |
1993年 | 41篇 |
1992年 | 53篇 |
1991年 | 39篇 |
1990年 | 54篇 |
1989年 | 48篇 |
1988年 | 33篇 |
1987年 | 37篇 |
1986年 | 35篇 |
1985年 | 25篇 |
1984年 | 33篇 |
1983年 | 24篇 |
1982年 | 25篇 |
1981年 | 21篇 |
1979年 | 19篇 |
1978年 | 22篇 |
1977年 | 15篇 |
1976年 | 12篇 |
1975年 | 13篇 |
1972年 | 11篇 |
排序方式: 共有4635条查询结果,搜索用时 15 毫秒
31.
32.
Remodeling Adult Nursing 总被引:1,自引:0,他引:1
This article describes a nursing education experience in which a critical thinking approach was planned and implemented. Background discussion on critical thinking concepts and related research provides a foundation for presentation of the Mackie teaching model. The model uses a community-based, family-centered scenario as the basis for developing problemfocused nursing intervention skills from a holistic viewpoint. Role expectations of students and faculty are outlined, and related implementation difficulties, together with their resolution strategies, are described. Evaluation methods and outcomes are reviewed in the conclusion. 相似文献
33.
To learn and teach about HIV/AIDS is to enter complex and senstitive territory that at times may be personally challenging. 5 In the vast literature on HIV infection and nursing two main themes recur: nurses' lack of understanding, negative attitudes and anxieties related to HIV/AIDS and the need for education to change such attitudes and enhance nurses' knowledge and skills. 相似文献
34.
We have previously reported the purification of a 37 kDa platelet agglutinating protein (PAP p37) from the plasma of a patient with thrombotic thrombocytopenic purpura (TTP) that was shown to be present in a subset of TTP patients. To gain further insight into the interaction between PAP p37 and platelets, we have studied the properties of PAP p37 binding to platelets. Washed human platelets from two normal donors and two TTP patients after recovery were used for the experiments. The PAP p37 binding to platelets was specific, concentration dependent and saturable. Scatchard analysis demonstrated about 20,564-27,090 PAP p37 binding sites per platelet. Stimulation of platelets with thrombin or ADP did not have any significant effect on its binding. Thiol- and serine-specific protease inhibitors did not inhibit PAP p37 binding to the platelets. Sugars such as glucose, fructose, mannose, and sialic acid, at 40 mM, inhibited its binding to platelets by 44%, 73%, 79%, and 91% respectively, but galactose and amino sugars did not have any significant effect. At 250 micrograms/ml, Concanavalin-A inhibited 42% of binding, but other lectins, such as phytohemagglutinin-P, potato lectin and helix pomatia lectin (snail), did not. Pre-incubation of 125I-PAP p37 with the adult human IgG, decreased its binding to the platelets. The monoclonal antibodies to GP Ib (6D1) and GP IIb-IIIa complex (10E5) did not inhibit the binding of 125I-PAP p37 to platelets. Fibrinogen and von Willebrand factor did not affect the binding either. These results suggest that PAP p37 binds to platelets on the sites other than GP Ib or GP IIb-IIIa complex. 相似文献
35.
36.
Patti Besuner RN MN CNS Steven Imhoff RN MSN CNP 《Newborn and Infant Nursing Reviews》2007,7(4):211-215
Complete and accurate knowledge is critical to parent decision making for families with complex and/or life-threatening fetal conditions. Comprehensive fetal centers are available to provide multidisciplinary specialized assessment, evaluation, diagnosis, and nondirectional counseling. Interventional option may include fetoscopic procedures, open fetal surgery, and ex utero intrapartum treatment. The nurse coordinator serves as the family and health care provider liaison for arrangement of services and communication of the plan of care. 相似文献
37.
topic . How impaired personal boundaries play a significant role in mental illnesses and co-dependency.
purpose . To demonstrate the value of having a formal nursing diagnosis of "impaired personal boundaries."
source . A concept analysis of personal boundaries, which describes the physical, emotional, intellectual, and spiritual dimensions of personal boundaries.
conclusion . The author recommends a new nursing diagnosis of "impaired personal boundaries," which provides a basis for the plan of care for clients with this difficulty. 相似文献
purpose . To demonstrate the value of having a formal nursing diagnosis of "impaired personal boundaries."
source . A concept analysis of personal boundaries, which describes the physical, emotional, intellectual, and spiritual dimensions of personal boundaries.
conclusion . The author recommends a new nursing diagnosis of "impaired personal boundaries," which provides a basis for the plan of care for clients with this difficulty. 相似文献
38.
Wang S Saboorian MH Frenkel EP Haley BB Siddiqui MT Gokaslan S Wians FH Hynan L Ashfaq R 《American journal of clinical pathology》2001,116(4):495-503
This retrospective study of formalin-fixed infiltrating breast cancer specimens compared manual immunohistochemical assay with a new image analyzer-assisted immunohistochemical quantitation method, using fluorescence in situ hybridization assay (FISH) as the standard. Following the manual immunohistochemical assay, 189 cases, including most manual immunohistochemically positive and some random negative cases, were analyzed by FISH assay for Her-2/neu gene amplification and by the Automated Cellular Imaging System (ACIS) for immunohistochemical staining. Using the FISH standard, the ACIS immunohistochemical assay attained a higher concordance rate and sensitivity than the manual immunohistochemical assay (91.0% and 88% vs 85.7% and 71%, respectively), with only a slight decrease in specificity (93% vs 96%, respectively). In particular, the ACIS immunohistochemical assay resulted in a higher correlation with the FISH assay in the manual immunohistochemical assay 2+ cases. The ACIS immunohistochemical assay achieved higher accuracy than the manual method according to receiver operating characteristic curve analysis. The ACIS method represents a substantial improvement over the manual method for objective evaluation of the HER-2/neu status. 相似文献
39.
Induction of protective immunity to monoclonal-antibody-defined Plasmodium falciparum antigens requires strong adjuvant in Aotus monkeys. 总被引:3,自引:4,他引:3
W A Siddiqui L Q Tam S C Kan K J Kramer S E Case K L Palmer K M Yamaga G S Hui 《Infection and immunity》1986,52(1):314-318
Monoclonal antibodies to the major Plasmodium falciparum merozoite surface coat and rhoptry antigens were produced. A combination of the affinity-purified polypeptides with Freund complete adjuvant which was given three times completely protected an Aotus lemurinus azure (karotype VI) monkey against homologous challenge; however, immunization with the same polypeptides with a muramyl dipeptide derivative [MDP-Lys(L18)] did not protect a second Aotus monkey, even though comparable high antibody titers were induced. 相似文献
40.
Suppression of lymphocyte transformation by plasma from owl monkeys acutely infected with Plasmodium falciparum. 下载免费PDF全文
Plasma collected from owl monkeys during the acute phase of Plasmodium falciparum infection was shown to adversely affect several in vitro responses which are considered to be correlates of cell-mediated immune functions of normal monkeys. In the presence of acute-phase plasma, response of normal monkey peripheral blood lymphocytes to stimulation with phytohemagglutinin, concanavalin A, and pokeweed mitogen was severely reduced, as was the ability of peripheral blood lymphocytes to respond to allogenic and xenogenic histocompatible antigens. The transformation response of peripheral blood lymphocytes from normal humans to phytohemagglutinin and concanavalin A was also suppressed. Since acute-phase plasma was not cytotoxic for peripheral blood lymphocytes, decreased responsiveness did not result from cell destruction. Acute-phase plasma appears to block initial steps in lymphocyte transformation. 相似文献