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21.
Hepatitis C virus (HCV) leads to chronic infection in the majority of infected patients presumably due to failure or inefficiency of the immune responses generated. Both antibody and cellular immune responses have been suggested to be important in viral clearance. Non-replicative adenoviral vectors expressing antigens of interest are considered as attractive vaccine vectors for a number of pathogens. In this study, we sought to evaluate cellular and humoral immune responses against HCV NS4 protein using recombinant adenovirus as a vaccine vector expressing NS4 antigen. We have also measured the effect of antigen doses and routes of immunization on the quality and extent of the immune responses, especially their role in viral load reduction, in a recombinant Vaccinia-HCV (Vac-HCV) infection mouse model. Our results show that an optimum dose of adenovirus vector (2 × 107 pfu/mouse) administered intramuscularly (i.m.) induces high T cell proliferation, granzyme B-expressing CD8+ T cells, pro-inflammatory cytokines such as IFN-γ, TNF-α, IL-2 and IL-6, and antibody responses that can significantly reduce the Vac-HCV viral load in the ovaries of female C57BL/6 mice. Our results demonstrate that recombinant adenovirus vector can induce both humoral and cellular protective immunity against HCV-NS4 antigen, and that immunity is intricately controlled by route and dose of immunizing vector. 相似文献
22.
Kee Thai Yeo Ju Lee Oei Daniele De Luca Georg M. Schmölzer Robert Guaran Pamela Palasanthiran Kishore Kumar Giuseppe Buonocore Jeanie Cheong Louise S. Owen Satoshi Kusuda Jennifer James Gina Lim Ankur Sharma Sabita Uthaya Christopher Gale Elizabeth Whittaker Cheryl Battersby Neena Modi Mikael Norman Lars Naver Eric Giannoni Yenge Diambomba Prakeshkumar S. Shah Luigi Gagliardi Michael Harrison Shakti Pillay Abdullah Alburaey Yuan Yuan Huayan Zhang 《Acta paediatrica (Oslo, Norway : 1992)》2020,109(11):2192-2207
23.
24.
Richard S.P. Huang Xinyan Li James Haberberger Ethan Sokol Eric Severson Daniel L. Duncan Amanda Hemmerich Claire Edgerly Erik Williams Julia Elvin Jo-Anne Vergilio Jonathan Keith Killian Douglas Lin Matthew Hiemenz Jinpeng Xiao Deborah McEwan Oliver Holmes Natalie Danziger Rachel Erlich Garrett Frampton Michael B. Cohen Kimberly McGregor Prasanth Reddy Dawn Cardeiro Rachel Anhorn Jeffrey Venstrom Brian Alexander Charlotte Brown Lajos Pusztai Jeffrey S. Ross Shakti H. Ramkissoon 《The oncologist》2020,25(11):943-953
25.
K. V. Arunkumar Viveka Vardhan Reddy David P. Tauro 《Journal of maxillofacial and oral surgery》2010,9(2):127-133
Primary aim
Variability is characteristic of different faces and facial types, and normative data based on one population group does not represent all. Hence, this study was undertaken to establish skeletal cephalometric norms for the South Indian (Karnataka) population utilizing the norms laid by Burstones’s analysis for Caucasians. 相似文献26.
Shakti Singh Deora Madan Nanjappa S. V. Kumaraswamy 《Journal of maxillofacial and oral surgery》2010,9(4):385-388
With the increasingly wide spread application of microvascular free tissue transfer technique for oral cavity reconstruction,
the routine need for variety of local and regional flap has decreased. However, a number of such flaps remains quite useful
and should be included in modern armamentarium of reconstructive surgeon. Nasolabial flap is versatile, simple, easy to harvest
local flap that can cover a variety of defect in face. We present the success and utility of bilateral pedicled flap for reconstruction
of mandibular anterior alveolus after the wide excision of squamous cell carcinoma of mandibular anterior alveolus. And the
restoration of esthetics and functional dental health with the artificial prosthesis. Patient had been followed for two years
and six month with no signs of recurrence as yet. 相似文献
27.
Clinical Trial with Praneem Polyherbal Cream in Patients with Abnormal Vaginal Discharge Due to Microbial Infections 总被引:1,自引:0,他引:1
28.
Visual outcome after fireworks injuries 总被引:1,自引:0,他引:1
BACKGROUND: The epidemiology and prognosis of fireworks-related injuries treated at a tertiary eye care center in less developed nations remain unknown. METHODS: We conducted a prospective observational study that enrolled all consecutive eyes with fireworks-related ocular injury visiting our trauma clinic during a 1-year period. Eyes were graded by ocular trauma classification and followed for 6 months at least. Best corrected visual acuity (BCVA) at 6 months was considered the final visual outcome. Data were analyzed. RESULTS: Twenty-five (96%) of a total of 26 patients enrolled during study period were male patients and 13 (50%) were younger than 15 years. The type of fireworks involved was a bottle rocket in 38.5%. Factors significantly associated with better final visual outcome were better BCVA at presentation (p = 0.041), absence of bottle rocket injury (p = 0.028), closed globe injury (p = 0.028), absence of relative afferent pupillary defect (p = 0.019), absence of intraocular foreign body (p = 0.026), and absence of endophthalmitis (p = 0.006). Besides poor visual outcome, bottle rocket injuries were more frequently associated with facial lacerations, intraocular foreign body, and endophthalmitis development. CONCLUSION: Fireworks-related ocular injuries commonly affect young male subjects of northern India. Visual outcome is better in eyes having better initial BCVA or closed globe injury and if relative afferent pupillary defect, bottle rocket injury, intraocular foreign body, and endophthalmitis are absent. 相似文献
29.
Staphylococcus aureus associated peritonitis and catheter exit site infections (ESI) are an important cause of hospitalization and catheter loss in the patients undergoing chronic peritoneal dialysis (PD). We aimed to determine the potential effectiveness of the application of mupirocin cream at the catheter exit site in preventing exit site infection and peritonitis. METHODS: This prospective historically controlled study was done in a total of 86 patients who entered our PD program from April 1999 to January 2001. They were instructed to apply Mupirocin cream 2% to the exit site daily or on alternate days. The patients were not screened to determine whether they were staphylococcus aureus carriers. One hundred and thirteen patients on PD prior to April 1999 acted as historical controls. Both groups were followed prospectively for a period of 22 months. RESULTS: In the study group application of mupirocin lead to a significant reduction in the incidence rate of both exit site infections overall (0.43 vs. 0.09; p<0.0001) and ESI due staphylococcus aureus (0.14 vs. 0.02; p=0.004) amounting to a relative reduction of 79% and 85% respectively. Although the overall incidence of peritonitis did not change (0.28 vs. 0.26; p=0.7) there was a significant reduction in peritonitis caused by staphylococcus aureus (0.07 vs. 0; p=0.01) Although only one catheter required removal in the mupirocin group as against 5 in the control group, this was not statistically significant. CONCLUSIONS: Mupirocin application at the exit site significantly lowers the incidence of ESI and peritonitis caused by staphylococcus aureus without any significant side effects. 相似文献
30.
Epigenetic programming by maternal behavior 总被引:21,自引:0,他引:21
Weaver IC Cervoni N Champagne FA D'Alessio AC Sharma S Seckl JR Dymov S Szyf M Meaney MJ 《Nature neuroscience》2004,7(8):847-854