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991.
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Riggs PD Winhusen T Davies RD Leimberger JD Mikulich-Gilbertson S Klein C Macdonald M Lohman M Bailey GL Haynes L Jaffee WB Haminton N Hodgkins C Whitmore E Trello-Rishel K Tamm L Acosta MC Royer-Malvestuto C Subramaniam G Fishman M Holmes BW Kaye ME Vargo MA Woody GE Nunes EV Liu D 《Journal of the American Academy of Child and Adolescent Psychiatry》2011,50(9):903-914
994.
Sinnema M Boer H Collin P Maaskant MA van Roozendaal KE Schrander-Stumpel CT Curfs LM 《Research in developmental disabilities》2011,32(5):1729-1735
Previous studies have suggested an association between PWS and comorbid psychiatric illness. Data on prevalence rates of psychopathology is still scarce. This paper describes a large-scale, systematic study investigating the prevalence of psychiatric illness in a Dutch adult PWS cohort. One hundred and two individuals were screened for psychiatric illness. Case vignettes were written by the first author on 63 individuals with a positive screening on psychopathology according to the interviews, medical history, medication use and behavioural questionnaires. These case vignettes were rated by two psychiatrists specializing in intellectual disability (ID). Psychopathology was divided into four diagnostic categories: bipolar disorder with psychotic symptoms, psychotic illness, depressive illness with psychotic symptoms and depressive illness without psychotic symptoms. Nine out of 53 persons (17%) with a 15q11-13 deletion and 28 out of 44 (64%) persons with maternal uniparental disomy (mUPD) were diagnosed with a current or previous psychiatric illness. Depressive illness with psychotic symptoms was the cause of psychiatric problems in the majority of persons with PWS due to deletion (56%). In the case of mUPD, almost all individuals with histories of psychopathology suffered from psychotic symptoms (85%) with or without affective component. Psychiatric examination should be part of general management of adults with PWS, especially when caused by mUPD. More attention should be paid to the presence of precursor symptoms, indicating a developing psychiatric episode. Longitudinal studies are needed to gain more insight into the natural history of psychiatric illness in adults with PWS. 相似文献
995.
Rahbar H Partridge SC Eby PR Demartini WB Gutierrez RL Peacock S Lehman CD 《European radiology》2011,21(9):2011-2019
Objectives
To characterize ductal carcinoma in situ (DCIS) and its subtypes on diffusion-weighted imaging (DWI). 相似文献996.
Demartini WB Kurland BF Gutierrez RL Blackmore CC Peacock S Lehman CD 《European radiology》2011,21(8):1609-1617
Objectives
To predict the probability of malignancy for MRI-detected breast lesions with a multivariate model incorporating patient and lesion characteristics.Methods
Retrospective review of 2565 breast MR examinations from 1/03?C11/06. BI-RADS 3, 4 and 5 lesions initially detected on MRI for new cancer or high-risk screening were included and outcomes determined by imaging, biopsy or tumor registry linkage. Variables were indication for MRI, age, lesion size, BI-RADS lesion type and kinetics. Associations with malignancy were assessed using generalized estimating equations and lesion probabilities of malignancy were calculated.Results
855 lesions (155 malignant, 700 benign) were included. Strongest associations with malignancy were for kinetics (washout versus persistent; OR 4.2, 95% CI 2.5?C7.1) and clinical indication (new cancer versus high-risk screening; OR 3.0, 95% CI 1.7?C5.1). Also significant were age >?=?50?years, size >?=?10?mm and lesion-type mass. The most predictive model (AUC 0.70) incorporated indication, size and kinetics. The highest probability of malignancy (41.1%) was for lesions on MRI for new cancer, >?=?10?mm with washout. The lowest (1.2%) was for lesions on high-risk screening, <10?mm with persistent kinetics.Conclusions
A multivariate model shows promise as a decision support tool in predicting malignancy for MRI-detected breast lesions. 相似文献997.
Alyson McIntosh M.D. Neal Dunlap M.D. Ke Sheng Ph.D. Constance Geezey C.M.D. Benton Turner C.M.D. Leslie Blackhall M.D. Geoffrey Weiss M.D. Eric Lappinen M.D. James M. Larner M.D. Paul W. Read M.D. Ph.D. 《Medical Dosimetry》2011,35(4):280-286
Helical tomotherapy–based STAT radiation therapy (RT) uses an efficient software algorithm for rapid intensity-modulated treatment planning, enabling conformal radiation treatment plans to be generated on megavoltage computed tomography (MVCT) scans for CT simulation, treatment planning, and treatment delivery in one session. We compared helical tomotherapy–based STAT RT dosimetry with standard linac-based 3D conformal plans and standard helical tomotherapy–based intensity-modulated radiation therapy (IMRT) dosimetry for palliative treatments of whole brain, a central obstructive lung mass, multilevel spine disease, and a hip metastasis. Specifically, we compared the conformality, homogeneity, and dose with regional organs at risk (OARs) for each plan as an initial step in the clinical implementation of a STAT RT rapid radiation palliation program. Hypothetical planning target volumes (PTVs) were contoured on an anthropomorphic phantom in the lung, spine, brain, and hip. Treatment plans were created using three planning techniques: 3D conformal on Pinnacle3, helical tomotherapy, and helical tomotherapy–based STAT RT. Plan homogeneity, conformality, and dose to OARs were analyzed and compared. STAT RT and tomotherapy improved conformality indices for spine and lung plans (CI spine = 1.21, 1.17; CI lung = 1.20, 1.07, respectively) in comparison with standard palliative anteroposterior/posteroanterior (AP/PA) treatment plans (CI spine = 7.01, CI lung = 7.30), with better sparing of heart, esophagus, and spinal cord. For palliative whole-brain radiotherapy, STAT RT and tomotherapy reduced maximum and mean doses to the orbits and lens (maximum/mean lens dose: STAT RT = 2.94/2.65 Gy, tomotherapy = 3.13/2.80 Gy, Lateral opposed fields = 7.02/3.65 Gy), with an increased dose to the scalp (mean scalp dose: STAT RT = 16.19 Gy, tomotherapy = 15.61 Gy, lateral opposed fields = 14.01 Gy). For bony metastatic hip lesions, conformality with both tomotherapy techniques (CI = 1.01 each) is superior to AP/PA treatments (CI = 1.21), as expected. Helical tomotherapy–based STAT RT treatment planning provides clinically acceptable dosimetry, with conformality and homogeneity that is superior to standard linac-based 3D conformal planning and is only slightly inferior to standard helical tomotherapy IMRT dosimetry. STAT RT facilitates rapid treatment planning and delivery for palliative radiation of patients with metastatic disease, with relative sparing of adjacent OARs compared with standard 3D conformal plans. 相似文献
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999.
Cauquil-Michon C Flamand-Roze C Denier C 《Current neurology and neuroscience reports》2011,11(6):570-577
Borderzone infarcts (BZIs) are anatomically defined as ischemic lesions occurring at the junction between two arterial territories,
accounting for 2% to 10% of strokes. Three types of hemispheric BZIs are described according to topography (ie, superficial
anterior, posterior, and deep). Although published series on related aphasia are rare in the setting of BZI, aphasia is of
transcortical (TCA) type, characterized by the preservation of repetition. TCA can be of motor, sensory, or mixed type depending
on whether expression, understanding, or both are impaired. Recent studies have reported specific aphasic patterns. BZI patients
initially presented with mixed TCA. Aphasia specifically evolved according to the stroke location, toward motor or sensory
TCA in patients with respectively anterior or posterior BZI. TCA was associated with good long-term prognosis. This specific
aphasic pattern is interesting in clinical practice because it prompts the suspicion of a BZI before the MRI is done, and
it helps in the planning of rehabilitation and in providing adapted information to the patient and family concerning the likelihood
of language recovery. 相似文献
1000.