学报创刊15周年暨增刊通报

学报创刊１５周年暨增刊通报正值《中山医科大学学报》创刊１５周年之际，本刊编辑部于１９９５年６月１７日召开了“学报创刊１５周年总结会”。本刊编辑部主任、副主编关淡庄同志作了总结报告。首先感谢了学报的各位前辈为学报的创刊和发展所立下的汗马功劳，再次感谢了...     

慢性粒细胞白血病100例骨髓组织病理学Hannover分类法意义探讨

本文对100例慢性粒细胞白血病(CML)患者进行组织病理学研究,应用Hannover国际分类法进行分类,观察到骨髓组织病理学中巨核细胞增多者临床症状较重,中位生存时间较短,认为该分类法对临床及预后判断有指导意义,比既往应用的Bartl及Frisch分类法优越。     

AN EEG STUDY OF 120 EPILEPTIC FAMILIES

To study the epilepsy heredity, routine EEG tracings of 120 epileptic families and 57 normal control families were carried out. The results suggest that epilepsy shows an obvious tendency to be inherited.     

乌鲁木齐市维汉族学龄儿童细胞免疫功能及影响因素的探讨

本文应用植物血凝素(PHA)检测了乌市维汉族学龄儿童的细胞免疫功能。结果表明,汉族儿童的PHA红斑直径均值高于维族,不论维汉族男女生均以9～10岁年龄段PHA红斑均值最大,并有随年龄增加而下降的趋势。同时对缺铁性贫血、生长发育水平及营养状况对细胞免疫功能的影响进行了初步探讨。     

先天性心脏病导管介入治疗对小儿生长发育和内分泌功能的影响

目的　了解先天性心脏病 (CHD)导管介入治疗对患儿生长发育和内分泌功能的影响。方法　测定 4 2例CHD患儿导管介入治疗前后的身高、体重和三碘甲状腺原氨酸 (T3)、甲状腺素 (T4 )、促甲状腺素 (TSH)、生长激素(HGH)。结果　治疗前后身高、体重的增长速度明显改善 ,而T3、T4、TSH、HGH无明显改变。结论　导管介入治疗能明显改善先心病患儿生长发育而不会影响患儿的内分泌功能     

局部手法按摩用于扩张皮瓣的初步探讨

目的总结局部手法按摩用于扩张皮瓣的初步经验。方法自2006年至2007年，我们将手法按摩用于扩张器置入预扩张皮瓣患者21例（35个扩张器）。采用预定的按摩手法，对置入扩张器的皮瓣进行适当按摩。结果本组21例患者，1例因感染取出扩张器，余20例效果满意。与以往未经手法按摩扩张器置入术比较，注水速度明显增快，扩张周期明显缩短。结论局部手法按摩用于扩张皮瓣，安全可靠，效果明显，值得推广。     

高危新生儿脑干听觉诱发电位的近期观察

目的 为了解高危新生儿脑干及听觉功能障碍情况.方法 于1995年8月～1996年1月对128例高危新生儿进行脑干听觉诱发电位(Anditory Brainstem Responses—ABR)测定.结果 急性期高危新生儿ABR异常率为51.4%,其中高胆红素血症,低体重儿,窒息和丁胺卡那霉素应用组ABR异常率分别为61.1%、66.7%、53.8%和 2.8%.血清胆红素(Sb)值>290.7μmol/L和重度窒息儿ABR异常率明显高于Sb<290.7μmol/L和轻度窒息儿.早产儿和足月小样儿ABR异常率无明显差异.丁卡组对听阀的近期影响不大.结论 高危新生儿是脑干和听觉功能障碍的高危人群,应当密切随防和早期干预.     

手部热压伤的早期修复(附43例报告)

目的 探讨早期清创、组织修复在热压伤治疗中的临床疗效。方法 分析43例不同程度手部热压伤患的病损特点并行临床分度，以便准确诊治、判断预后；全部病例采用早期手术治疗，轻度热压伤(即浅Ⅲ度烧伤)早期行切痂全厚或中厚皮片修复，中度和重度热压伤早期彻底清创保留间生态组织，应用血循环丰富的组织瓣修复创面。结果 42例创面一期修复，手功能和外形恢复满意：1例创面二期修复，手功能恢复差。结论 手部热压伤应早期手术清创，据病损程度选择良好的方法及时修复组织缺损，可最大限度地恢复手功能和外形，减少致残率，缩短疗程，获得较好的临床疗效。     

Term delivery in a woman with severe congenital neutropenia, treated with growth colony stimulating factor

The patient was diagnosed in childhood as having severe congenital neutropenia and had recurrent admissions with severe infections. In 1987, prior to getting married, she was sterilized. She continued to require i.v. antibiotics when she contracted a severe infection. On one occasion, she was treated with growth colony stimulating factor (G- CSF). Her increased neutrophil count was sustained following this treatment. In June 1993, she wished to start a family and underwent in- vitro fertilization (IVF) treatment. G-CSF was given prior to oocyte retrieval. She conceived on her first cycle and an ultrasound scan revealed a singleton pregnancy. Throughout the course of the pregnancy, her white cell count was monitored closely and remained at <1.0x10(9)/l. The pregnancy progressed uneventfully and at 37 weeks gestation she was admitted for G-CSF injections. At 38 weeks she was delivered of a boy weighing 3350 g, by elective Caesarean section. His white cell count was normal. This is the first case of G-CSF being used before conception and during pregnancy in a patient with congenital neutropenia. It shows that advances in cytokine therapy and close interdisciplinary liaison can lead to a successful outcome and help patients, who would otherwise remain childless, to achieve a family.      

Distribution of spermatogenesis in the testicles of azoospermic men: the presence or absence of spermatids in the testes of men with germinal failure [published erratum appears in Hum Reprod 1998 Mar;13(3):780]

The aim of the study was to determine whether a prior diagnostic testicle biopsy can predict success or failure of testicular sperm extraction (TESE) with intracytoplasmic sperm injection (ICSI) in patients with non-obstructive azoospermia caused by testicular failure, and what is the minimum threshold of sperm production in the testis which must be surpassed for spermatozoa to reach the ejaculate. Forty- five patients with non-obstructive azoospermia caused by testicular failure underwent diagnostic testicle biopsy prior to a planned future TESE-ICSI procedure. The diagnostic testicle biopsy was analysed quantitatively, and correlated with the quantitative findings of spermatogenesis in patients with normal spermatogenesis, as well as with the results of subsequent attempts at TESE-ICSI. Men with non- obstructive azoospermia caused by germinal failure had a mean of 0-6 mature spermatids/seminiferous tubule seen on a diagnostic testicle biopsy, compared to 17-35 mature spermatids/tubule in men with normal spermatogenesis and obstructive azoospermia. These findings were the same for all types of testicular failure whether Sertoli cell only, maturation arrest, cryptorchidism, or post-chemotherapy azoospermia. Twenty-two of 26 men with mature spermatids found in the prior testis biopsy had successful retrieval of spermatozoa for ICSI, 12 of their partners became pregnant, and are either ongoing or delivered. The study suggests that 4-6 mature spermatids/tubule must be present in the testis biopsy for any spermatozoa to reach the ejaculate. More than half of azoospermic patients with germinal failure have minute foci of spermatogenesis which are insufficient to produce spermatozoa in the ejaculate. Prior diagnostic testicle biopsy analysed quantitatively (for the presence of mature spermatids) can predict subsequent success or failure with TESE-ICSI. Incomplete testicular failure may involve a sparse multi-focal distribution of spermatogenesis throughout the entire testicle, rather than a regional distribution. Therefore, it is possible that massive testicular sampling from many different regions of the testes may not be necessary for successful TESE-ICSI.