研究生人格类型与应付方式间的关系研究

目的探讨研究生人格类型与其应付方式的关系,为研究生的教育、管理提供依据。方法用MBTI人格类型量表和应付方式问卷对南京某综合性大学的468名研究生进行测量。结果在应付方式问卷上,成熟的应付方式得分较高,不成熟和混合型的应付方式得分显著较低（P〈0.001）;某些应付方式存在性别、年级和专业的显著差异（P〈0.05或P〈0.01）。在MBTI人格类型量表上,16种人格类型分布有显著差异,其中,最多的是ESTJ（外倾感觉思维判断）型,占总数的12.4%。部分人格维度和人口学因素可以作为应付方式状况的有效判别变量。结论研究生的人格维度、人格类型与其应付方式存在一定的关联。     

The functional polymorphism in monocyte chemoattractant protein-1 gene increases susceptibility to gastric cancer

Monocyte chemoattractant protein-1 (MCP-1, CCL2) has been suggested to be associated with gastric cancer. We investigated whether the functional single nucleotide polymorphism A-2518G in CCL2 gene influenced susceptibility to gastric cancer. The CCL2 genotypes were determined using polymerase chain reaction-restriction fragment length polymorphism in 1,216 individuals (608 gastric cancer patients and 608 age- and sex-matched controls). The gastric cancer patients showed a significant higher frequency of the variant G allele compared to the controls (P = 0.01). Compared with the wild-type AA carriers, the variant genotypes (GA + GG) of A-2518G polymorphism were associated with a higher risk of gastric cancer (adjusted odds ratio = 1.55, 95% confidence interval = 1.03-2.35). Moreover, the elevated risk of gastric cancer associated with the variant genotypes was especially noteworthy in rural subjects (adjusted odds ratio = 1.92, 95% confidence interval = 1.01-3.65). In addition, stratification of gastric cancer cases according to clinicopathological characters showed that the polymorphism was associated significantly with the depth of tumor infiltration. Our data suggest that the genetic polymorphism CCL2 A-2518G may not only be associated with an increased risk of gastric cancer, but also with advanced stage of gastric cancer in the Chinese population.     

Type 2 diabetes with neuropathy: autoantibody stimulation of autophagy via Fas

We reported previously that sera from patients with type 2 diabetes and neuropathy induce autophagy in human neuroblastoma (SH-SY5Y) cells. Here we report that enriched immunoglobulin fractions from a subpopulation of these patients induce autophagy and colocalization with Fas-activated death domain (FADD), a component of the Fas-activated death domain receptor signaling pathway. These effects were replicated by treatment of SY5Y cells with Fas ligand, tumor necrosis factor alpha and an agonist anti-Fas antibody. Preincubation of these sera with a soluble Fas receptor chimera (extracellular domain) markedly decreased the stimulation of autophagy. The results suggest that sera from subset of individuals with type 2 diabetes and neuropathy contain autoantibodies that activate the Fas cascade.     

药膳食疗在临床营养治疗中的应用

中医学是中华民族文化的一大辉煌成就,是炎黄子孙几千年来不断实践、总结、完善、发展的科学结晶。中医药膳食疗就是这伟大成就中的一部分。随着经济的发展,人民生活水平的提高,工作节奏的加快,药膳食疗的保健治疗作用越来越被人们所重视和接受。     

Intravenous lidocaine simultaneously infused with sufentanil to accelerate gastrointestinal function recovery in patients after thoracolumbar surgery: a prospective,randomized, double-blind controlled study

Purpose

Postoperative gastrointestinal dysfunction is one of the common complications of surgery, especially after surgery for a thoracolumbar spinal fracture. Intravenous lidocaine is a potential method to improve postoperative gastrointestinal function in surgical patients, reduce opioid use and shorten hospital stays. The purpose of this study is to explore the effect of intravenous lidocaine on the recovery of gastrointestinal function in patients after thoracolumbar surgery.

Methods

In this study, 48 eligible patients undergoing elective thoracolumbar spine fractures resection and internal fixation surgery were enrolled to receive intravenous injections of lidocaine in different concentrations during the perioperative period. Patients were randomly divided into three groups: control group (group A), low concentration of lidocaine group (group B) and high concentration of lidocaine group (group C), 16 patients in each group. First postoperative exhaust time, numbers of bowel sound at preoperative and postoperative 3, 6, 12, 24 h, pain scores at postoperative 0, 3, 6, 12, 24, 48 h, total sufentanil use in PACU and perioperative periods, postoperative hospital stay and analgesic remedy within postoperative 48 h were recorded and compared. The primary endpoints include: the time of first flatus passage after the operation, the number of bowel sounds per minute counted with stethoscope at 30 min before anesthesia induction and at 3, 6, 12 and 24 h postoperative. The secondary endpoints included: the pain scores at PACU (after entering into PACU), 3, 6, 12, 24 and 48 h postoperative, the amount of sufentanil administrated by intravenous push during operation and the numbers of patients needed rescuing sufentanil in PACU, and the numbers of patients needed administration of gastric motility drugs or non-steroidal analgesics at ward within 48 h postoperation, length of hospital stay (from the first day after surgery to discharge from hospital) and the incidence of adverse reactions.

Results

Compared with group A, the first postoperative exhaust time in group B and C occurred much earlier (23.3 ± 11.0 h vs. 16.0 ± 6.6 h, 16.6 ± 5.1 h, P < 0.05). Compared with preoperation, the numbers of bowel sound significantly increased at 24 h postoperatively in group B, while group B at 6 h and group C at 6 and 24 h postoperatively had significantly more active bowel sounds compared to group A (P < 0.05). There were no remarkable differences in VAS scores within 12 h postoperatively among three groups, and however, significantly lower VAS scores were found at 12, 24 and 48 h postoperatively in group C when comparing to Group A (p < 0.05). There was no statistical significance in the incidence of postoperative flatulence and nausea and vomiting, the number of patients needed rescuing sufentanil in PACU, the length of postoperative hospital stay and the number of patients requiring non-steroidal analgesics at ward within 48 h postoperation.

Conclusions

Intravenous lidocaine infusion together with patient-controlled analgesia of sufentanil expedited the early recovery of gastrointestinal function and improved analgesic quality of sefentanyl in patients undergoing thoracolumbar surgeries.

     

Ge—132衍生物合成结构及生物活性的研究(Ⅰ)

合成了5种未见报导的Ge—132衍生物—B-酚酯基乙基锗倍半氧化物,根据元素分析、IR光谱和快原子轰击质谱确定了它们的组成和结构。IR 光谱中均出现800～900cm~(-1)的强γGe-O 特征吸收峰,FAB-MS 和IR 光谱均证实系列衍生物存在-Ge-O-Ge-大环网络结构,并断定它们具有同Ge—132相似的空间结构。分析了它们的热分解机理。     

精神分裂症患者服药依从性与家庭环境的相关性研究

目的：分析精神分裂症患者服药依从性与家庭环境的相关性。方法：对495名精神分裂症患者进行问卷调查。调查工具包括一般资料问卷、家庭环境量表中文版（FES-CV）和精神分裂症患者服药依从性问卷。结果：单因素分析结果显示,年龄、病程、住院次数、就诊方便程度、家庭经济状况、医疗费用情况和家人是否参加过健康教育是精神分裂症患者服药依从性的影响因素（P〈0.05）;精神分裂症患者家庭环境量表各维度得分与国内常模相比均有统计学差异（P〈0.05）;精神分裂症患者服药依从性量表各维度得分与家庭环境量表各维度得分相关（P〈0.05）;分层回归分析显示,亲密度、病程、就诊方便程度和住院次数均为精神分裂症患者服药依从性的影响因素。结论：精神分裂症患者服药依从性与其家庭环境密切相关,应加强对患者家庭的护理干预,以提高患者的服药依从性。     

1例脾破裂并发渗出性胸膜炎病人的护理

脾破裂出血术后并发肺炎在临床上较常见,而并发渗出性胸膜炎较为罕见.我科收治1例由于脾破裂出血而致渗出性胸膜炎的病人.现将护理报告如下.     

颈动脉粥样硬化与血脂水平的相关性分析

目的研究颈动脉粥样硬化与血脂水平之间的关系。方法采用彩色多普勒超声对2 892例健康体检人员行双侧颈动脉检查,分析颈动脉粥样硬化与血清总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平的关系。结果颈动脉粥样硬化组血脂水平高于对照组(P0.01);不同年龄段颈动脉粥样硬化组和对照组间血脂水平比较:LDL-C在30~79岁、TC在30~59岁、TG在40~59岁年龄段颈动脉粥样硬化组高于对照组(P0.05);HDL-C在40~49岁年龄段颈动脉粥样硬化组低于对照组(P0.01)。颈动脉粥样硬化组和对照组间不同水平血脂构成比均差异有统计学意义(P0.01)。结论健康体检人员颈动脉粥样硬化与血脂水平有关联,积极降低血脂尤其是LDL-C,是防治动脉粥样硬化相关性疾病的一项重要措施。     

Investigation on Crystallization and Magnetic Properties of (Nd,Pr, Ce)2Fe14B/α-Fe Nanocomposite Magnets by Microwave Annealing Treatment

In the present work, the structures and magnetic properties of (Nd, Pr, Ce) ₂Fe₁₄B/α-Fe nanocomposite magnets were thoroughly investigated. The microwave annealing was applied to achieve a uniform heating effect and uniform grains. Microwave annealing is more favorable to obtain α-Fe phase than conventional annealing, which leads to the enhanced coercivity of hysteresis loops. The coercivity of nanocomposite magnets was 245 kA/m after annealing at 2000 W for 10 min.