微创翼状胬肉切除联合自体角膜缘干细胞移植治疗翼状胬肉

目的探讨微创翼状胬肉切除+自体角膜缘干细胞移植术治疗翼状胬肉的疗效。方法对260例翼状胬肉患者在局麻下行显微镜下微创胬肉切除,将同侧眼颞上方带有角膜缘干细胞的结膜瓣移植到胬肉处的巩膜上。结果术后反应轻,移植片均存活,降低了复发率。结论自体角膜缘干细胞移植治疗翼状胬肉可行性好。     

利妥昔单抗联合糖皮质激素治疗难治性大疱性皮肤病临床分析

目的:观察利妥昔单抗(联合糖皮质激素)治疗难治性大疱性皮肤病的临床疗效及不良反应.方法:14例确诊的难治性大疱性皮肤病(8例寻常型天疱疮、3例大疱性类天疱疮、2例获得性大疱性表皮松解症、1例红斑型天疱疮)患者,按体表面积375 mg/m2静脉滴注利妥昔单抗,每周1次,共4次(第1、8、15、22天).治疗前均做血、尿常规,肝、肾功能,血脂,血糖,电解质,免疫球蛋白,血清疱病特异抗体及外周血流式细胞仪CD3、CD19、CD20细胞计数等检查,并在治疗中以及治疗结束后定期复查.结果:14例患者中11例完全缓解,3例部分缓解.完全缓解的11例患者中,2例已完全停药;其余患者糖皮质激素逐渐减量中.3例部分缓解患者,皆已停用所有药物,皮损仅在外力碰撞后出现.出现2例复发病例;还有1例在治疗后3个月因肺部感染死亡.结论:利妥昔单抗(联合糖皮质激素)治疗难治性大疱性皮肤病有明确的疗效,且不良反应较少.     

建立小型猪Ⅱ度根分叉缺损模型的可行性

背景：牙槽骨缺损再生的前提是建立可有效评价牙周骨组织再生的实验性牙槽骨缺损动物模型,以往研究用于观察牙周组织病变的模型动物多选用狗,但操作难度大。目的：观察利用小型猪建立Ⅱ度根分叉缺损动物模型的可行性。方法：制备小型猪Ⅱ度根分叉缺损模型。将小型猪实验牙随机分为2组,模型组造模后不注射任何药物干预,对照组于造模后注射具有成骨作用的辛伐他汀凝胶。结果与结论：建模8周后大体、病理切片观察结果均显示模型组根分叉区空虚,对照组见新生牙槽骨长入。对照组可见较成熟的纤维组织以及增生的血管、大量成骨细胞、骨细胞,而模型组可见增生血管及少量成骨细胞。结果证实,以小型猪构建Ⅱ度根分叉缺损模型是可行的。     

Paxillin expression levels are correlated with clinical stage and metastasis in salivary adenoid cystic carcinoma

J Oral Pathol Med (2010) 39 : 548–551 Aims: To investigate the relationship between paxillin expression and clinicopathological features and metastasis in salivary adenoid cystic carcinoma (SACC). Methods: A total of 47 SACC were assessed histochemically for paxillin expression. Paxillin immunoreactivity was compared with histological type, clinical stage and distant metastasis. Results: Paxillin expression was identified in 57.45% of SACC as cytoplasmic staining and the expression was correlated with distant metastasis and clinical stage (P < 0.05), but not with histological type. Conclusions: Our observations indicate that paxillin expression is upregulated in SACC. High expression of paxillin was correlated with a more advanced stage and metastasis in SACC, suggesting that paxillin is a disease marker in advanced SACC and SACC with distant metastasis, and, consequently, may have value as a therapeutic target for SACC.     

腹腔镜辅助与开腹子宫肌瘤切除术的临床研究

目的 比较腹腔镜辅助和开腹子宫肌瘤切除术的临床效果.方法 回顾分析2007年1月～2010年1月笔者所在医院经腹腔镜辅助及开腹行子宫肌瘤切除术的患者临床资料.结果 腹腔镜辅助组术后使用止痛剂率、住院时间、肛门排气时间、体温恢复正常时间、生活恢复自理时间均明显短于开腹组,差异有统计学意义（P＜0.01）,两组手术时间、术中出血量、术后2年内复发率大致相同,无显著性差异（P＜0.05）.结论 腹腔镜辅助子宫肌瘤切除术具有创伤小、术后康复快、疼痛轻等优点,安全有效.     

Psychological and behavioural impacts of the 2008 China earthquake on blood donors

Background and Objectives On May 12, 2008, a severe earthquake hit Sichuan province in China. A post‐earthquake survey was conducted to study the earthquake’s effect on blood donor behaviour and stress at three blood centres at varying distances from the epicentre. Materials and Methods A questionnaire was developed to assess donor post‐traumatic stress disorders (PTSD) and attitudes toward giving blood. Responses were compared by centre and donor characteristics using multivariate logistic regression techniques. Results Of all 17 456 donors, the overall prevalence of PTSD was 13·2%. Donors who knew someone killed or injured by the earthquake were 2·1 times more likely to have PTSD than others (95% CI: 1·8–2·4). 85·2% of donors cited the earthquake as their reason for donating. 16·1% of donors felt it acceptable to be less honest about one’s health history in an emergency. After adjusting for PTSD, geographic and demographic characteristics, the donors knowing someone killed or injured by the earthquake were 1·4 times (95% CI: 1·2–1·7) more likely to cite the earthquake as reason for donating, and 1·8 times (95% CI: 1·5–2·1) more likely to accept being less honest about one’s health history in case of national emergency. Conclusions The psychological and behavioural impacts of the earthquake on blood donors extended far from the epicentre. After a disaster, it is important to emphasize that donors must be truthful on the donor questionnaire as some donors appear willing to be less than honest when they perceive an increased need for blood products.     

Dundee Ready Education Environment Measure: psychometric testing with Chinese nursing students

Title. Dundee Ready Education Environment Measure: psychometric testing with Chinese nursing students. Aim. This paper is a report of the psychometric testing of the Dundee Ready Education Environment Measure with Chinese nursing students. Background. Although the Dundee Ready Education Environment Measure has been widely used to measure educational environments in the healthcare professions, no psychometric evaluation of the measure with Chinese nursing students has been reported. Method. Data from 214 nursing students were collected during a 2‐month period between December, 2004 and January, 2005. Exploratory factor analysis, internal consistency reliability and Cronbach’s alpha were examined. Results. Five factors were found by principal components analysis with Oblimin with Kaiser Normalization rotation. The original factor names were maintained, but items in each factor changed. These five factors all achieved eigenvalues >1, and in total accounted for 52·186% of the variance. Cronbach’s alpha ranged from 0·623 to 0·9 across factors, with an overall alpha of 0·949. Conclusion. The Chinese version of the Dundee Ready Education Environment Measure could be a valuable measurement for nursing educators in professional development programmes and nursing curriculum design. Further studies need in different Chinese nursing schools and larger sample sizes to be conducted to validate its stability and factor structure.